Influencia de la concentración de la lipoproteína(a) en la consecución de objetivos terapéuticos de colesterol LDL en pacientes de alto riesgo cardiovascular. Importancia del colesterol LDL corregido

Arrobas, Teresa; Barco, Antonio; Rico, Miguel Ángel; Iglesia, Reyes de la; Oribe, A.; Cruz, Carmen; Fabiani, F.

doi:10.1016/s0214-9168(10)70002-4

Cited by 1 publication

(1 citation statement)

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“…This pattern deviates from those portrayed by rainwater in healthy subjects [53] and Hernández et al in diabetic patients [54], who both found a positive (Lp(a) − LDL-C) relationship and an inverse (Lp(a) − TAG) relationship. Therefore, future studies should focus on the evaluation of the behavior of Lp(a) with respect to the various types of dyslipidemia, the understanding of molecular mechanisms explaining the proportionality of LDL-C/Lp(a) concentrations, and the therapeutic considerations that may be established for these patients [55]. …”

Section: Discussionmentioning

confidence: 99%

Variations of Lipoprotein(a) Levels in the Metabolic Syndrome: A Report from the Maracaibo City Metabolic Syndrome Prevalence Study

Bermúdez

Rojas

Salazar

et al. 2013

Journal of Diabetes Research

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Background. Lipoprotein(a) [Lp(a)] is a known risk factor for cardiovascular disease, yet its influence on metabolic syndrome (MS) is still controversial. The purpose of this study was to assess the impact generated by this diagnosis in serum Lp(a) concentrations. Materials and Methods. A total of 1807 subjects of both genders (55.3% women and 44.7% men) belonging to the Maracaibo City Metabolic Syndrome Prevalence Study were evaluated. Results were expressed as Mean ± SD, determining differences through Student's t-test and One-Way ANOVA test. Multiple logistic regression models were utilized for analyzing factors associated with elevated serum Lp(a) levels and MS. Total cholesterol and LDL-C were corrected according to Lp(a)-Cholesterol when necessary. Results. No differences were found in Lp(a) values between genders; P = 0,292. The association between MS and the classification of Lp(a) was statistically significant (χ 2 = 28.33; P < 0,0001), with greater levels in subjects with this diagnosis. In the univariate analysis, subjects with each of the separate diagnostic criteria showed higher serum Lp(a) concentrations, except for hyperglycemia. Conclusions. Lp(a) values exhibit important variations regarding MS and each of its components. Impaired fasting glucose appeared as a protecting factor against elevated Lp(a) concentrations, whereas its association with LDL-C and hs-CRP suggests a potential pro-inflammatory role.

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Section: Discussionmentioning

confidence: 99%