Influenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner
Ashley M. Otero,
Meghan G. Connolly,
Rafael J. Gonzalez-Ricon
et al.
Abstract:Epidemiological studies link neurodevelopmental disorders (NDDs) with exposure to maternal viral infection in utero. It is hypothesized that the mechanism governing this link involves the activation of maternal intestinal T helper 17 (TH17) cells, which produce effector cytokine interleukin (IL)-17. While IL-17 is implicated as a major driver of fetal brain abnormalities, this inflammation-induced TH17 pathway has not been thoroughly examined in models of live viral infection during pregnancy. Influenza A viru… Show more
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