Influenza (H1N1)–ISCOMs enhance immune responses and protection in aged mice

Sambhara, Suryaprakash; Woods, Samantha; Arpino, Rita; Kurichh, Anjna; Tamane, Alan; Bengtsson, Karen Lovgren; Morein, Brør; Underdown, Brian J.; Klein, Michel; Burt, David S.

doi:10.1016/s0047-6374(97)01889-7

Cited by 12 publications

(2 citation statements)

References 23 publications

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“…vaccination in DBA/2J mice using live influenza viruses which is very easy to perform because it does not require addition of adjuvants. These results, together with results from other groups [26,27] demonstrate that DBA/2J represents a very sensitive yet fully immuno-competent model system which is well suited to investigate adaptive host immune responses to influenza A virus from bird and human origin without the need for prior species-adaptation.…”

Section: Resultssupporting

confidence: 63%

“…Boon et al showed that sera from humans containing cross-reactive antibodies against pandemic H1N1 virus protected DBA/2J mice from an infection with pandemic H1N1 [15]. Sambhara et al immunized DBA/2J mice by subcutaneous injections with immunostimmulatory complexes containing influenza virus antigens and demonstrated that young and aged mice are better protected than control groups which were immunized with a split vaccine that is used in humans [27]. Solórzano et al, infected the lungs of DBA/2J mice with live-attenuated influenza virus and demonstrated that they are protected from lethal infection with pandemic human H1N1 virus [26].…”

Section: Resultsmentioning

confidence: 99%

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Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection

Dengler

May

Wilk

et al. 2012

Virol J

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BackgroundThe mouse represents an important model system to study the host response to influenza A infections and to evaluate new prevention or treatment strategies. We and others reported that the susceptibility to influenza A virus infections strongly varies among different inbred mouse strains. In particular, DBA/2J mice are highly susceptible to several influenza A subtypes, including human isolates and exhibit severe symptoms after infection with clinical isolates.FindingsUpon intra-muscular immunization with live H1N1 influenza A virus (mouse-adapted PR8M, and 2009 pandemic human HA04), DBA/2J mice mounted virus-specific IgG responses and were protected against a subsequent lethal challenge. The immune response and rescue from death after immunization in DBA/2J was similar to those observed for C57BL/6J mice.ConclusionsDBA/2J mice represent a suitable mouse model to evaluate virulence and pathogenicity as well as immunization regimes against existing and newly emerging human influenza strains without the need for prior adaptation of the virus to the mouse.

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Section: Resultssupporting

confidence: 63%