Influenza Season Hospitalization Trends in Israel: A Multi‐Year Comparative Analysis 2005/2006 Through 2012/2013

Glatman‐Freedman, Aharona; Kaufman, Zalman; Stein, Yaniv; Sefty, Hanna; Zadka, Hilla; Gordon, Barak; Meron, Jill; Gordon, Ethel-Sherry; Dichtiar, Rita; Haklai, Ziona; Afek, Arnon; Shohat, Tamy

doi:10.12788/jhm.2824

Cited by 3 publications

(5 citation statements)

References 19 publications

(26 reference statements)

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“…December and February (18). The current study noted an unusual overlapping peak of influenza and RSV virus activity in hospitalized patients as well in non-hospitalized patients in the last four winter seasons (2016-20).…”

Section: Discussionsupporting

confidence: 57%

“…Samples obtained from both hospitalized and non-hospitalized patients in Israel 2009-10, showed that influenza virus A/H1N1pdm09 virus that year was present in the country during the summer season and peaked in July and November 2009 ( Fig 1A). In contrast, in winter seasons of 2013-16, RSV infection was detected in October, when it usually appears and peaked in December and November (18), while influenza infections peaked in February ( Fig 1B) and January ( Fig 1C). Surprisingly, from the winter of 2016-17 onwards, both RSV and influenza co-circulated in October and both peaked around January (Fig 1B and C).…”

Section: Influenza Infection Inhibits Rsvmentioning

confidence: 88%

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Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

Drori

Jacob‐Hirsch

Pando

et al. 2020

Preprint

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Influenza viruses and respiratory syncytial virus (RSV) are respiratory viruses that primarily circulate worldwide during the autumn and winter seasons. Seasonal surveillance shows that RSV infection generally precedes influenza. However, in the last four winter seasons (2016-2020) an overlap of the morbidity peaks of both viruses was observed in Israel, and was paralleled by significantly lower RSV infection rates. To investigate whether the influenza virus inhibits RSV we performed coinfection of Human cervical carcinoma (HEp2) cells or mice with influenza and RSV and we observed that the influenza inhibited RSV growth, both in vitro and in vivo. Mass spectrometry analysis of mouse lungs infected with influenza identified a two-wave pattern of protein expression upregulation, which included members of the interferon-induced protein with tetratricopeptide (IFITs) family. Interestingly, in the second peak of upregulation, influenza viruses were no longer detectable in mouse lungs. We also observed that knockdown and overexpression of IFITs in HEp2 cells affected RSV multiplicity. In conclusion, influenza infection inhibits RSV infectivity via upregulation of IFIT proteins in a two-wave modality. Understanding of the interaction between influenza and RSV viruses and immune system involvement will contribute to the development and optimization of future treatment strategies against these viruses.

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Section: Discussionsupporting

confidence: 57%

Section: Influenza Infection Inhibits Rsvmentioning

confidence: 88%

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

Drori

Jacob‐Hirsch

Pando

et al. 2020

Preprint

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“…7,17 In Israel, occupancy rates of medical beds during the non-influenza season average~90%, and these rates peak at >110%-120% during influenza season. 9 High-occupancy challenges infection control practices, particularly in patients located in hospital hallways, and increases the work load for the staff. Reduced occupancy rates enabled us to implement appropriate infection control practices in a timely manner, as reflected by reduced hospital spread of influenza.…”

Section: Discussionmentioning

confidence: 99%

“…The beginning and the end of the epidemic phase of influenza season, defined as weekly visits due to influenza-like illness rate above 5 cases per 10,000 persons, was determined by the Israeli National Influenza surveillance program. 9…”

Section: Participantsmentioning

confidence: 99%

“…7,8 Currently, Israeli hospitals routinely operate at or near full capacity and have limited ability to rapidly increase services. 9 The management of hospital surge capacity in the epidemic influenza season in southern Israel is a major challenge considering that Soroka University Medical Center (SUMC) is the only tertiary referral center in the region, serving~1 million people, and it is the only hospital in a 60-km radius.…”

mentioning

confidence: 99%

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The impact of incorporating early rapid influenza diagnosis on hospital occupancy and hospital acquired influenza

Nesher

Tsaban

Dreiher

et al. 2019

Infect. Control Hosp. Epidemiol.

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Objective:To assess the impact of incorporating early rapid influenza diagnosis on antimicrobial usage, nosocomial influenza transmission, length of stay, and occupancy rates among hospitalized patients.Setting:A 1,100 bed tertiary-care hospital in southern Israel.Methods:We implemented early rapid detection of influenza with immediate communication of results. Using Orion methods, we compared the 2017–2018 influenza season to the prior season in our hospital and to the 2017–2018 occupancy rates at other Israeli hospitals.Results:During the intervention season, 5,006 patients were admitted; 1,824 were tested for influenza, of whom 437 (23.9%) were positive. In the previous season, 4,825 patients were admitted; 1,225 were tested and 288 (23.5%) were positive. Time from admission to test report decreased from 35.5 to 18.4 hours (P< .001). Early discharge rates significantly increased, from 21.5% to 41.6% at 36 hours, from 37.2% to 54.5% at 48 hours, and from 66% to 73.2% at 72 hours. No increase in repeat ER visits, readmission, or mortality rates was observed. Hospital occupancy decreased by 10% compared to the previous year and was 26% lower than the national rate. Hospital-acquired influenza cases were reduced from 37 (11.4%) to 12 (2.7%) (P< .001). Antibiotic usage was reduced both before and after notification of test results by 16% and 12%, respectively.Conclusions:Implementing this intervention led to earlier discharge of patients, lower occupancy in medical wards, reduced antibiotic administration, and fewer hospital-acquired influenza events. This strategy is useful for optimizing hospital resources, and its implementation should be considered for upcoming influenza seasons.

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The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel

Kassianos,

Cohen,

Civljak

et al. 2024

Expert Review of Respiratory Medicine

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Influenza Season Hospitalization Trends in Israel: A Multi‐Year Comparative Analysis 2005/2006 Through 2012/2013

Abstract: Hospital burden in pediatric and internal medicine departments during influenza seasons in Israel was associated with age and diagnosis. These results are important for optimal preparedness for influenza seasons.

Cited by 3 publications

References 19 publications

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

The impact of incorporating early rapid influenza diagnosis on hospital occupancy and hospital acquired influenza

The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel

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