“…Cortisol, commonly known as hormone stress, is produced in the adrenal gland and is responsible for the regulation of several physiological processes, including metabolism, immunological response, and female or male reproductive function. High level of cortisol in response to stress, acts directly or indirectly on the reproductive functionality resulting in low reproductive rates ( Chaves et al., 2013 , Kannan et al., 2013 , Tilbrook et al., 2000 ). The rise of cortisol acts on the hypothalamic -pituitary suppressing GnRH secretion, which in turn inhibits FSH release and reduce the LH surge frequency in sheep ( Breen et al., 2005 , Macfarlane et al., 2000 ).…”