Influencia de la historia natural de la enfermedad en el diagnóstico previo en pacientes con gota

Diagnosis of Chronic Gout: Evaluating the American College of Rheumatology Proposal, European League Against Rheumatism Recommendations, and Clinical Judgment

“…Crystal analysis should always be performed to confirm the diagnosis of gout, particularly in rheumatology departments; unfortunately, in general practitioner (GP) and non-GP daily practice this tool is not routinely employed for several reasons: limits of time in outpatient clinics, lack of availability of polarized light microscopes, the fact that sometimes patients reject the procedure, and technical difficulties, especially during the intercritical period 16,17 . In daily practice most physicians (75-90% of cases), rheumatologists and nonrheumatologists, establish a diagnosis of gout based only on clinical criteria 18,19,20 . CGD items are simple and easy to obtain and make the diagnosis of chronic gout highly accurate, especially for community studies; the frequency of gout has increased in recent decades, and could be very frequent among some sectors of the population 21 .…”

Etiología, fisiopatología, diagnóstico y tratamiento de la gota. Revisión sistemática

“…en sus estudios que la fisiopatología de la gota se debe básicamente a la sobreproducción de urato monosódico a nivel de riñón y la subexcreción de urato monosódico a nivel de los intestinos, representando 2/3 y 1/3 respectivamente. El urato es el resultado final del catabolismo de las purinas, reabsorbiéndose y secretándose a nivel del túbulo proximal, en donde participan los transportadores de urato como URAT1 (SLC22A12) y el GLUT9 (SLC2A9), los cuales juegan un rol importante en el origen genético de la gota (5,6,10).…”