Influenza A antigens on human lymphocytes in vitro and probably in vivo

Wilson, Anne B.; Planterose, D. N.; Nagington, J.; Park, Jennifer R.; Barry, Richard D.; Coombs, R.R.A.

doi:10.1038/259582a0

Cited by 28 publications

(8 citation statements)

References 8 publications

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“…3). Thus 26 PFC/106 cells were found in sublingual nodes removed 3 days after infection, and 38 PFC/106 cells were found on day 10. Similar responses were observed in peritracheal nodes, where a significant response was still measured on days 28 and 43. Periaortic nodes showed a peak response at day 10, with a mean PFC count of 150 per 106 cells (range, 14 to 460).…”

Section: Resultssupporting

confidence: 81%

“…This may indicate that homing of lymphocytes from the respiratory tract to the spleen occurs, as no evidence of viremia in influenza infections of ferrets has been presented. Noninfectious virus or viral antigens could also circulate in the blood stream as either free particles or bound to erythrocytes or lymphocytes (28). The PFC response in the spleen was detectable for 43 days after infection and may explain the maintained serum antibody titers.…”

Section: Resultsmentioning

confidence: 99%

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Regional T- and B-cell responses in influenza-infected ferrets

McLaren¹,

Butchko²

1978

Infect Immun

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Ferrets were infected with A/Port Chalmers/72 influenza virus and the T- and B-cell responses in the spleen, in lymph nodes draining the upper and lower respiratory tract, and in lung washings were examined in vitro. Lymphocyte responses were measured by using a hemolytic plaque assay for B cells and a proliferation assay for T cells. Virus and antibody levels were measured in respiratory tract washings, and antibody titers were measured in sera from infected animals. Individual B cells secreting specific antibody to A/Port Chalmers/72 virus were detected in regional lymph node and spleen preparations as early as 3 days and as late as 43 days after infection. T-cell assays showed an in vitro response of lymph node cells to A/Port Chalmers/73 virus from day 6 to day 43. Virus was isolated from the respiratory tract up to 7 days after infection. Serum hemagglutination-inhibiting antibody was first detectable on day 6, with maximum titers reached by day 10. These results demonstrated that antibody production and a cellular immune responses were detectable at regional sites at a time when virus was still present and before serum antibody was measured.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Regional T- and B-cell responses in influenza-infected ferrets

McLaren¹,

Butchko²

1978

Infect Immun

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“…Although efficient influenza replication seems to be limited to the respiratory tract epithelium (Denman & Pinder, 1974), the presence of virus-specific antigens on the peripheral blood lymphocytes of patients suffering from influenza has been observed (Wilson et al, 1976). Moreover, it has been shown that some influenza viruses are mitogenic for lymphocytes (Butchko et al, 1978), and it is now well-established that mitogen-activated lymphocytes are more permissive for replication of a wide variety of RNA and DNA viruses (Woodruff & Woodruff, 1975).…”

Section: Discussionmentioning

confidence: 98%

Secretion of Immunoglobulins by Human Lymphocytes after Infection with Influenza Virus

Dodon¹,

Gazzolo²,

Quash³

et al. 1982

Journal of General Virology

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The biosynthesis of IgM by the Epstein-Barr virus-negative RAMOS lymphoblastoid cell line infected with an influenza A virus, fowl plague virus Dobson strain (FPV-B), was investigated. The results show that FPV infection of RAMOS cells slightly inhibited overall cellular protein synthesis only at 24 h after infection, despite the synthesis of FPV-specific proteins. However, even at this time, the synthesis and secretion of IgM were not affected by virus infection. Secreted IgM contained a reduced amount of sialic acid. The quantity of the asialylated IgM increased proportionally to the amount of enzymically active neuraminidase, suggesting that the asialylation of IgM is due to the action of virus neuraminidase. No such asialylated IgM was observed in RAMOS cells infected with measles virus, which does not possess neuraminidase. These results, together with a previous observation of ours that asialylated immunoglobulins acquire an altered antigenicity, suggest that the modulation of enzyme activities in B lymphocytes in response to an exogenous aggression may lead to disturbances in the structure and in the antigenic properties of immunoglobulins.

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“…In severe natural infections measles virus antigen may be detected in a high percentage of blood monuclear cells (Osunkoya et al, 1974). Moreover, lymphocytes seem to acquire viral antigens even in the course of banal infections by influenza virus (Wilson et al, 1976).…”

Section: Rheumatoid Arthritis a Virus Disease?mentioning

confidence: 99%

Rheumatoid arthritis--a virus disease?

Denman¹

1978

Journal of Clinical Pathology

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Influenza A antigens on human lymphocytes in vitro and probably in vivo

Cited by 28 publications

References 8 publications

Regional T- and B-cell responses in influenza-infected ferrets

Regional T- and B-cell responses in influenza-infected ferrets

Secretion of Immunoglobulins by Human Lymphocytes after Infection with Influenza Virus

Rheumatoid arthritis--a virus disease?

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