The hybrid seed production of practically all farm crops Is attracting more and more attention with every new day. In most plants the production of hybrid seeds economically can become possible only if male sterile lines can be secured from all desired varieties. For this reason the search for male sterile plants is being carried on on a big scale in all parts of the world. Only in recent years over 1000 papers on cytoplasmic male sterility of different plants have been published. Despite this the true nature of cytoplasmic male sterility in plants and in general of cytoplasmic inheritance in all organisms remain a disputed problem. It is incompatible with Mendelian genetics and the chromosome theory of heredity.The aim of this paper is to show that male sterility in plants and even in animals is due to infections by pathogens and that cytoplasmic inheritance and infection genes are a biological impossibility. So far it has experimentally been shown that cytoplasmic male sterility in Datttra, hops, petunia and beets is graft transmissible, i.e. it is caused by viruses. It is further known that a large number of plants become male sterile when infected by some viruses or combinations of viruses.In this paper will be presented observations and preliminary experiments which indicate that male sterility in wheat and sunflower may also be caused by virus infections.Since male sterility in plants is transmitted only by the maternal side and usually does not segregate it has been used from the very beginnmg as the most convincing proof for the existence of extrachromosomal or cytoplasmic inheritance in a large variety of organisms, from bacteria, protozoa and fungi to higher plants and animals. However most of the recent studies on cytoplasmic inheritance show that all classical cases of maternal inheritance (Yeast, Neurospora, Paramaecium, Epilohium, Drosophila) are the result of viral or other infections or symbiosis.In order to assure the production of male sterile plants and the proper use of them we must learn all about the true nature of male sterility and the agents