Influencing factors of weak grip strength and fall: a study based on the China Health and Retirement Longitudinal Study (CHARLS)

Líu, Hao; Hou, Yunfei; Li, Hu; Lin, Jianhua

doi:10.1186/s12889-022-14753-x

Cited by 12 publications

(6 citation statements)

References 67 publications

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“…Some studies have found that knee and/or lower back pain coupled with other painful sites are associated with increased risk of falls [10,13,14]. In our previous study, grip strength was a risk factor of falls [15]. It should be noted that there are limited studies exploring the association between musculoskeletal pain and the risk of falls, most of which were performed in Caucasian populations.…”

Section: Introductionmentioning

confidence: 78%

Association between falls and musculoskeletal pain among middle-aged and older adults: Findings from the China health and retirement longitudinal study

Mei

Xing

et al. 2023

Preprint

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Background Falls are common particularly in elderly people and usually associated with poor prognosis or healing outcomes. Musculoskeletal pain is considered an independent risk factor for falls, by being associated with joint pathology and instability, neuromuscular effects of pain, and changes in cognitive and psychological function. Understanding the relationship between musculoskeletal pain and the risk of falls will help with falls prevention among older adults. Methods A nationally representative sample for the Chinese population was derived from the China Health and Retirement Longitudinal Study (CHARLS). Information on the patients’ demographic characteristics, socioeconomic status, other health-related behavior, as well as history on musculoskeletal pain and falls were obtained. Univariate and multivariate analysis were used to explore the effect factors of falls, including individual factors and musculoskeletal pain factors. P for trend test was performed to examine the trend of each continuous variable. Results Among 18813 respondents, 3697 have experienced a fall. The risk of falls was lower for respondents who were male, lived in urban areas, had higher education level, and were married (P < 0.05). The risk of falls increased with higher age (P < 0.05), as well as for respondents who were still drinking alcohol or who used to drink alcohol at the time of the survey (P < 0.05). The risk of falls also increased for respondents who had suffered from pain in the fingers, waist, legs and knees (P < 0.05), as well as for those who had a higher number of painful sites (P < 0.05). Conclusion Factors including gender, age, education level and health-related behavior may affect the risk of falls. Musculoskeletal pain is one of the factors that could be targeted to help prevent falls in older people.

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Section: Introductionmentioning

confidence: 78%

Association between falls and musculoskeletal pain among middle-aged and older adults: Findings from the China health and retirement longitudinal study

Mei

Xing

et al. 2023

Preprint

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“…Muscle weakness is a significant risk factor for falls [8,29]. A low HGS is generally reported as an indicator of overall muscle strength [30] and does not only increase the fall risk of older adults [11] but also serves as a predictor of dynamic postural balance [31].…”

Section: Discussionmentioning

confidence: 99%

“…Falls have various causes in older people, most notably decreased musculoskeletal function [5], such as muscle weakness. Prior research has consistently revealed a heightened likelihood of falls by individuals presenting with a diminished handgrip strength (HGS) [8][9][10][11]. For instance, in a longitudinal study conducted among residents of mainland China aged 45 years and older, weak grip strength was reported as a risk factor for falls [8].…”

Section: Introductionmentioning

confidence: 99%

“…Prior research has consistently revealed a heightened likelihood of falls by individuals presenting with a diminished handgrip strength (HGS) [8][9][10][11]. For instance, in a longitudinal study conducted among residents of mainland China aged 45 years and older, weak grip strength was reported as a risk factor for falls [8]. Similarly, in a prospective study involving community-dwelling women, reduced grip strength was independently associated with a higher risk of falls in older women [9].…”

Section: Introductionmentioning

confidence: 99%

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Predictive Validity of the Johns Hopkins Fall Risk Assessment Tool for Older Patients in Stroke Rehabilitation

Hong,

Kim,

Choi

2024

Healthcare

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The aim of this retrospective, cross-sectional, observational study was to assess the frequency of falls and evaluate the predictive validity of the Johns Hopkins Fall Risk Assessment Tool (JHFRAT) among patients aged ≥65 years, transferred to the rehabilitation ward of a university hospital. The predictive ability was assessed using receiver operating characteristic curve analysis, and the optimal threshold was established using the Youden index. We analyzed the overall cohort (N = 175) with subacute stroke and the subgroup with a low unaffected handgrip strength (HGS; men: <28 kg, women: <18 kg). Overall, 135/175 patients (77.1%) had a low HGS. The fall rate was 6.9% overall and 5.9% for patients with a low HGS. The JHFRAT predictive value was higher for patients with a low HGS than that for the overall cohort, but acceptable in both. The optimal cutoff score for the overall cohort was 11 (sensitivity, 67%; specificity, 68%), whereas that for the subgroup was 12 (sensitivity, 75%; specificity: 72%). These results are expected to aid nurses working in rehabilitation wards in more effectively utilizing JHFRAT outcomes for post-stroke older patients with a low HGS and contribute to the development of more appropriate fall prevention strategies for high-risk patients in the future.

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“…Notably, frailty often presents as a dysregulated immune response, exacerbating physical vulnerabilities such as diminished grip strength, an increased risk of falls, and a reduced healthy lifespan in older adults [ 7 , 8 , 9 , 10 , 11 ]. The dysregulation of CD4 + T cells has been shown to aggravate chronic proinflammatory cytokine production during aging [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Oxidative Stress Regulates FOXP3+ T-Cell Activity and CD4-Mediated Inflammation in Older Adults with Frailty

Gill,

Bansal,

Guo

et al. 2024

IJMS

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In healthy older adults, the immune system generally preserves its response and contributes to a long, healthy lifespan. However, rapid deterioration in immune regulation can lead to chronic inflammation, termed inflammaging, which accelerates pathological aging and diminishes the quality of life in older adults with frailty. A significant limitation in current aging research is the predominant focus on comparisons between young and older populations, often overlooking the differences between healthy older adults and those experiencing pathological aging. Our study elucidates the intricate immunological dynamics of the CD4/Treg axis in frail older adults compared to comparable age-matched healthy older adults. By utilizing publicly available RNA sequencing and single-cell RNA sequencing (scRNAseq) data from peripheral blood mononuclear cells (PBMCs), we identified a specific Treg cell subset and transcriptional landscape contributing to the dysregulation of CD4+ T-cell responses. We explored the molecular mechanisms underpinning Treg dysfunction, revealing that Tregs from frail older adults exhibit reduced mitochondrial protein levels, impairing mitochondrial oxidative phosphorylation. This impairment is driven by the TNF/NF-kappa B pathway, leading to cumulative inflammation. Further, we gained a deeper understanding of the CD4/Treg axis by predicting the effects of gene perturbations on cellular signaling networks. Collectively, these findings highlight the age-related relationship between mitochondrial dysfunction in the CD4/Treg axis and its role in accelerating aging and frailty in older adults. Targeting Treg dysfunction offers a critical basis for developing tailored therapeutic strategies aimed at improving the quality of life in older adults.

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Influencing factors of weak grip strength and fall: a study based on the China Health and Retirement Longitudinal Study (CHARLS)

Cited by 12 publications

References 67 publications

Association between falls and musculoskeletal pain among middle-aged and older adults: Findings from the China health and retirement longitudinal study

Association between falls and musculoskeletal pain among middle-aged and older adults: Findings from the China health and retirement longitudinal study

Predictive Validity of the Johns Hopkins Fall Risk Assessment Tool for Older Patients in Stroke Rehabilitation

Mitochondrial Oxidative Stress Regulates FOXP3+ T-Cell Activity and CD4-Mediated Inflammation in Older Adults with Frailty

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