Influenza B Virus Transmission in Recipients of Kidney and Lung Transplants From an Infected Donor

Page, Amelia K. Le; Kainer, Gad; Glanville, Allan R.; Tu, Elise; Bhonagiri, Deepak; Rawlinson, William D.

doi:10.1097/tp.0b013e3181da1933

Cited by 20 publications

(14 citation statements)

References 4 publications

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“…127,128 Direct transmission of influenza through renal and other solid organs has not been directly demonstrated, although renal allografts from acutely infected donors have been associated with delayed graft function. 126 In addition, transmission of influenza can occur if the virus is present in the stem cell products, as has been reported during the 2009 H1N1 pandemic. 129…”

Section: Influenza Epidemiology and Transmissionmentioning

confidence: 98%

“…Transmission of influenza through transplantation of infected allografts has been reported, but such cases appear to be rare and mainly occur with lung transplantation. 125,126 Guidelines from transplantation societies issued during the 2009 pandemic recommended that lungs should not be recovered for transplantation from donors with any influenza infection, and that small intestine should additionally not be recovered from donors with H1N1 pandemic influenza. Other organs can be considered for transplantation treatment with appropriate antiviral therapy.…”

Section: Influenza Epidemiology and Transmissionmentioning

confidence: 99%

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Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients

Weigt

Gregson

Deng

et al. 2011

Semin Respir Crit Care Med

100

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Respiratory viral infections (RVIs) are common causes of mild illness in immunocompetent children and adults with rare occurrences of significant morbidity or mortality. Complications are more common in the very young, very old, and those with underlying lung diseases. However, RVIs are increasingly recognized as a cause of morbidity and mortality in recipients of hematopoietic stem cell transplants (HSCT) and solid organ transplants (SOTs). Diagnostic techniques for respiratory syncytial virus (RSV), parainfluenza, influenza, and adenovirus have been clinically available for decades, and these infections are known to cause serious disease in transplant recipients. Modern molecular technology has now made it possible to detect other RVIs including human metapneumovirus, coronavirus, and bocavirus, and the role of these viruses in causing serious disease in transplant recipients is still being worked out. This article reviews the current information regarding epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment of these infections, as well as the aspects of clinical significance of RVIs unique to HSCT or SOT.

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Section: Influenza Epidemiology and Transmissionmentioning

confidence: 98%

Section: Influenza Epidemiology and Transmissionmentioning

confidence: 99%

Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients

Weigt

Gregson

Deng

et al. 2011

Semin Respir Crit Care Med

100

View full text Add to dashboard Cite

show abstract

“…6 Although severe infection in a kidney recipient from an influenza-positive donor has been reported, such reports are rare. 7 A recent survey of the American Society of Transplantation Infectious Disease Community of Practice demonstrated that more than 90% of practitioners would recommend accepting non-lung organs from influenza-positive donors. 8 Multiple adult centers have reported positive outcomes with transplants from influenza-positive donors, but uncertainty remains regarding the duration of donor and recipient antiviral therapy necessary to prevent disease transmission.…”

Section: Donor Infectious Disease Impacts Organ Acceptance Practicesmentioning

confidence: 99%

Pediatric heart transplant from an incompletely treated influenza A‐positive donor

Smith

McCulloch²,

Shirley

et al. 2019

Pediatric Transplantation

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There is a shortage of pediatric donor hearts for waitlisted children, and yet nearly 50% of organs offered are not transplanted. Donor quality is often cited as a reason for declining organs offered from donors infected with influenza, presumably due to concern about disease transmission at transplant leading to severe disease. We previously described an excellent outcome after heart transplant from a donor infected with influenza B that had been treated with a complete course of oseltamivir. In this report, we describe a similar outcome after transplantation of an organ from an influenza A‐positive donor with symptomatic disease incompletely treated with oseltamivir. Due to the availability of effective antiviral treatment, we suggest that influenza A is also a manageable donor infection that need not preclude heart placement.

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“…DTI of respiratory viruses is further complicated by limited treatment options. Influenza and adenovirus have both been reported as DTI with devastating consequences [115][116][117] . As such, high index of suspicion is needed when evaluating a donor, especially during the peak seasons of respiratory viral infections within the community.…”

Section: Viral Infectionsmentioning

confidence: 99%

Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections

Kovacs¹,

Koval²,

Duin³

et al. 2014

WJT

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Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompting increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor.

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Influenza B Virus Transmission in Recipients of Kidney and Lung Transplants From an Infected Donor

Cited by 20 publications

References 4 publications

Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients

Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients

Pediatric heart transplant from an incompletely treated influenza A‐positive donor

Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections

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