Influenza-related hospitalizations due to acute lower respiratory tract infections in a tertiary care children’s hospital in Turkey

Böncüoğlu, Elif; Kıymet, Elif; Çağlar, İlknur; Tahta, Neryal; Bayram, Nuri; Ayhan, Fahri Yüce; Genel, Ferah; Ecevıt, Çiğdem; Apa, Hurşit; Çelik, Tanju; Devrim, İlker

doi:10.1016/j.jcv.2020.104355

Cited by 5 publications

(8 citation statements)

References 19 publications

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“…As an example, according to the previous study which was conducted at the same center before the pandemic, 131 patients were hospitalized for influenza-related lower respiratory tract infections between January 2016 and March 2018. 25 This decrease in influenza rate is thought to be related to the infection control measures performed to reduce the spreading of SARS-CoV-2. Data from the countries in Southern Hemisphere indicated also decreased influenza activity mostly due to the widespread mitigation measures.…”

Section: Discussionmentioning

confidence: 99%

“…This result is extremely low that influenza viruses are one of the most detected pathogens in patients with respiratory infections. As an example, according to the previous study which was conducted at the same center before the pandemic, 131 patients were hospitalized for influenza-related lower respiratory tract infections between January 2016 and March 2018 (25). This decrease in influenza rate is thought to be related to the infection control measures performed to reduce the spreading of SARS-CoV-2.…”

Section: Discussionmentioning

confidence: 99%

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Distribution of spreading viruses during COVID-19 pandemic: Effect of mitigation strategies

Kıymet

Böncüoğlu

Şahinkaya

et al. 2021

American Journal of Infection Control

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Background The study aimed to evaluate the distribution of circulating respiratory viral pathogens other than SARS-CoV-2 during the first year of the coronavirus disease–2019 (COVID-19) pandemic with especially focusing on the effects of the national-based mitigation strategies. Methods This single-center study was conducted between March 11, 2020-March 11, 2021. All children who were tested by polymerase chain reaction (PCR) on nasopharyngeal swabs for SARS-CoV-2 and other common respiratory viral pathogens were included in the study. Results A total of 995 children with suspected COVID-19 admitted to the study center. Of these, 513 patients who were tested by PCR for both SARS-CoV-2 and common respiratory viral pathogens were included in the final analysis. Two hundred ninety-five patients were (57.5%) male. The median age was 3 years of age (27 days-17 years). A total of 321 viral pathogens identified in 310 (n:310/513, 60.4%) patients, and 11 of them (n:11/310, 3.5%) had co-detection with more than one virus. The most common detected virus was rhinovirus (n:156/513, 30.4%), and SARS-CoV-2 (n:122/513, 23.8%) followed by RSV (n:18/513, 3.5%). The influenza virus was detected in two patients (0.4%). A total of 193 patients were negative for both SARS-CoV-2 and other pathogens. Conclusion There is a decline in the frequency of all viral pathogens like SARS-CoV-2 in correlation with the national-based mitigation strategies against COVID-19 during the pandemic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Distribution of spreading viruses during COVID-19 pandemic: Effect of mitigation strategies

Kıymet

Böncüoğlu

Şahinkaya

et al. 2021

American Journal of Infection Control

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“…14 Çiftçi et al 8 also pointed out that influenza disproportionately affects the preschool-aged group and causes more frequent hospitalizations. In another study by Böncüoğlu et al, 15 hospitalizations due to influenza-related lower respiratory tract diseases were more common in children under the age of 2 years.…”

Section: Discussionmentioning

confidence: 88%

Evaluation of Influenza Patients Admitted in 2019–2020 Flu Season

Gündüz

Ataş

Ünay

et al. 2022

J Pediatr Infect Dis

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Objective Influenza viruses are among the most common respiratory pathogens for all age groups, and may cause seasonal outbreaks. The aim of our study was to describe the clinical characteristics of influenza cases in the 2019–2020 flu season and to study the risk factors for hospital admission and complications. Methods This was a retrospective study in 251 children (group 1: nonhospitalized; group 2: hospitalized) with influenza in the 2019–2020 flu season. Data on demographic features, influenza type, complaints, complications, and hospitalization length were collected and recorded. Results Influenza A was detected in 199 (79.3%) patients, and influenza B was detected in 52 (20.7%); 43.4% of patients were girls and 56.6% were boys. The mean age of the patients was 3.91 ± 3.3 years (16 days to 18 years). A total of 52 (20.7%) patients were hospitalized. The age of the patients in group 2 was lower than that in group 1 (3.1 vs. 4.2 years, p = 0.03). Group 2 patients were more likely to have creatine kinase (CK) elevation, febrile seizures, and physical examination abnormalities. Group 2 patients were also more likely to have influenza A. Patients with febrile seizures, chronic diseases, abnormal physical examination findings, developed complications, and additional drug use apart from oseltamivir in the treatment were also more likely to require hospitalization. Conclusion Infants and children with chronic diseases, history of febrile seizures, complications, and the use of drugs other than antiviral drugs should be carefully evaluated in case they need hospitalization. Increasing vaccination rates, initiation of antiviral treatment for selected patients, and close monitoring of patients in risk groups can decrease morbidity and mortality. Myalgias are a common complaint in patients with acute influenza infection. Previous studies suggest CK measurement be part of the work-up for the hospitalized patient with acute influenza infection.

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“…Hospitalization due to lower respiratory tract infections was reported to be highest in those younger than 5 years. 6 , 7 , 8 In a recent study, Boncuoglu et al 9 reported that nearly half of the hospitalizations due to influenza infection were in the age group younger than 2 years of age. These studies mainly focused on influenza infections, including the period after the H1N1 2009 pandemic.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the pediatric hospitalizations due to COVID‐19 and H1N1pdm09 virus infections during the pandemic period

Devrim

Böncüoğlu

Kıymet

et al. 2022

Journal of Medical Virology

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There are two major pandemics in the new millennium, including the pandemic of swine influenza and the COVID-19 pandemic. These two pandemics affected children as well as the adult population. In this case-control study, we compared children with COVID-19 infection and those with H1N1pdm09 virus infection. We also compared the demographic factors, underlying disease, and the requirement for intensive care admission between the hospitalized children with COVID-19 infection and children with H1N1pdm09 virus infection who were hospitalized during the 2009 H1N1 pandemic. In this study, we evaluated 103 patients with H1N1pdm09 virus infection and 392 patients with COVID-19 infection. The age was significantly higher in the COVID-19 patients' group compared to the pandemic influenza group (p < 0.001).The ratio of the children ≥12 years was 10.7% (n = 11) in the H1N1pdm09 virus infection and 36.2% (n = 142) in the COVID-19 group. The rate of underlying disease was significantly higher in the patients with H1N1pdm09 virus infections (p = 0.02).The prevalence of underlying disease in patients requiring PICU hospitalization was 69.2% (n = 9/13) compared to 25.7% (n = 124/482) in patients who did not require PICU hospitalization. The rate of underlying disease was significantly higher in the PICU group regardless of COVID-19 or H1N1pdm09 virus (p = 0.002). Our results suggest that older children were more hospitalized for COVID-19 infections compared to pandemic influenza. In addition, regardless of the type of pandemic infection, the underlying disease is an important factor for pediatric intensive care unit admission. This finding is important for developing strategies for the protection of children with the underlying disease in the upcoming pandemics.

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Influenza-related hospitalizations due to acute lower respiratory tract infections in a tertiary care children’s hospital in Turkey

Cited by 5 publications

References 19 publications

Distribution of spreading viruses during COVID-19 pandemic: Effect of mitigation strategies

Distribution of spreading viruses during COVID-19 pandemic: Effect of mitigation strategies

Evaluation of Influenza Patients Admitted in 2019–2020 Flu Season

Comparison of the pediatric hospitalizations due to COVID‐19 and H1N1pdm09 virus infections during the pandemic period

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