Influenza Vaccination-associated Acute Thrombocytopenia and Diffuse Alveolar Hemorrhage

Yamamoto, Yuji; Ohara, Yasuhisa; Iwai, Ami; Hara, Reina; Fukushima, Kiyoharu; Oshitani, Yohei; Kagawa, Hiroyuki; Tsujino, Kazuyuki; Yoshimura, K.; Miki, Mari; Miki, Keisuke; Mori, Masahide; Kida, Hiroshi

doi:10.2169/internalmedicine.3991-19

Cited by 5 publications

(3 citation statements)

References 16 publications

(24 reference statements)

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“…However, in all cases, there was a high level of antibodies to platelet factor-4 (PF4)-polyanion complexes, suggesting a vaccinerelated variant of the phenomenon of heparin-induced thrombocytopenia termed vaccineinduced thrombotic thrombocytopenia (VITT) [24]. Indeed, thrombosis and thrombocytopenia has previously been reported following the use of Measles-Mumps-Rubella [25][26][27][28], influenza [29], pneumococcal [30], smallpox [31], and COVID-19 vaccines [24,[32][33][34][35], but it is unclear if these would all fall into the category of VITT. Thrombotic microangiopathies have previously been reported following influenza vaccination and linked to thrombotic thrombocytopenic purpura, but these reports are rare [36].…”

Section: Mechanismsmentioning

confidence: 99%

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

et al. 2022

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Vaccination efforts as a mitigation strategy in the corona virus disease 2019 (COVID-19) pandemic are fully underway. A vital component of understanding the optimal clinical use of these vaccines is a thorough investigation of adverse events following vaccination. To date, some limited reports and reviews have discussed ocular adverse events following COVID-19 vaccination, but a systematic review detailing these reports with manifestations and clinical courses as well as proposed mechanisms has yet to be published. This comprehensive review one-year into vaccination efforts against COVID-19 is meant to furnish sound understanding for ophthalmologists and primary care physicians based on the existing body of clinical data. We discuss manifestations categorized into one of the following: eyelid, orbit, uveitis, retina, vascular, neuro-ophthalmology, ocular motility disorders, and other.

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Section: Mechanismsmentioning

confidence: 99%

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

et al. 2022

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“…Some involve the immune mechanism and result in a fatal outcome from contracting the flu. For example, thrombocytopenia can be induced by flu 60 and flu vaccination 61 . However, we do not know which genes are responsible for thrombocytopenia.…”

Section: Resultsmentioning

confidence: 99%

PHEVIR: an artificial intelligence algorithm that predicts the molecular role of pathogens in complex human diseases

Zhou

Astore

Skolnick

2022

Sci Rep

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Infectious diseases are known to cause a wide variety of post-infection complications. However, it’s been challenging to identify which diseases are most associated with a given pathogen infection. Using the recently developed LeMeDISCO approach that predicts comorbid diseases associated with a given set of putative mode of action (MOA) proteins and pathogen-human protein interactomes, we developed PHEVIR, an algorithm which predicts the corresponding human disease comorbidities of 312 viruses and 57 bacteria. These predictions provide an understanding of the molecular bases of complications and means of identifying appropriate drug targets to treat them. As an illustration of its power, PHEVIR is applied to identify putative driver pathogens and corresponding human MOA proteins for Type 2 diabetes, atherosclerosis, Alzheimer’s disease, and inflammatory bowel disease. Additionally, we explore the origins of the oncogenicity/oncolyticity of certain pathogens and the relationship between heart disease and influenza. The full PHEVIR database is available at https://sites.gatech.edu/cssb/phevir/.

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“…Sudden and severe onset of thrombocytopenia has been occasionally associated with vaccinations [ 2 ], however, mainly in children receiving a measles–mumps–rubella vaccine [ 11 ]. Furthermore, there are also cases reporting severe thrombocytopenia occurring after influenza vaccinations in adults [ 12 , 13 ] and after SARS‐CoV‐2 vaccinations with both the Pfizer and Moderna versions [ 14 , 15 ], although ITP may also be a complication of an infection with COVID-19 itself [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Severe immune thrombocytopenia following diphtheria, tetanus, pertussis and polio vaccination in a 36-year-old Caucasian woman: a case report

et al. 2022

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Background Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by low platelet counts and increased bleeding risk. The disease may be induced by other disorders, including malignancies, autoimmune diseases, infectious agents or drugs. However, ITP has also been described following vaccinations, such as the measles–mumps–rubella vaccination. In rare cases, ITP may occur in children who received a DTaP-IP (diphtheria, tetanus, acellular pertussis vaccine and inactivated poliovirus) vaccine. Hereinafter, we report the first well-documented cases of ITP in an adult patient in the temporal context of a DTaP-IP vaccination. Case presentation This case report attempts to capture the life-threatening picture of a 36-year-old otherwise healthy Caucasian woman with newly diagnosed severe immune thrombocytopenia in the temporal context of a DTaP-IP vaccination. Four days after receiving the vaccine, the women presented to her primary care physician with malaise, fever and recurrent epistaxis. Clinical examination revealed oral petechiae, ecchymoses, and non-palpable petechiae on both legs. The patient was immediately referred to a local hematology unit where she developed hematuria and an intestinal bleeding (WHO Bleeding Grade III) requiring multiple transfusions. After receiving oral corticosteroids and intravenous immunoglobulins, her platelets gradually recovered. Common causes of secondary ITP were ruled out by laboratory investigations, bone marrow and peripheral blood examinations. This raises the possibility of a (secondary) vaccination-associated thrombocytopenia. To the best of our knowledge, this is the first well-documented case of a DTaP-IP vaccination-related ITP in an adult patient in the English literature. Conclusion Although a causal connection between both entities may not be established, we would like to raise awareness in clinicians that ITP following DTaP-IP vaccinations is potentially not limited to children, but may also occur in adults. Users of DTaP-IP booster vaccines should be alert of the possibility of such adverse reactions.

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Influenza Vaccination-associated Acute Thrombocytopenia and Diffuse Alveolar Hemorrhage

Cited by 5 publications

References 16 publications

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

PHEVIR: an artificial intelligence algorithm that predicts the molecular role of pathogens in complex human diseases

Severe immune thrombocytopenia following diphtheria, tetanus, pertussis and polio vaccination in a 36-year-old Caucasian woman: a case report

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