Influencing factors analysis for high intensity focused ultrasound ablation in treatment of uterine fibroids

Abstract

This study aims to analyse the influencing factors for High Intensity Focused Ultrasound (HIFU) ablation in treatment of uterine fibroids. Fifty-one uterine fibroids patients with 76 uterine fibroids were enrolled in this study. All patients received the HIFU ablation of uterine fibroids. The treatment efficacy was evaluated. The residual rate of ablation was calculated. The influencing factors related to the treatment outcome of HIFU ablation were analysed. Results showed that, in 76 uterine fibroids, 25 (32.9%) cases obtained effective treatment outcome, with residual rate ≥ 50%, and 51 (67.1%) cases obtained remarkably effective treatment outcome, with residual rate<50%. The treatment outcome had significant difference among subserous, submucous and intramural fibroid type (χ 2 =6.614, P=0.037), among fibroid position of posterior wall, fundus uteri and anterior wall (χ 2 =11.410, P=0.003), between fibroid size of <5 cm and ≥ 5 cm (χ 2 =4.259, P=0.039), and among low, equal and high contrast enhancement (χ 2 =6.153, P=0.046). The logistic regression analysis showed that, the fibroid position was the independent risk factor of treatment outcome, with odds ratio of 2.545 (1.175-5.513). In conclusion, the fibroid type, fibroid position, fibroid size, and contrast enhancement are significantly related to the outcome of HIFU ablation in treatment of uterine fibroids. The fibroid position is the independent risk factor for treatment outcome.