Influenza seasonality and vaccination timing in tropical and subtropical areas of southern and south-eastern Asia

Saha, Siddhartha Sankar; Chadha, Mandeep S.; Mamun, Abdullah Al; Rahman, Mahmudur; Sturm‐Ramirez, Katharine; Chittaganpitch, Malinee; Pattamadilok, Sirima; Olsen, Sonja J.; Sampurno, Ondri Dwi; Setiawaty, Vivi; Pangesti, Krisna Nur Andriana; Samaan, Gina; Archkhawongs, Sibounhom; Vongphrachanh, Phengta; Phonekeo, Darouny; Corwin, Andrew L.; Touch, Sok; Buchy, Philippe; Chea, Nora; Kitsutani, Paul; Quynh, Lê; Thiem, Vu Dinh; Lin, Raymond Tzer Pin; Low, Constance; Kheong, Chong Chee; Norizah, I; Yusof, Mohd Apandi; Tandoc, Amado; Roque, Vito G.; Mishra, Akhilesh C.; Moen, Ann; Widdowson, Marc‐Alain; Partridge, Jeffrey; Lal, Renu B.

doi:10.2471/blt.13.124412

Cited by 160 publications

(186 citation statements)

References 37 publications

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“…Our study was conducted during February to May, which was late winter to early spring time in Hong Kong, and the prevalence of different infections may have a seasonal variation, for example, influenza. 31,32 Comparison needs to take account of the season during which the study was conducted.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of infections among residents of Residential Care Homes for the Elderly in Hong Kong

Choy

Chen²,

Yau³

et al. 2016

Hong Kong Med J

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Methods:Residential Care Homes for the Elderly in Hong Kong were selected by stratified single-stage cluster random sampling. All residents aged 65 years or above from the recruited homes were surveyed. Infections were identified using standardised definitions. Demographic and health informationincluding medical history, immunisation record, antibiotic use, and activities of daily living (as measured by Barthel Index)-was collected by a survey team to determine any associated factors.Results: Data were collected from 3857 residents in 46 Residential Care Homes for the Elderly from February to May 2014. A total of 105 residents had at least one type of infection based on the survey definition. The overall prevalence of all infections was 2.7% (95% confidence interval, 2.2%-3.4%). The three most common infections were of the respiratory tract (1.3%; 95% confidence interval, 0.9%-1.9%), skin and soft tissue (0.7%; 95% confidence interval, 0.5%-1.0%), and urinary tract (0.5%; 95% confidence interval, 0.3%-0.9%). Total dependence in activities

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Section: Discussionmentioning

confidence: 99%

Prevalence of infections among residents of Residential Care Homes for the Elderly in Hong Kong

Choy

Chen²,

Yau³

et al. 2016

Hong Kong Med J

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“…Serum samples were collected at enrollment from May to September 2010 prior to the presumed peak dengue virus transmission season (termed ''pre-surveillance'') and in January to March 2011 after the end of the peak dengue season (termed ''postsurveillance''). Though influenza activity is detected year round in Thailand, peak influenza activity is seen primarily from June to November (23). Enhanced passive surveillance for acute febrile illness was conducted during the intervening period.…”

Section: Study Subjects and Blood Samplesmentioning

confidence: 99%

Relationship of Preexisting Influenza Hemagglutination Inhibition, Complement-Dependent Lytic, and Antibody-Dependent Cellular Cytotoxicity Antibodies to the Development of Clinical Illness in a Prospective Study of A(H1N1)pdm09 Influenza in Children

Terajima

Thomas

et al. 2014

Viral Immunology

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The hemagglutination inhibition (HAI) antibody titer is considered the primary immune correlate of protection for influenza. However, recent studies have highlighted the limitations on the use of the HAI titer as a correlate in at-risk populations such as children and older adults. In addition to the neutralization of cell-free virus by antibodies to hemagglutinin and interference of virus release from infected cells by antibodies to neuraminidase, influenza virus-specific antibodies specifically can bind to infected cells and lyse virus-infected cells through the activation of complement or natural killer (NK) cells, via antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent lysis (CDL). We evaluated preexisting HAI, CDL, and ADCC antibodies in young children enrolled in a prospective cohort study of dengue during the epidemic with influenza A(H1N1)pdm09 virus to determine associations between preexisting antibodies and the occurrence of clinical or subclinical influenza virus infection. Though both preexisting HAI and CDL antibodies were associated with protection against clinical influenza, our data suggested that CDL was not a better correlate than HAI. We found that ADCC antibodies behaved differently from HAI and CDL antibodies. Unlike HAI and CDL antibodies, preexisting ADCC antibodies did not correlate with protection against clinical influenza. In fact, ADCC antibodies were detected more frequently in the clinical influenza group than the subclinical group. In addition, in contrast to HAI and CDL antibodies, HAI and the ADCC antibodies titers did not correlate. We also found that ADCC, but not CDL or HAI antibodies, positively correlated with the ages of the children.

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“…Namun demikian, penelitian yang dilakukan Siddharta, dkk. 4 pada tahun 2013 dapat memberikan gambaran mengenai influenza di Asia Tenggara, termasuk di Indonesia. Pada penelitian tersebut, kultur virus influenza positif didapatkan pada 8,8%-24,2% sampel.…”

Section: Pendahuluanunclassified

“…Pada penelitian tersebut, kultur virus influenza positif didapatkan pada 8,8%-24,2% sampel. 4 Hasil ini sejalan dengan penelitian yang dilaporkan sebelumnya oleh Kosasih, dkk. 5 yang menyatakan terdapat 20,1% kasus influenza.…”

Section: Pendahuluanunclassified

Hubungan Status Frailty dengan Serokonversi dan Seroproteksi Vaksin Influenza pada Populasi Usia Lanjut

Koesnoe¹,

Habibah²,

Wahyudi³

et al. 2017

JPDI

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ABSTRAKPendahuluan. Infeksi masih merupakan ancaman yang serius bagi dunia kesehatan saat ini, terutama bagi populasi khusus seperti usia lanjut. Usia dinyatakan sebagai salah satu faktor prediktor dalam keberhasilan vaksinasi. Semakin tua usia seseorang, respon imunnya akan semakin buruk. Respon yang berbeda pada usia lanjut ini diperkirakan karena frailty dan kejadian immunosenescense yang mendasarinya. Penelitian ini dilakukan untuk mengetahui hubungan status frailty dengan respon imun pascavaksinasi influenza pada populasi usia lanjut.Metode. Studi kohort retrospektif ini mengambil data dari penelitian induk dengan subjek usia lanjut berusia ≥60 yang tergabung dalam Posyandu Lansia di 4 kelurahan di Kecamatan Pulo Gadung, Jakarta Timur. Status frailty ditentukan berdasarkan kuisoner Frailty Index 40 Items (FI-40). Vaksin Influenza yang dievaluasi adalah vaksin influenza trivalen inaktif. Serokonversi didefinisikan sebagai peningkatan titer inhibisi hemagglutinin sebanyak 4x lipat. Seroproteksi didefinisikan sebagai titer inhibisi hemagglutinin ≥1:40.Hasil. Terdapat 140 subjek penelitian. Tingkat serokonversi vaksin influenza pada kelompok frail, pre-frail dan sehat adalah 37,9%, 39% dan 60%. Tingkat seroproteksi vaksin influenza pada kelompok frail, pre-frail dan sehat adalah 80%, 92,2% dan 94,8% . Risiko relatif (RR) kelompok pre-frail/frail untuk kejadian tidak serokonversi adalah 0,93 (IK 95% 0,72-1,02) dan RR untuk kejadian tidak seroproteksi adalah 1,7 ( IK 95% 0,5-6,2).Simpulan. Tidak ditemukan hubungan antara status frailty dengan serokonversi dan seroproteksi vaksin influenza pada populasi usia lanjut. Frailty, pre-frail, frail, serokonversi, seroproteksi, usia lanjut, vaksin Kata Kunci:

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Influenza seasonality and vaccination timing in tropical and subtropical areas of southern and south-eastern Asia

Cited by 160 publications

References 37 publications

Prevalence of infections among residents of Residential Care Homes for the Elderly in Hong Kong

Prevalence of infections among residents of Residential Care Homes for the Elderly in Hong Kong

Relationship of Preexisting Influenza Hemagglutination Inhibition, Complement-Dependent Lytic, and Antibody-Dependent Cellular Cytotoxicity Antibodies to the Development of Clinical Illness in a Prospective Study of A(H1N1)pdm09 Influenza in Children

Hubungan Status Frailty dengan Serokonversi dan Seroproteksi Vaksin Influenza pada Populasi Usia Lanjut

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