Influenza A(H1N1)v pandemic in the dialysis population: first wave results from an international survey

Marcelli, Daniele; Marelli, Cristina; Richards, Nick

doi:10.1093/ndt/gfp557

Cited by 47 publications

(30 citation statements)

References 7 publications

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“…[2][3][4][5][6] Results from an international survey for the first wave of pandemic H1N1 influenza in dialysis patients reported a hospitalization rate of 34% and a mortality rate of 5% of infected people, concluding that these patients should be included in first ranks of the priority list for the vaccine. 7 However, citizen's confidence in the new vaccines was poor in many countries, mainly because of concerns about safety, affecting the compliance to the immunization strategy. As a result as of 24 January 2010 only 3.5% (363,000) of the Greek population had been vaccinated against the H1N1 pandemic virus and the situation was similar in other countries as well.…”

Section: Introductionmentioning

confidence: 99%

Pandemic 2009 influenza H1N1 virus vaccination: compliance and safety in a single hemodialysis center

2010

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Background: Acceptance of vaccination against pandemic 2009 H1N1 influenza virus has been poor in some countries, perhaps because of concerns about safety of the new vaccine. Subjects and methods: We prospectively examined vaccination compliance and reasons for nonvaccination in the dialysis patients and the staff of a single hemodialysis unit, after on-site vaccination with a monovalent inactivated adjuvanted H1N1 vaccine. Safety profile was evaluated and compared to that of a control group without chronic kidney disease (CKD). Results: Vaccination acceptance among dialysis patients in our unit was 68% (110/161). Dialysis patients vaccinated against H1N1 had significantly higher compliance with vaccination for seasonal influenza and pneumococcus than those unvaccinated. Three out of 34 (9%) of the unit's staff received the vaccine. Fear of side effects was the main reason for not vaccinating in both groups, while several participants did not consider pandemic influenza a serious disease. At least one adverse reaction was observed in 37/110 (33.6%) of the vaccinated dialysis patients and in 22/42 (52.4%) of the non-CKD control group, p = 0.034. Local mild pain at injection site was the most common side effect of vaccination in both groups. All side effects were of short duration and no serious adverse reactions related to the vaccine or reactions of special interest occurred during the follow-up period. Conclusions: Our findings indicate that immunization against H1N1 virus in dialysis patients is safe and do not support the concerns about safety of the vaccine that was the main reason for nonvaccination in our study.

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Section: Introductionmentioning

confidence: 99%

Pandemic 2009 influenza H1N1 virus vaccination: compliance and safety in a single hemodialysis center

2010

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“…More importantly, infected patients on chronic dialysis treatment were found to have a 10-fold higher mortality rate compared to the general population (Marcelli et al, 2009). Recipients of solid organ transplants have also been suggested to be at risk for more severe disease (Kumar et al, 2010).…”

Section: Infectionsmentioning

confidence: 99%

Medical Evaluation of the Adult Kidney Transplant Candidate

Pham¹,

Pham²,

Pham³

et al. 2013

Current Issues and Future Direction in Kidney Transplantation

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“…The morbidity and mortality associated with infectious diseases is very high in patients undergoing dialysis and renal transplantation [4]. In dialysis patients, the death rate from influenza (H1N1) was reported to be 5%, with the main cause of death being pneumonia [5]. …”

Section: Introductionmentioning

confidence: 99%

Safety and Effectiveness of a 2009 H1N1 Vaccine in Chronic Kidney Disease Children

Akacı¹,

Albayrak²,

Altaş³

2014

Nephron Clin Pract

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Background/Aims: Influenza vaccination is the most effective method for preventing influenza infection and its complications. The risk groups are children with chronic kidney diseases (CKDs) such as children on peritoneal dialysis (PD) and hemodialysis (HD), predialysis CKD (pCKD) and renal transplant (RTx) patients and immunosuppressed children. The aim of the present study was to assess the safety and immunogenicity of a single administration of a monovalent inactivated pandemic (H1N1) 2009 vaccine in children with CKD. Methods: Patients were given a single intramuscular injection of 0.5 ml of monovalent inactivated vaccine. Results: Totally, there were 25 pediatric patients with a diagnosis of CKD (16 PD, 2 HD, 3 pCKD and 4 RTx). Seroconversion was observed in 15 of the 16 patients with PD. Seroconversion occurred in all patients undergoing pCKD and HD. However, 3 of the RTx patients were seronegative. Conclusion: This study demonstrated a high level of immunogenicity and safety of an (H1N1) 2009 influenza vaccine in children with CKD.

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Influenza A(H1N1)v pandemic in the dialysis population: first wave results from an international survey

Abstract: End-stage renal disease patients should be included in first ranks of the priority list for the influenza A (H1N1)v vaccine, as already advocated by some healthcare authorities.

Cited by 47 publications

References 7 publications

Pandemic 2009 influenza H1N1 virus vaccination: compliance and safety in a single hemodialysis center

Pandemic 2009 influenza H1N1 virus vaccination: compliance and safety in a single hemodialysis center

Medical Evaluation of the Adult Kidney Transplant Candidate

Safety and Effectiveness of a 2009 H1N1 Vaccine in Chronic Kidney Disease Children

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