Influenza sequelae: from immune modulation to persistent alveolitis

Cipolla, Ellyse; Huckestein, Brydie R.; Alcorn, John F.

doi:10.1042/cs20200050

Cited by 6 publications

(4 citation statements)

References 140 publications

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“…Chronic, unresolving bronchiolitis and alveolitis can result in progression toward a long-term injury state characterized by degeneration and desquamation of lung epithelium followed by excess epithelial proliferation and mucous cell metaplasia. While these processes are indicative of tissue repair to viral insult, sustained and increased epithelial injury has long-term consequences in the lung ( 27 ). The development of sustained lung repair phenotype was identified by using Masson’s trichrome staining of lung sections and a QuPath, AI-assisted algorithm to classify healthy and repair phenotype tissue (Fig.…”

Section: Resultsmentioning

confidence: 99%

Mitigation of influenza-mediated inflammation by immunomodulatory matrix-bound nanovesicles

Crum,

Huckestien,

Dwyer

et al. 2023

Sci. Adv.

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Cytokine storm describes a life-threatening, systemic inflammatory syndrome characterized by elevated levels of proinflammatory cytokines and immune cell hyperactivation associated with multi-organ dysfunction. Matrix-bound nanovesicles (MBV) are a subclass of extracellular vesicle shown to down-regulate proinflammatory immune responses. The objective of this study was to assess the efficacy of MBV in mediating influenza-induced acute respiratory distress syndrome and cytokine storm in a murine model. Intravenous administration of MBV decreased influenza-mediated total lung inflammatory cell density, proinflammatory macrophage frequencies, and proinflammatory cytokines at 7 and 21 days following viral inoculation. MBV decreased long-lasting alveolitis and the proportion of lung undergoing inflammatory tissue repair at day 21. MBV increased the proportion of activated anti-viral CD4 + and CD8 + T cells at day 7 and memory-like CD62L + CD44 + , CD4 + , and CD8 + T cells at day 21. These results show immunomodulatory properties of MBV that may benefit the treatment of viral-mediated pulmonary inflammation with applicability to other viral diseases such as SARS-CoV-2.

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Section: Resultsmentioning

confidence: 99%

Mitigation of influenza-mediated inflammation by immunomodulatory matrix-bound nanovesicles

Crum,

Huckestien,

Dwyer

et al. 2023

Sci. Adv.

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“…During super-infections, the respiratory immune environment has not yet returned to a steady state, altering the antibacterial immune responses normally generated. Influenza-MRSA and RSV-PA super-infections are among the most common, and numerous reviews outlining super-infection immune responses exist ( 54 , 68 - 71 ). Because super-infections involve both a virus, where IFNλ is beneficial, and a bacterium, where the role of IFNλ is more questionable, these models provide more insight into the temporal and contextual roles of IFNλ than a single infection model.…”

Section: Ifnλ In Super-infectionsmentioning

confidence: 99%

IFNλ: balancing the light and dark side in pulmonary infection

Antos

Alcorn

2023

mBio

Self Cite

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Interferon (IFN) represents a well-known component of antiviral immunity that has been studied extensively for its mechanisms of action and therapeutic potential when antiviral treatment options are limited. Specifically in the respiratory tract, IFNs are induced directly on viral recognition to limit the spread and transmission of the virus. Recent focus has been on the IFNλ family, which has become an exciting focus in recent years for its potent antiviral and anti-inflammatory activities against viruses infecting barrier sites, including the respiratory tract. However, insights into the interplay between IFNλs and other pulmonary infections are more limited and suggest a more complex role, potentially detrimental, than what was seen during viral infections. Here, we review the role of IFNλs in pulmonary infections, including viral, bacterial, fungal, and multi-pathogen super-infections, and how this may impact future work in the field.

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“…Long-flu or influenza sequelae also exist but are less frequent than long COVID [ 15 ]. Long-flu symptoms present similarly to long COVID, including anxiety, fatigue, pain, and breathing problems, among others [ 15 , 16 , 17 ]. In fact, the unveiling of long COVID has come alongside an increased understanding of long-term sequelae of other ARIs.…”

Section: Background and Introductionmentioning

confidence: 99%

The Role and Value of Professional Rapid Testing of Acute Respiratory Infections (ARIs) in Europe: A Special Focus on the Czech Republic, Poland, and Romania

Drevinek,

Flisiak,

Nemes

et al. 2024

Diagnostics

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This review aims to explore the role of professional diagnostic rapid testing of acute respiratory infections (ARIs), especially COVID-19 and influenza, ensuring proper disease management and treatment in Europe, and particularly in Czech Republic, Poland, and Romania. The paper was constructed based on a review of scientific evidence and national and international policies and recommendations, as well as a process of validation by four experts. The development of new testing technologies, treatment options, and increased awareness of the negative multidimensional impact of ARI profiles transformed differential diagnosis into a tangible and desirable reality. This review covers the following topics: (1) the multidimensional impact of ARIs, (2) ARI rapid diagnostic testing platforms and their value, (3) the policy landscape, (4) challenges and barriers to implementation, and (5) a set of recommendations illustrating a path forward. The findings indicate that rapid diagnostic testing, including at the point of care (POC), can have a positive impact on case management, antimicrobial and antibiotic stewardship, epidemiological surveillance, and decision making. Integrating this strategy will require the commitment of governments and the international and academic communities, especially as we identified room for improvement in the access and expansion of POC rapid testing in the focus countries and the inclusion of rapid testing in relevant policies.

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Influenza sequelae: from immune modulation to persistent alveolitis

Cited by 6 publications

References 140 publications

Mitigation of influenza-mediated inflammation by immunomodulatory matrix-bound nanovesicles

Mitigation of influenza-mediated inflammation by immunomodulatory matrix-bound nanovesicles

IFNλ: balancing the light and dark side in pulmonary infection

The Role and Value of Professional Rapid Testing of Acute Respiratory Infections (ARIs) in Europe: A Special Focus on the Czech Republic, Poland, and Romania

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