Influenza A(H5N8) virus isolation in Russia, 2014

Marchenko, Vasiliy Y.; Susloparov, Ivan M.; Kolosova, Natalia; Гончарова, Н. И.; Shipovalov, Andrey V.; Durymanov, A. G.; Ilyicheva, T. N.; Budatsirenova, Lubov V.; Ivanova, Valentina K.; Ignatyev, Georgy A.; Ершова, С. Н.; Tulyahova, Valeriya S.; Михеев, В. Н.; Ryzhikov, Alexander B.

doi:10.1007/s00705-015-2570-4

Cited by 44 publications

(32 citation statements)

References 11 publications

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“…It is likely that various poultry production systems and/or practices facilitate the perpetuation of HP IAVs, which can then spill over into wild birds and other host species (29). This observation is consistent with the apparent disappearance in Western Europe of HP H5N1 following detection in 2005, 2006 (30), and 2007 (31) and of H5N8 in 2014 (32). Although not completely resolved, it is very possible that these HP H5 clade 2.3.4.4 viruses were eradicated in North America through the use of quarantine and stamping out policies for poultry by US and Canadian animal health authorities without the use of vaccination.…”

Section: Discussionsupporting

confidence: 71%

The enigma of the apparent disappearance of Eurasian highly pathogenic H5 clade 2.3.4.4 influenza A viruses in North American waterfowl

Krauss

Stallknecht

Slemons

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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One of the major unresolved questions in influenza A virus (IAV) ecology is exemplified by the apparent disappearance of highly pathogenic (HP) H5N1, H5N2, and H5N8 (H5Nx) viruses containing the Eurasian hemagglutinin 2.3.4.4 clade from wild bird populations in North America. The introduction of Eurasian lineage HP H5 clade 2.3.4.4 H5N8 IAV and subsequent reassortment with low-pathogenic H?N2 and H?N1 North American wild bird-origin IAVs in late 2014 resulted in widespread HP H5Nx IAV infections and outbreaks in poultry and wild birds across two-thirds of North America starting in November 2014 and continuing through June 2015. Although the stamping out strategies adopted by the poultry industry and animal health authorities in Canada and the United States—which included culling, quarantining, increased biosecurity, and abstention from vaccine use—were successful in eradicating the HP H5Nx viruses from poultry, these activities do not explain the apparent disappearance of these viruses from migratory waterfowl. Here we examine current and historical aquatic bird IAV surveillance and outbreaks of HP H5Nx in poultry in the United States and Canada, providing additional evidence of unresolved mechanisms that restrict the emergence and perpetuation of HP avian influenza viruses in these natural reservoirs.

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Section: Discussionsupporting

confidence: 71%

The enigma of the apparent disappearance of Eurasian highly pathogenic H5 clade 2.3.4.4 influenza A viruses in North American waterfowl

Krauss

Stallknecht

Slemons

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…It has evolved into 10 genetically distinct hemagglutinin (HA) clades (0-9) and multiple subclades (Smith & Donis, 2015). Long-distance migratory aquatic birds have played a major role in the intercontinental spread of HPAI clade 2 viruses as was seen in spread of H5N1 clade 2.2 in 2005-2006(Olsen et al, 2006 and H5N8 clade 2.3.4.4 Group A or Intercontinental A (2.3.4.4A) in 2014 Marchenko et al, 2015). Previous studies indicated that relay transmission among wild bird population was suspected of being the source of intercontinental transmission because the timing and direction of the outbreak coincided with the migratory route of these aquatic birds (Gaidet et al, 2010;Ramey et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Experimental infection of H5N1 and H5N8 highly pathogenic avian influenza viruses in Northern Pintail (Anas acuta )

Kwon

Lee

Swayne

et al. 2018

Transbound Emerg Dis

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The wide geographic spread of Eurasian Goose/Guangdong lineage highly pathogenic avian influenza (HPAI) clade 2.3.4.4 viruses by wild birds is of great concern. In December 2014, an H5N8 HPAI clade 2.3.4.4 Group A (2.3.4.4A) virus was introduced to North America. Long-distance migratory wild aquatic birds between East Asia and North America, such as Northern Pintail (Anas acuta), were strongly suspected of being a source of intercontinental transmission. In this study, we evaluated the pathogenicity, infectivity and transmissibility of an H5N8 HPAI clade 2.3.4.4A virus in Northern Pintails and compared the results to that of an H5N1 HPAI clade 2.3.2.1 virus. All of Northern Pintails infected with either H5N1 or H5N8 virus lacked clinical signs and mortality, but the H5N8 clade 2.3.4.4 virus was more efficient at replicating within and transmitting between Northern Pintails than the H5N1 clade 2.3.2.1 virus. The H5N8-infected birds shed high titre of viruses from oropharynx and cloaca, which in the field supported virus transmission and spread. This study highlights the role of wild waterfowl in the intercontinental spread of some HPAI viruses. Migratory aquatic birds should be carefully monitored for the early detection of H5 clade 2.3.4.4 and other HPAI viruses.

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“…Outbreaks of the HPAI subtype H5N8 virus of clade 2.3.4.4 in domestic poultry and wild birds were reported in poultry farms and wetlands in January 2014 in South Korea [15]. By summer 2014, the virus was detected in Japan, Beringia and Siberia [16,17]. By the end of 2014, waterfowl migration played an essential role in spreading HPAIV H5N8 in Europe, North America and East Asia [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Genetic characterization of highly pathogenic avian influenza A H5N8 viruses isolated from wild birds in Egypt

Kandeil

Kayed

Moatasim

et al. 2017

Journal of General Virology

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A newly emerged H5N8 influenza virus was isolated from green-winged teal in Egypt during December 2016. In this study, we provide a detailed characterization of full genomes of Egyptian H5N8 viruses and some virological features. Genetic analysis demonstrated that the Egyptian H5N8 viruses are highly pathogenic avian influenza viruses. Phylogenetic analysis revealed that the genome of the Egyptian H5N8 viruses was related to recently characterized reassortant H5N8 viruses of clade 2.3.4.4 isolated from different Eurasian countries. Multiple peculiar mutations were characterized in the Egyptian H5N8 viruses, which probably permits transmission and virulence of these viruses in mammals. The Egyptian H5N8 viruses preferentially bound to avian-like receptors rather than human-like receptors. Also, the Egyptian H5N8 viruses were fully sensitive to amantadine and neuraminidase inhibitors. Chicken sera raised against commercial inactivated avian influenza-H5 vaccines showed no or very low reactivity with the currently characterized H5N8 viruses in agreement with the genetic dissimilarity. Surveillance of avian influenza in waterfowl provides early warning of specific threats to poultry and human health and hence should be continued.

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Influenza A(H5N8) virus isolation in Russia, 2014

Cited by 44 publications

References 11 publications

The enigma of the apparent disappearance of Eurasian highly pathogenic H5 clade 2.3.4.4 influenza A viruses in North American waterfowl

The enigma of the apparent disappearance of Eurasian highly pathogenic H5 clade 2.3.4.4 influenza A viruses in North American waterfowl

Experimental infection of H5N1 and H5N8 highly pathogenic avian influenza viruses in Northern Pintail (Anas acuta )

Genetic characterization of highly pathogenic avian influenza A H5N8 viruses isolated from wild birds in Egypt

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