Influenza immunization among Chinese seniors: Urgent calling for improving vaccination coverage, education, and research

Li, Xin; Leng, Sean X.

doi:10.1002/agm2.12103

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…The situation in China is even more concerning as a national survey conducted from 2004 to 2014 reported vaccination coverage in China as low as 1.5 %–2% ( Yang et al, 2016 ). Therefore, efforts for promoting vaccination coverage ( Li and Leng, 2020 ) and evidence supporting such efforts have profound public health implications, particularly in the era of the ongoing COVID-19 pandemic.…”

Section: Discussionmentioning

confidence: 99%

Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality

Cheng

Cao

et al. 2020

Ageing Research Reviews

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Highlights Compared to unvaccinated people, influenza-vaccinated people had the risk reduction of 26% for cardiovascular diseases (63 studies), 18% for respiratory diseases (29 studies), and 43% for all-cause mortality (43 studies). Influenza vaccination was associated with reduced risk of stroke, myocardial infarction, acute coronary syndrome (ACS), heart failure, ischemic heart disease (IHD), major adverse cardiovascular events (MACEs), and cardiovascular mortality. There was a statistically significant reduction in pneumonia and respiratory mortality in those who received the influenza vaccination, with relative risks of 0.79 (95% CI = 0.65-0.95) and 0.79 (95% CI = 0.67-0.92), respectively. The protective effects of vaccination were evident in the general adult population and particularly robust in older adults and in those with pre-existing specific diseases.

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Section: Discussionmentioning

confidence: 99%

Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality

Cheng

Cao

et al. 2020

Ageing Research Reviews

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“…To date, influenza and pneumococcal vaccines remain two of the most potent tools against both types of infections [ 5 , 6 ]. However, the uptake rates of influenza and pneumococcal vaccines among the Chinese elderly have been suboptimal [ 7 , 8 ], which is largely attributable to an absence of national immunization programs for both vaccines [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Elderly Influenza and Pneumococcal Immunization Programs in Beijing, China Using Health Economic Evaluations: A Modeling Study

Aoyagi

Arima

et al. 2023

Vaccines

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(1) Background: Currently, residents ≥ 60 and ≥65 years old in Beijing, China, are eligible for free influenza and pneumococcal polysaccharide vaccines (PPSV23), respectively. The present study aimed to assess the cost-effectiveness of current and alternative strategies of dual influenza and PPSV23 vaccination among the elderly in Beijing. (2) Methods: We developed a Markov state-transition model to compare the costs and the quality-adjusted life years (QALYs) associated with four influenza and PPSV23 vaccination strategies among the elderly in Beijing. The strategies were as follows: (1) no vaccination; (2) only flu vaccine for people ≥ 60 years old; (3) flu vaccine for people ≥ 60 years old and PPSV23 for people ≥ 65 years old; and (4) dual influenza vaccines and PPSV23 for people ≥ 60 years old. Incremental costs and QALYs were quantified to determine the optimal option. If dominant strategies emerged, the Chinese gross domestic product per capita in 2021 (80,976 CNY) was used as the willingness-to-pay (WTP) threshold to covert QALYs into the monetary equivalent. (3) Results: The current program saved costs and increased QALYs compared to no vaccination or flu vaccine-only strategies. However, extending free PPSV23 to people ≥ 60 years old saved 0.35 CNY additionally while increasing QALYs marginally compared with the current policy. Results were robust in all sensitivity analyses. (4) Conclusion: Beijing’s current dual influenza and pneumococcal vaccination program was cost-effective among the elderly compared with the preceding policies of no vaccination and flu-only immunization programs. However, the program can further save money while enhancing the population health by extending PPSV23 to all people ≥ 60 years old.

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“…However, older adults had significantly poorer HAI antibody response to IIV4 than young individuals, implicating age-related immunosenescence as a risk factor. This is in the context of a country with the largest and fastest growing older adult population and yet extremely low influenza vaccination coverage [ 6 ]. Studies like this may serve as a rationale and evidence to support and promote influenza vaccination coverage for older adults in China and other countries/regions with low or no influenza vaccination coverage [ 6 ].…”

mentioning

confidence: 99%

“…This is in the context of a country with the largest and fastest growing older adult population and yet extremely low influenza vaccination coverage [ 6 ]. Studies like this may serve as a rationale and evidence to support and promote influenza vaccination coverage for older adults in China and other countries/regions with low or no influenza vaccination coverage [ 6 ]. It should be noted that vaccination, not vaccine itself, saves lives.…”

mentioning

confidence: 99%

Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective

Leng,

Shaw

2023

Immun Ageing

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Influenza immunization among Chinese seniors: Urgent calling for improving vaccination coverage, education, and research

Cited by 5 publications

References 26 publications

Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality

Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality

Optimization of Elderly Influenza and Pneumococcal Immunization Programs in Beijing, China Using Health Economic Evaluations: A Modeling Study

Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective

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