Influencing the Effect of Treatment of Diseases Related to Bone Remodelling by Dynamic Loading

Comparison of the Effects of Possible Mechanical Stimuli on the Rate of Biochemical Reactions

“…34 Klika and Mars ˇík demonstrated that the bone remodelling process may be described and simulated when considering the rate of volume variation as the only mechanical stimulation and neglecting shear rate. 35,19,20,36 As was mentioned, tissues are exposed to all variety of mechanical factors: straining, shear, pressure, and even dynamic electric fields, and the results found in this work indicate that the volume variation rate is the most important mechanical stimulus driving the processes in them. antisymmetric part of a tensor T (s) symmetric part of a tensor T ˚(s) symmetric and traceless part of a tensor T (1) , T (2) , T (3) invariants of a tensor T′ a tensor after orthogonal transformation static pressure (can be interpreted as a mechanical energy density) E [1] Lagrangian finite strain tensor D [s -1 ] the rate of deformation tensor u [m] displacement vector x j [m] spatial coordinate D ˚[s -1 ] symmetric and traceless part of tensor D g [J • kg -1 ] specific Gibbs energy…”