Influenza B viruses circulated during last 5 years in Mongolia

Tsedenbal, Naranzul; Tsend-Ayush, Altansukh; Badarch, Darmaa; Jav, Sarantuya; Nymadawa, Pagbajabyn

doi:10.1371/journal.pone.0206987

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…During the study period, different patterns of Victoria and Yamagata-lineage B viruses were observed. Regarding the distribution of the different lineages in relation to the age groups of the population studied, our study showed that both the Victoria and Yamagata viruses were more likely to infect patients aged between five and 14 years, which had also been observed in previous studies [32,33,[40][41][42]. Moreover, it can be observed that Victoria lineage viruses tend to be distributed according to age with a peak in children under 10 years.…”

Section: Discussionsupporting

confidence: 87%

Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019

Rivas

Alegretti²,

Cóppola

et al. 2020

Microorganisms

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Influenza B viruses (IBV) are an important cause of morbidity and mortality during interpandemic periods in the human population. Two phylogenetically distinct IBV lineages, B/Yamagata and B/Victoria, co-circulate worldwide and they present challenges for vaccine strain selection. Until the present study, there was little information regarding the pattern of the circulating strains of IBV in Uruguay. A subset of positive influenza B samples from influenza-like illness (ILI) outpatients and severe acute respiratory illness (SARI) inpatients detected in sentinel hospitals in Uruguay during 2012–2019 were selected. The sequencing of the hemagglutinin (HA) and neuraminidase (NA) genes showed substitutions at the amino acid level. Phylogenetic analysis reveals the co-circulation of both lineages in almost all seasonal epidemics in Uruguay, and allows recognizing a lineage-level vaccine mismatch in approximately one-third of the seasons studied. The epidemiological results show that the proportion of IBV found in ILI was significantly higher than the observed in SARI cases across different groups of age (9.7% ILI, 3.2% SARI) and patients between 5–14 years constituted the majority (33%) of all influenza B infection (p < 0.05). Interestingly, we found that individuals >25 years were particularly vulnerable to Yamagata lineage infections.

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Section: Discussionsupporting

confidence: 87%

Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019

Rivas

Alegretti²,

Cóppola

et al. 2020

Microorganisms

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“…While the exact mechanism for this is not clear, molecular studies suggest that large populations in the tropics can serve as reservoirs of influenza infection throughout the year, with reseeding of drifted viruses possibly leading to outbreaks 29 . However, in the later years, during 2012 to 2013, seasonal Influenza B and H3N2 strains were frequently seen mirroring the global picture 30,31 . In recent years (2014‐2016), there has been a resurgence of A/H1N1 which is reported globally as well 32‐34 .…”

Section: Discussionmentioning

confidence: 99%

“…29 However, in the later years, during 2012 to 2013, seasonal Influenza B and H3N2 strains were frequently seen mirroring the global picture. 30,31 In recent years (2014-2016), there has been a resurgence of A/H1N1 which is reported globally as well. This has been attributed to genetic reassortment of the virus, rapid change in environmental conditions and decrease in host immunity.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Influenza among patients with influenza‐like illness and severe acute respiratory illness in Pakistan: A 10‐year surveillance study 2008‐17

Nisar

Aamir

Badar

et al. 2020

Journal of Medical Virology

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In Pakistan, the burden of influenza was largely unknown, as no formal surveillance system was in place. In 2008, an influenza surveillance system was set up in eight sentinel sites. This study describes the epidemiology of influenza virus using a 10‐year surveillance data from 2008 to 2017. Nasopharyngeal/throat swabs were collected from patients with influenza‐like illness (ILI) and severe acute respiratory illness (SARI) along with relevant epidemiological information. The samples were tested using real‐time reverse transcriptase‐polymerase chain reaction for the detection and characterization of influenza viruses. A total of 17 209 samples were tested for influenza, out of which 3552 (20.6%) were positive; 2151/11 239 (19.1%) were patients with ILI, whereas 1401/5970 (23.5%) were patients with SARI. Influenza A/H1N1pdm09 was the predominant strain with 40.6% (n = 1442) followed by influenza B (936, 26.4%). Influenza A/H1N1pdm09 was predominant among the children (5‐14 years) and adults (15‐64 years). Influenza B strain was predominantly found in the elderly age group (≥ 65 years) accounting for 48% of cases followed by children (2‐4 years) accounting for 37% of cases. This 10‐year surveillance data provides evidence of influenza activity in the country throughout the year with seasonal winter peaks. The results could be used to strengthen the epidemic preparedness and response plan.

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“…For example, 100% of seasonal H3N2 and 99.8% of 2009 pandemic influenza samples was found resistant to adamantanes, M2 inhibitor [ 28 ]. Similarly, due to mutation at particular amino acid, NA inhibitors-resistant human isolates gradually emerged, like H1N1 (NA-I222V/M/L/R/T, H274Y and S334N) [ 29 ], H3N2 (NA-E119V, E11V) [ 30 ], H7N9 (NA-R292K) [ 31 ] and IBV (NA-G104R) [ 32 ]. Given that IBV also has the antigenic drift and can develop drug-resistance, identifying and developing new antiviral drugs is imperative.…”

Section: Discussionmentioning

confidence: 99%

A potential Chinese medicine monomer against influenza A virus and influenza B virus: isoquercitrin

Luo,

Lv,

Wang

et al. 2023

Chin Med

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Background Influenza viruses, especially Influenza A virus and Influenza B virus, are respiratory pathogens and can cause seasonal epidemics and pandemics. Severe influenza viruses infection induces strong host-defense response and excessive inflammatory response, resulting in acute lung damage, multiple organ failure and high mortality. Isoquercitrin is a Chinese medicine monomer, which was reported to have multiple biological activities, including antiviral activity against HSV, IAV, SARS-CoV-2 and so on. Aims of this study were to assess the in vitro anti-IAV and anti-IBV activity, evaluate the in vivo protective efficacy against lethal infection of the influenza virus and searched for the more optimal method of drug administration of isoquercitrin. Methods In vitro infection model (MDCK and A549 cells) and mouse lethal infection model of Influenza A virus and Influenza B virus were used to evaluate the antiviral activity of isoquercitrin. Results Isoquercitrin could significantly suppress the replication in vitro and in vivo and reduced the mortality of mouse lethal infection models. Compared with virus infection group, isoquercitrin mitigated lung and multiple organ damage. Moreover, isoquercitrin blocked hyperproduction of cytokines induced by virus infection via inactivating NF-κB signaling. Among these routes of isoquercitrin administration, intramuscular injection is a better drug delivery method. Conclusion Isoquercitrin is a potential Chinese medicine monomer Against Influenza A Virus and Influenza B Virus infection.

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Influenza B viruses circulated during last 5 years in Mongolia

Cited by 6 publications

References 28 publications

Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019

Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019

Epidemiology of Influenza among patients with influenza‐like illness and severe acute respiratory illness in Pakistan: A 10‐year surveillance study 2008‐17

A potential Chinese medicine monomer against influenza A virus and influenza B virus: isoquercitrin

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