Influenza-Associated Deaths among Children in the United States, 2003–2004

Bhat, Niranjan; Wright, Jean Ann; Broder, Karen R.; Murray, Erin; Greenberg, Michael; Glover, Maleeka; Likos, Anna; Posey, Drew L.; Klimov, Alexander; Lindstrom, Stephen; Balish, Amanda; Medina, Marie Jo; Wallis, Teresa; Guarner, Jeannette; Paddock, Christopher D.; Shieh, Wun Ju; Zaki, Sherif R.; Sejvar, James J.; Shay, David K.; Harper, Scott; Cox, Nancy J.; Fukuda, Keiji; Uyeki, Timothy M.

doi:10.1056/nejmoa051721

Cited by 589 publications

(432 citation statements)

References 21 publications

Supporting

Mentioning

393

Contrasting

Unclassified

Order By: Relevance

“…S. aureus was identified in 69% of these children, the majority (85%) of whom had specimens yielding S. aureus obtained within three days of inpatient admission, indicating that they may have been admitted with a bacterial co‐infection or complication of influenza. As reported previously, young age and high‐risk medical conditions were common among influenza‐associated pediatric deaths 12 , 15 . Healthcare providers should suspect influenza S. aureus co‐infection among children with severe respiratory illness and a suspected or confirmed influenza infection, and treat with appropriate antimicrobial and antiviral agents.…”

Section: Discussionmentioning

confidence: 60%

Influenza-associated mortality among children - United States: 2007-2008

Peebles

Dhara

Brammer

et al. 2010

Influenza and Other Respiratory Viruses

View full text Add to dashboard Cite

Please cite this paper as: Peebles et al. (2010) Influenza‐associated mortality among children – United States: 2007–2008. Influenza and Other Respiratory Viruses 5(1), 25–31. Background Since October 2004, pediatric influenza‐associated deaths have been a nationally notifiable condition. To further investigate the bacterial organisms that may have contributed to death, we systematically collected information about bacterial cultures collected at non‐sterile sites and about the timing of Staphylococcus aureus specimen collection relative to hospital admission. Methods We performed a retrospective, descriptive study of all reported influenza‐associated pediatric deaths in 2007–2008 influenza season in the United States. Results During the 2007–2008 influenza season, 88 influenza‐associated pediatric deaths were reported. The median age was 5 (range 29 days – 17 years); 48% were <5 years of age. The median time from symptom onset to death was 4 days (range 0–64 days). S. aureus was identified at a sterile site or at a non‐sterile site in 20 (35%) of the 57 children with specimens collected from these sites; in 17 (85%) of these children, specimens yielding S. aureus were obtained within three days of inpatient admission. These 17 children were older (10 versus 4 years, median; P < 0·05) and less likely to have a high‐risk medical condition (P < 0·05) than children with cultures from the designated sites that did not grow S. aureus. Conclusions S. aureus continues to be the most common bacteria isolated from children with influenza‐associated mortality. S. aureus isolates were associated with older age and lack of high‐risk medical conditions. Healthcare providers should consider influenza co‐infections with S. aureus when empirically treating children with influenza and severe respiratory illness.

show abstract

Section: Discussionmentioning

confidence: 60%

Influenza-associated mortality among children - United States: 2007-2008

Peebles

Dhara

Brammer

et al. 2010

Influenza and Other Respiratory Viruses

View full text Add to dashboard Cite

show abstract

“…In 2003 and 2004, 45 children older than 6 months with neurologic or neuromuscular disorders died of influenza infection in the US. 1 In spinal muscular atrophy type I respiratory complications 2,3 lead to death during the first year of life, if patients were not invasively ventilated via either tracheotomy or recurrent intubation. Incidences of pneumonia of 0.8/year for Duchenne muscular dystrophy (DMD) and of 1/year for other myopathies are reported.…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive ventilation reduces respiratory tract infections in children with neuromuscular disorders

Dohna-Schwake¹,

Podlewski²,

Voït³

et al. 2007

Pediatric Pulmonology

View full text Add to dashboard Cite

Summary. Non-invasive ventilation (NIV) has been shown to improve gas exchange and survival in patients with chronic neuromuscular disorders. Little is known about its influence on respiratory tract infections (RTIs). Twenty-four patients with regular use of NIVand 11 patients without NIV with neuromuscular disorders answered a questionnaire concerning the use of NIV and assisted coughing techniques, the status of influenza and pneumococcus vaccination, and the frequency and severity of RTIs. Additionally, we performed a retrospective chart review of twelve patients who were ventilated over a period of at least 5 years. In the first year of NIV consultations of a general practitioner due to RTI decreased from 9.2 AE 20.8 to 3.2 AE 5.3 per year (P < 0.005), the number of antibiotic treatment due to RTI decreased from 4.1 AE 3.4 to 1.9 AE 2.2 per year (P < 0.005) and the number of hospital admissions due to RTI decreased from 1.6 AE 1.7 to 0.7 AE 1.3 per year (P < 0.005). Vaccinations against influenza and/or pneumococcus did not have a significant influence on the rate of infections. In 12 patients using NIV for more than 5 years the incidence of RTI requiring hospital admission decreased from 0.54 AE 0.41/year in the pre-ventilation period to 0.12 AE 0.09/year in the NIV period (P < 0.005). NIV had a favorable impact on respiratory infectious complications in children with neuromuscular disorders.

show abstract

“…Since January 1, 2009, the CFR in Egypt has been 11%. The recent increases in infections among children coupled with a decrease in the CFR in the most recent 12-month period suggests that the strain of influenza A virus (H5N1) now circulating in Egypt may be becoming less virulent as it continues to spread among young children, a segment of the population that is highly vulnerable to influenza infections ( 4 , 5 ). …”

mentioning

confidence: 99%

Age-based Human Influenza A Virus (H5N1) Infection Patterns, Egypt

Schroedl¹

2010

Emerg. Infect. Dis.

View full text Add to dashboard Cite

Influenza-Associated Deaths among Children in the United States, 2003–2004

Cited by 589 publications

References 21 publications

Influenza-associated mortality among children - United States: 2007-2008

Influenza-associated mortality among children - United States: 2007-2008

Non‐invasive ventilation reduces respiratory tract infections in children with neuromuscular disorders

Age-based Human Influenza A Virus (H5N1) Infection Patterns, Egypt

Contact Info

Product

Resources

About