2011
DOI: 10.1016/j.vaccine.2010.12.116
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Influenza A (H1N1) 2009 two-dose immunization of US children: An observer-blinded, randomized, placebo-controlled trial

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Cited by 27 publications
(26 citation statements)
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“…Monovalent, inactivated, non-adjuvanted pandemic 2009 influenza A (H1N1) vaccines have been evaluated in the general population [21], [22], [23], [24]. Randomized placebo-controlled trials have demonstrated that these vaccines are safe and widely immunogenic, with seroprotection rates among healthy adults, adolescents, and the elderly ranging from 94–98%, 94–97%, and 79–93%, respectively, after a single dose of 15 µg of antigen, and greater than 98% among healthy children, after two doses of 15 µg of antigen.…”
Section: Discussionmentioning
confidence: 99%
“…Monovalent, inactivated, non-adjuvanted pandemic 2009 influenza A (H1N1) vaccines have been evaluated in the general population [21], [22], [23], [24]. Randomized placebo-controlled trials have demonstrated that these vaccines are safe and widely immunogenic, with seroprotection rates among healthy adults, adolescents, and the elderly ranging from 94–98%, 94–97%, and 79–93%, respectively, after a single dose of 15 µg of antigen, and greater than 98% among healthy children, after two doses of 15 µg of antigen.…”
Section: Discussionmentioning
confidence: 99%
“…Some evidence in the published literature shows that 1 dose might have provided some protection (37). …”
Section: Methodsmentioning
confidence: 99%
“…After a single dose, 72% of HIV-uninfected children had HAI titers 40; however, only 26% of HIV-uninfected children had baseline HAI titers 40 compared with 45% in HIV-infected children in the current study. In another study of HIV-uninfected children, aged 6 months to 9 years, vaccinated with 15 µg per dose of the same vaccine given to Group C in the current study, 62% had a titer 40 after the first dose [19]. However, only 3%-8% of these HIV-uninfected children had detectable HAI antibody to 2009 H1N1 at baseline.…”
Section: Discussionmentioning
confidence: 42%