Influenza A virus receptors in the respiratory and intestinal tracts of pigeons

Liu, Yuehuan; Han, Caixia; Wang, Xiuqing; Lin, Jian; Ma, Mai‐Juan; Shu, Yuelong; Zhou, Jiao; Yang, Hanchun; Liang, Qian; Guo, Can; Zhu, Jing; Wei, Haitao; Zhao, Jianmin; Ma, Zhijun; Pan, Jie

doi:10.1080/03079450903055363

Cited by 38 publications

(37 citation statements)

References 19 publications

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“…However, exogenous Neu5Gc from Neu5Gc-rich dietary sources (particularly red meat and milk) is able to be metabolically incorporated into human tissue cells (14,15). In nonhuman animals, Neu5Gc has been detected in swine tracheal epithelia (5), on crypt epithelial cells of the duck colon (9) and equine tracheal epithelia (2), and in the trachea and intestine of pigeons (16). In chickens, Neu5Gc has been detected in the trachea and intestine by high-performance liquid chromatography (HPLC) analysis (16) but not in the tracheal epithelia by histological immunostaining (2).…”

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“…In nonhuman animals, Neu5Gc has been detected in swine tracheal epithelia (5), on crypt epithelial cells of the duck colon (9) and equine tracheal epithelia (2), and in the trachea and intestine of pigeons (16). In chickens, Neu5Gc has been detected in the trachea and intestine by high-performance liquid chromatography (HPLC) analysis (16) but not in the tracheal epithelia by histological immunostaining (2). The ratios of Neu5Ac and Neu5Gc have been reported to be 47:53 (mol/mol) in swine tracheal epithelia (5), with more than 90% of Neu5Gc in equine tracheal epithelia (2), 1.8:98.2 (mol/mol) in chicken trachea, and 1.8 to 13.8 Neu5Ac to 86.2 to 98.2 Neu5Gc (mol/mol) in chicken intestines (16).…”

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confidence: 99%

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N -Glycolylneuraminic Acid on Human Epithelial Cells Prevents Entry of Influenza A Viruses That Possess N -Glycolylneuraminic Acid Binding Ability

Takahashi

Takano

Kurebayashi

et al. 2014

J Virol

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Some animal influenza A viruses (IAVs) bind not only to N-acetylneuraminic acid (Neu5Ac) but also to N-glycolylneuraminic acid (Neu5Gc), which has been discussed as a virus receptor. Human cells cannot synthesize Neu5Gc due to dysfunction of the CMP-Neu5Ac hydroxylase (CMAH) gene, which converts CMP-Neu5Ac to CMP-Neu5Gc. However, exogenous Neu5Gc from Neu5Gc-rich dietary sources is able to be metabolically incorporated into surfaces of tissue cells and may be related to enhancement of the infectivity and severity of IAV. Here, we investigated the receptor function of Neu5Gc on IAV infection in

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confidence: 99%

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confidence: 99%

N -Glycolylneuraminic Acid on Human Epithelial Cells Prevents Entry of Influenza A Viruses That Possess N -Glycolylneuraminic Acid Binding Ability

Takahashi

Takano

Kurebayashi

et al. 2014

J Virol

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“…Smietanka et al [21] mentioned that there were no age-related differences in susceptibility between 4-week-old and 1-year-old pigeons after experimental infection. Liu et al [17] reported that virus receptor distribution in pigeons may explain their limited susceptibility to the H5N1 HPAI virus.…”

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confidence: 99%

Limited Susceptibility of Pigeons Experimentally Inoculated with H5N1 Highly Pathogenic Avian Influenza Viruses

Yamamoto

Nakamura

Yamada

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. An experimental infection study was performed using pigeons reared for racing or meat production in Japan and clade 2.2 and 2.3.2 isolates of H5N1 highly pathogenic avian influenza virus to evaluate the possible role of pigeons in virus transmission to poultry. In experiment 1, when 20 pigeons were intranasally inoculated with high or low viral doses, no inoculated pigeon exhibited clinical signs for 14 days. Drinking water and almost all swab samples were negative for virus isolation. Virus isolation was positive in 3 oral swab samples from 2 pigeons from day 2 through 4 postinoculation, but viral titers of positive samples were extremely low. Immunohistochemical analysis for virus detection was negative in all tissue samples. Along with seroconversion in a limited number of pigeons postinoculation, these results suggest that pigeons have limited susceptibility to the virus used for experimental infection. In experiment 2, when uninoculated chickens were housed with virus-inoculated pigeons, all pigeons and contact chickens survived for 14 days without exhibiting any clinical signs. According to serological analysis, the chickens did not exhibit seroconversion after close contact with inoculated pigeons. Our data suggest that the risk posed by pigeons with respect to the transmission of the H5N1 highly pathogenic avian influenza virus to poultry would be less than that for other susceptible avian species.KEY WORDS: H5N1 subtype, highly pathogenic avian influenza, pigeons.

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“…We fortuitously found that the pigeon egg white glycoproteins contain Neu5Acα(2-6)Gal linkage rather than Neu5Acα(2-3)Gal commonly found in other avian species (8). A subsequent report (9) showed that pigeons indeed are more resistant to avian flu.…”

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confidence: 86%