Influenza A virus vaccines for swine

Vincent, Amy L.; Pérez, Daniel R.; Rajão, Daniela S.; Anderson, Tavis K.; Abente, Eugenio J.; Walia, Rasna R.; Lewis, Nicola S.

doi:10.1016/j.vetmic.2016.11.026

Cited by 96 publications

(96 citation statements)

References 67 publications

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“…The current standard of vaccination is using whole killed virus vaccines (KV), whereby KVs are most effective if the included strains closely match the currently circulating strains in pigs. KVs are used primarily in breeding females to confer passive immunity to their offspring, which does not protect piglets against infection and transmission of IAV‐S but rather against clinical disease) . Recently, a live attenuated influenza virus vaccine (LAIV) has been reported to be efficacious in heterologous challenges in young piglets .…”

Section: Introductionmentioning

confidence: 99%

Live attenuated influenza virus vaccine reduces virus shedding of newborn piglets in the presence of maternal antibody

Genzow

Goodell

Kaiser

et al. 2018

Influenza Resp Viruses

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BackgroundInfluenza A virus in swine (IAV‐S) causes an acute respiratory disease of swine which results in great economic losses in pig production. Major control strategies include the use of killed vaccines (KV) in breeding females to confer passive immunity to their offspring. A bivalent H1N1 and H3N2 NS1‐truncated live attenuated IAV‐S vaccine have recently become available, which showed promising results in young pigs.ObjectiveThe aim of this study was to investigate the effect of an intranasal vaccination of newborn pigs with or without maternally derived antibodies (MDA) on virus shedding (via nasal swabs tested by virus isolation).MethodsThe study was performed as intratracheal challenge experiments with either a heterologous H1N2 or H3N2 viruses.Results and conclusionThe results of this study showed a significant decrease in the incidence and duration of shedding viable virus for vaccinated newborn piglets with or without MDA, providing strong evidence that intranasal vaccination is overcoming passively acquired maternal immunity. This study indicates that intranasal vaccination with a truncated NS1 live attenuated IAV‐S vaccine of newborn piglets with maternal antibodies can be a valuable tool for reducing the prevalence of heterologous H1N2 and H3N2 IAV‐S in pig herds.

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Section: Introductionmentioning

confidence: 99%

Live attenuated influenza virus vaccine reduces virus shedding of newborn piglets in the presence of maternal antibody

Genzow

Goodell

Kaiser

et al. 2018

Influenza Resp Viruses

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“…Furthermore, mixing of different vaccines from different sources is common in the field and if two LAIV vaccines were to be mixed prior to administration to pigs, there is a chance that a wild type SI will be generated with gene segments derived from unmodified gene segments in each LAIV vaccine. This might lead to even more diversity of swine IAV strains or strains with increased zoonotic potential [6]. …”

Section: Safety and Danger Of Re-assortment Of Laivmentioning

confidence: 99%

“…SI contributes to sub-optimal reproductive performance and is occasionally associated with fever-induced abortion in sows. Immunisation may be a cost effective control measure to combat SI, but the rapid evolution of the virus is a major obstacle SI diversity is reviewed in [1,6,7]. Not all countries with SI use vaccines to control disease.…”

Section: Introductionmentioning

confidence: 99%

“…For autogenous vaccines the vaccine organism(s) must come from the herd in which the vaccine is to be used, and they accounted for more than half of all SI vaccine doses released for sale in 2008. Recent reviews by Sandbulte et al [8] and Vincent et al [6] provide comprehensive information on currently used vaccines in the field in the US. In Europe, RESPIPORC FLU 3 (IDT Biologika, Dessau-Rasslau, Germany) and Gripovac (Merial, Lyon, France) against H1N1, H1N2, and H3N2 circulating SI viruses are used in approximately 5–25% of the pig farms in Belgium, Denmark, France, Spain, Italy, Poland, and Germany.…”

Section: Introductionmentioning

confidence: 99%

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Harnessing Local Immunity for an Effective Universal Swine Influenza Vaccine

Tchilian

Holzer

2017

Viruses

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Influenza A virus infections are a global health threat to humans and are endemic in pigs, contributing to decreased weight gain and suboptimal reproductive performance. Pigs are also a source of new viruses of mixed swine, avian, and human origin, potentially capable of initiating human pandemics. Current inactivated vaccines induce neutralising antibody against the immunising strain but rapid escape occurs through antigenic drift of the surface glycoproteins. However, it is known that prior infection provides a degree of cross-protective immunity mediated by cellular immune mechanisms directed at the more conserved internal viral proteins. Here we review new data that emphasises the importance of local immunity in cross-protection and the role of the recently defined tissue-resident memory T cells, as well as locally-produced, and sometimes cross-reactive, antibody. Optimal induction of local immunity may require aerosol delivery of live vaccines, but it remains unclear how long protective local immunity persists. Nevertheless, a universal vaccine might be extremely useful for disease prevention in the face of a pandemic. As a natural host for influenza A viruses, pigs are both a target for a universal vaccine and an excellent model for developing human influenza vaccines.

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“…The pathogen is an important component of the porcine respiratory disease complex and by itself can have a significant economic impact in the swine industry (Vincent et al, 2008). Swine influenza is ranked among the top three major health challenges in the global swine industry (Vincent et al, 2017). An additional concern regarding SIV, is its zoonotic potential, as under certain circumstances, it can be transmitted to humans, which is best exemplified by 2009 H1N1 pandemic originated from swine source (Maines et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Detailed mapping of the linear B Cell epitopes of the hemagglutinin (HA) protein of swine influenza virus

Zhao¹,

Huang²,

Thomas³

et al. 2018

Virology

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Using the Hemagglutinin (HA) protein peptide array of H1N1 pdm09 and a panel of swine antisera against various swine influenza H1 and H3 clusters, we identified three immunoreactive epitopes with one (peptide 15) located in HA1 (amino acids 57-71) and two (peptides 121 and 139) in HA2 (amino acids 481-495 and 553-566). Further analysis showed that all swine antisera of H1 clusters efficiently recognized two HA2 epitopes; peptides 121 and 139, with only a subset of antisera reactive to HA1-derived peptide 15. Interestingly, none of these peptides were reactive to SIV H3 antisera. Finally, intranasal inoculation of peptides 15 and 121 into pigs revealed that peptide 121, not peptide 15, was able to generate antibody responses in some animals. The results of our experiments provide an important foundation for further analyzing the immune response against these peptides during natural viral infection and also provide peptide substrates for diagnostic assays.

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Influenza A virus vaccines for swine

Cited by 96 publications

References 67 publications

Live attenuated influenza virus vaccine reduces virus shedding of newborn piglets in the presence of maternal antibody

Live attenuated influenza virus vaccine reduces virus shedding of newborn piglets in the presence of maternal antibody

Harnessing Local Immunity for an Effective Universal Swine Influenza Vaccine

Detailed mapping of the linear B Cell epitopes of the hemagglutinin (HA) protein of swine influenza virus

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