Influenza burden in children newborn to eleven months of age in a pediatric emergency department during the peak of an influenza epidemic

Ploin, Dominique; Liberas, Sylviane; Thouvenot, D.; Fouilhoux, Alain; Gillet, Yves; Denis, Angélique; Chapuis, François; Lina, Bruno; Floret, D.

doi:10.1097/01.inf.0000092191.78339.1a

Cited by 46 publications

(39 citation statements)

References 15 publications

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“…Other studies have detailed a lack of respiratory symptoms among influenza cases, but those findings were primarily among children. In 2002, a study in France found 30% of influenza‐positive inpatient and outpatient children had minimal or no respiratory symptoms 10. Although we did not enroll neonates in our study, Bender et al 11…”

Section: Discussionmentioning

confidence: 85%

“…Such surveillance for respiratory syndromes, including SARI, has been shown to effectively identify influenza cases,9 and several studies have also confirmed influenza infection among hospitalized and non‐hospitalized patients with undifferentiated febrile illness 4, 7. In young children, influenza patients often present for medical treatment with only fever;10 one recent study found that 19% of 106 influenza‐positive hospitalized infants <3 months old had fever but no respiratory symptoms 11…”

Section: Introductionmentioning

confidence: 99%

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Sentinel surveillance for influenza among severe acute respiratory infection and acute febrile illness inpatients at three hospitals in Ghana

Jones

Ampofo

Akuffo³

et al. 2016

Influenza Resp Viruses

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BackgroundInfluenza epidemiology in Africa is generally not well understood. Using syndrome definitions to screen patients for laboratory confirmation of infection is an established means to effectively conduct influenza surveillance.MethodsTo compare influenza‐related epidemiologic data, from October 2010 through March 2013, we enrolled hospitalized severe acute respiratory infection (SARI; fever with respiratory symptoms) and acute febrile illness (AFI; fever without respiratory or other localizing symptoms) patients from three referral hospitals in Ghana. Demographic and epidemiologic data were obtained from enrolled patients after which nasopharyngeal and oropharyngeal swabs were collected, and processed by molecular methods for the presence of influenza viruses.ResultsOf 730 SARI patients, 59 (8%) were influenza positive; of 543 AFI patients, 34 (6%) were positive for influenza. Both SARI and AFI surveillance yielded influenza A(H3N2) (3% versus 1%), A(H1N1)pdm09 (2% versus 1%), and influenza B (3% versus 4%) in similar proportions. Data from both syndromes show year‐round influenza transmission but with increased caseloads associated with the rainy seasons.ConclusionsAs an appreciable percentage of influenza cases (37%) presented without defined respiratory symptoms, and thus met the AFI but not the SARI definition, it is important to consider broader screening criteria (i.e., AFI) to identify all laboratory‐confirmed influenza. The identified influenza transmission seasonality has important implications for the timing of related public health interventions.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Sentinel surveillance for influenza among severe acute respiratory infection and acute febrile illness inpatients at three hospitals in Ghana

Jones

Ampofo

Akuffo³

et al. 2016

Influenza Resp Viruses

View full text Add to dashboard Cite

show abstract

“…Especially in infancy, wheezing frequently is associated with respiratory viral infections and allergy; about 20% of these children have recurrent wheezing episodes and might become asthmatic patients (1)(2)(3). Therefore, influenza virus vaccination is strongly recommended for children under 3 years of age during the peak influenza season (4)(5)(6)(7). However, vaccination rates are low among children with recurrent wheezing, due to frequent hospital visits and hospitalizations.…”

mentioning

confidence: 99%

Immunogenicity and Safety of an Inactivated Trivalent Split Influenza Virus Vaccine in Young Children with Recurrent Wheezing

Bae

Choi

Kwon

et al. 2013

Clin Vaccine Immunol

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e Influenza virus vaccination is recommended for children, but so far, active vaccination has not been achieved because most parents lack knowledge of vaccine safety and many doctors are reluctant to administer vaccine due to concerns that steroids might alter immunogenicity. The aim of this study was to compare the immunogenicity and safety of inactivated trivalent split influenza virus vaccine between children with recurrent wheezing and healthy children of the same age group. Sixty-eight healthy children and 62 children with recurrent wheezing took part in this study. Seroconversion rates, seroprotection rates, geometric mean titers (GMTs), and geometric mean titer ratios (GMTRs) were measured by a hemagglutination inhibition assay for the assessment of immunogenicity. Solicited and unsolicited local and systemic adverse events were measured for the assessment of safety. Regarding immunogenicity, the seroconversion and seroprotection rates showed no difference overall between healthy children and children with recurrent wheezing. Also, no difference was observed between steroid-treated and nontreated groups with recurrent wheezing. Generally, the GMTs after vaccination were higher in the one-dose vaccination groups for healthy children and children with recurrent wheezing, but the GMTRs revealed different results according to strain in the two groups. Regarding safety, solicited local and systemic adverse events showed no differences between healthy children and children with recurrent wheezing. This study demonstrates that inactivated split influenza virus vaccine is able to induce protective immune responses in healthy children, as observed in previous studies, as well as in children with recurrent wheezing who require frequent steroid treatment.

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“…En estudios realizados en EE.UU. y Francia se comunicó que durante la estación gripal, la gripe confirmada por laboratorio era responsable del 28,8% de todas las visitas al servicio de urgencias de niños menores de 5 años, y del 33% de las visitas al servicio de urgencias de niños entre 0 y 11 meses, respectivamente [94,119] .…”

Section: Carga De La Re-emergente Epidemia De La Gripe En Los Niñosunclassified

Nuevas infecciones emergentes: importancia en la salud de los niños

Seventer

DeLoureiro²,

Hamer³

2009

Ann Nestlé [Esp]

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Una interacción compleja entre factores ambientales y humanos, incluyendo factores ecológicos, genéticos, políticos y socioeconómicos, es responsable de la emergencia y la resurgencia de enfermedades infecciosas. Estos factores poseen a menudo un efecto claro sobre los niños y, en consecuencia, las infecciones emergentes pueden ejercer impactos únicos sobre las poblaciones más jóvenes en términos de salud física y mental, así como de bienestar social. Los niños son los miembros más vulnerables de nuestra sociedad. Con el objeto de protegerles mejor frente al impacto de las enfermedades infecciosas emergentes, es imperativo comprender cómo factores que determinan la emergencia de enfermedades y las enfermedades emergentes de por sí pueden afectar al niño. Esto nos permitirá centrarnos en las medidas más apropiadas para no sólo prevenir la infección de poblaciones pediátricas sino también prepararnos para el tratamiento y el cuidado de los niños cuando emerge una enfermedad infecciosa. La gripe es un prototipo de enfermedad infecciosa emergente/resurgente. La gripe epidémica emerge de nuevo cada año en periodos entre las pandemias gripales. Tanto la gripe epidémica como la gripe pandémica pueden ejercer impactos considerables sobre el bienestar de los niños. Durante más de una década hemos previsto la mutación de la gripe aviaria (H5N1) en un virus que puede ser transmitido eficientemente entre humanos. Esto ha dado lugar a esfuerzos considerables para prepararnos frente a una pandemia gripal virulenta. Aunque el potencial pandémico de la gripe aviaria no ha sido tomado (todavía) en consideración, los esfuerzos realizados para prepararnos frente a una pandemia generalizada no han sido en vano. La emergencia imprevista y la rápida propagación de la gripe porcina [gripe A(H1N1)] han dado lugar a una pandemia mundial que ha producido ya efectos considerables sobre niños y adultos. Las escuelas, los hospitales de día, el transporte moderno y los viajes internacionales han facilitado la propagación de esta nueva cepa gripal. La gripe porcina ejemplifica perfectamente cómo interactúan factores ambientales y humanos para dar lugar a la emergencia de una enfermedad infecciosa con impactos únicos sobre los niños.

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Influenza burden in children newborn to eleven months of age in a pediatric emergency department during the peak of an influenza epidemic

Cited by 46 publications

References 15 publications

Sentinel surveillance for influenza among severe acute respiratory infection and acute febrile illness inpatients at three hospitals in Ghana

Sentinel surveillance for influenza among severe acute respiratory infection and acute febrile illness inpatients at three hospitals in Ghana

Immunogenicity and Safety of an Inactivated Trivalent Split Influenza Virus Vaccine in Young Children with Recurrent Wheezing

Nuevas infecciones emergentes: importancia en la salud de los niños

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