Influenza is more severe than our newest enemy (COVID‐19) in hospitalized children: Experience from a tertiary center

Taşar, Selin; Karadağ‐Öncel, Eda; Yilmaz-Ciftdogan, Dilek; Kara‐Aksay, Ahu; Keleş, Yıldız Ekemen; Elvan‐Tuz, Aysegul; Üstündağ, Gülnihan; Şahin, Aslıhan; Kanik, Muhammet Ali; Yılmaz, Nisel

doi:10.1002/jmv.27817

Cited by 5 publications

(6 citation statements)

References 29 publications

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“…13 Similar to our study, studies comparing hemogram parameters of patients with COVID-19-like symptoms and patients with COVID-19 reported lower leukocytes, neutrophils, and eosinophil counts in the COVID-19 group. [7][8][9]17 Although the virus is expected to cause lymphopenia due to damage to T-lymphocytes, there are conflicting results regarding lymphocyte counts in the literature. 8,9,18 Nonetheless, when patients with COVID-19 were compared with patients with COVID-19-like symptoms, it was shown that only lymphopenia could significantly distinguish patients in the two groups.…”

Section: Discussionmentioning

confidence: 99%

“…6 In studies comparing COVID-19 and other viral infections in children, it has been reported that the lymphocyte count is lower in those with influenza infection, and the leukocyte and neutrophil counts are higher in patients with influenza and human adenovirus infections. [7][8][9] In studies comparing viral infections such as influenza and respiratory syncytial virus with COVID-19, the NLR was found to be lower in COVID-19. 8,10 Therefore, complete blood count parameters, which are frequently requested laboratory tests in the emergency department, can be used for diagnosis, especially in cases where serological or molecular tests cannot be performed rapidly in centers with limited resources or when demand exceeds supply due to seasonally increasing respiratory tract infections, and may be necessary for the isolation decision.…”

Section: Introductionmentioning

confidence: 99%

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Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections

Çelik,

Kasap,

Çakan

et al. 2024

JPA

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To fight against the pandemic, which has become the most significant public health problem of modern times, the isolation of patients and early detection of the coronavirus-2019 (COVID-19) disease are crucial. This study aimed to show the diagnostic predictor of hemogram parameters and the rates obtained from these parameters in differentiating COVID-19 from other respiratory tract diseases. Data of patients aged between 1 month and 18 years who were admitted to the 3rd and 2nd level pediatric emergency with the pre-diagnosis of “COVID-19-like disease” between 12 January 2022 and July 12, 2022, which is one month after the Omicron (Nu) variant was accepted as an established variant in Türkiye, were retrospectively reviewed. A total of 724 children with pre-diagnosis of COVID-19-like disease whose complete blood count and Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) polymerase chain reaction (PCR) test from oropharynx/nasopharyngeal swab samples were included in the study. Two hundred children were positive for SARS-CoV-2 PCR (27.6%). Total leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, platelets, platelet distribution width, platelet crit counts, and neutrophil/lymphocyte ratio were lower, and hemoglobin values were higher in the COVID-19 group than in the other group. These differences were statistically significant (p<0.05). When these parameters were evaluated by receiver operating characteristic analysis, the area under the curve values of the other parameters, except the eosinophil count, were statistically significant. However, when the obtained possibility ratios were examined, significant cut-off values could not be obtained regarding diagnostic predictiveness. It was found that using complete blood count parameters in the diagnostic process is not helpful in differentiating SARS-CoV-2 from other respiratory tract diseases. It is essential to conduct studies with larger sample sizes to understand whether complete blood count parameters can predict the diagnosis of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections

Çelik,

Kasap,

Çakan

et al. 2024

JPA

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“…Although it was thought that our newest enemy (COVID-19) would cause more serious consequences than other respiratory tract infections, recent studies have revealed that influenza is not such a benign virus in children [ 25 ]. Tasar et al demonstrated that influenza caused more frequent admissions to intensive care units and a greater need for respiratory support in hospitalized pediatric patients than did COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…This will allow doctors to implement appropriate treatment as soon as possible to make it as effective as possible. Based on the study by Tasar et al, it can be concluded that influenza can be a serious and frequent cause of complications in children [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Influenza and Influenza-Like Virus Infection in Children Under 14 Years of Age: An Investigation of 725 Cases in the 2021/2022 Influenza Epidemic Season in Poland

et al. 2023

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Background:Influenza in children poses a significant health problem worldwide. In this study we investigated 725 cases of influenza and influenza-like virus infection in children under 14 years of age in the 2021/2022 influenza epidemic season in Poland. Material/Methods:The material for the study (nose and throat swabs) was collected during the 2021/2022 epidemic season. We analyzed 725 samples from the National Influenza Center, Department of Influenza Research at the National Institute of Public Health NIH-NRI or at 16 Voivodship Sanitary Epidemiological Stations across Poland. Quantitative polymerase chain reaction (qRT-PCR) was applied to determine the influenza virus type and subtype (in RNA isolated from positive samples). Results:This study shows the high incidence of influenza among children under the age of 14. Most confirmed infections were caused by influenza A. The genetic material of the A/H1N1/pdm09 subtype was not found among the analyzed samples. The highest number of influenza A infections was among the youngest children (the 0-4 years age group). The most common influenza-like virus was respiratory syncytial virus (RSV). The greatest number of cases caused by this respiratory virus was registered among the youngest children (0-4 years). Conclusions:This study, which shows the high incidence of influenza among children under the age of 14, highlights the importance of regular influenza vaccination. Since children often play a dominant role in spreading influenza virus in the community, regular vaccination can have both health and economic benefits for all age groups.

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“…Lymphocyte decrease or lymphopenia in children with influenza A or B and its association with disease severity have been reported. [28][29][30][31][32] Lymphopenia negatively affects the host adaptive immune responses and prolongs the clinical course of viral infection. 31 A recent study showed that CD4 + T cells promoted influenza virus-specific CD8 + T cell memory, and induced the differentiation of CD8 + cells into cytotoxic effector cells, which helped to eliminate virus.…”

mentioning

confidence: 99%

A Comparative Study of Severe and Critical Influenza B in Children in the 2021–2022 Winter Season

Li¹,

Liu²,

Lang³

et al. 2022

IJGM

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Influenza B viruses are less common than influenza A viruses in most seasons and cause relatively milder forms of infection that are less studied. We witnessed a dominance of influenza B in Shijiazhuang, China, in the 2021-2022 winter season. In this study, we comparatively investigated the severe and critical influenza B in pediatric patients. Methods: Children who were hospitalized from December 2021 to January 2022 and diagnosed with influenza B were included in this study. Those who tested positive for COVID-19 were excluded. Demographic data, clinical features, underlying medical conditions, laboratory testing results, and treatment outcomes were retrieved and analyzed retrospectively. Disease severity was classified as severe or critical according to Chinese expert consensus on diagnosis and treatment of influenza in children. Results: A significantly greater proportion of patients with critical influenza had extra-pulmonary complications and bacterial coinfections. Children with critical influenza B had substantially higher levels of procalcitonin and lactate dehydrogenase, a markedly higher neutrophil percentage and a significantly lower CD4+ lymphocyte percentage. Conclusion: Our findings suggest that, to effectively manage critical influenza B, therapeutic regimens should consist of organspecific supportive care, antibiotic application if bacterial coinfection is present, and anti-inflammatory and immune-boosting treatments.

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Influenza is more severe than our newest enemy (COVID‐19) in hospitalized children: Experience from a tertiary center

Cited by 5 publications

References 29 publications

Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections

Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections

Influenza and Influenza-Like Virus Infection in Children Under 14 Years of Age: An Investigation of 725 Cases in the 2021/2022 Influenza Epidemic Season in Poland

A Comparative Study of Severe and Critical Influenza B in Children in the 2021–2022 Winter Season

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