Influences of sex and age on serum ascorbic acid.

Sasaki, Ryo; Kurokawa, Toshiko; Kobayasi, T.; Tero‐Kubota, Shozo

doi:10.1620/tjem.140.97

Cited by 16 publications

(8 citation statements)

References 12 publications

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“…Several studies have shown that women tend to have higher plasma vitamin C levels than men (Sasaki et al, 1983;Vanderjagt et al, 1987) and that smokers tend to have lower vitamin C levels than non-smokers (Murata et al, 1989;Preston, 1991), with a significant negative association between vitamin C levels and the number of cigarettes smoked (Sobala et al, 1989). Similar patterns were seen in the present study, both in the population as a whole and in the majority of the individual centres.…”

Section: Discussionsupporting

confidence: 86%

Gastric cancer, gastritis and plasma vitamin C: Results from an international correlation and cross-sectional study

Webb¹,

Bates

Palli

et al. 1997

Int. J. Cancer

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Low intake of foods rich in vitamin C is associated with an increased risk of gastric cancer, and geographic variation in average vitamin C intake, therefore, could explain some of the wide international variation in gastric cancer rates. This multicentre study investigated the relationships between plasma levels of vitamin C, as an indicator of vitamin C intake, and gastric cancer rates, markers of gastritis and other socio‐demographic variables. Fasting plasma samples from about 1,400 individuals from 9 centres in 7 countries worldwide were assayed for total vitamin C using a fluorometric assay. There was no association between average plasma vitamin C levels and either gastric cancer mortality or incidence rates in the populations studied. Therefore, variation in fasting plasma vitamin C levels, as an indicator of consumption of vitamin C, does not appear to explain any of the wide geographic variation in gastric cancer rates. Furthermore, there was no association between plasma vitamin C levels and Helicobacter pylori infection, low serum levels of pepsinogen A (as a marker of severe chronic atrophic gastritis) or the presence of DNA adducts in blood leukocyte DNA. Multivariate models showed that fasting plasma vitamin C levels were associated positively with female sex, higher levels of education, never having smoked and increasing height and negatively with number of cigarettes smoked per day and increasing weight. This suggests not only that gender and tobacco smoking, in particular, are important predictors of plasma vitamin C levels but also that their effects are consistent throughout the developed world. Int. J. Cancer 73:684–689, 1997. © 1997 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 86%

Gastric cancer, gastritis and plasma vitamin C: Results from an international correlation and cross-sectional study

Webb¹,

Bates

Palli

et al. 1997

Int. J. Cancer

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show abstract

“…According to our results, body AA concentrations decrease after menopause in which ovarian hormone production ceases . This finding is in agreement with previous reports in which decreased AA levels were observed with advancing age (2,6,19).…”

Section: Discussionsupporting

confidence: 94%

Evaluation of the Changes in Serum Lipid Profile and Ferritin Concentrations in Relation to Body Ascorbic Acid Status in Healthy Pre- and Postmenopausal Women.

Öner

Mutlu-Türkoglu

Ömer

1997

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe aim of this work was to study the relationship between body ascorbic acid (AA) status and serum lipid profile and ferritin concentrations in healthy pre-and Postmenopausal women. The mean leukocyte and plasma ascorbate values in postmenopausal women were found to be significantly low but within acceptable ranges as compared to premenopausal women. According to these results, plasma and leukocyte AA concentrations decreased after the cessation of ovarian hormone production. In addition, significant increases in total cholesterol, tri glyceride and LDL-cholesterol but a significant decrease in HDL-cho lesterol were observed in postmenopausal women as compared to pre menopausal women. A close positive relationship was found between plasma and leukocyte AA and body iron status in postmenopausal women. The findings were prominent especially in the subgroup of postmenopausal women with low body AA status. Thus, it is concluded that women having low body AA concentrations might have a predispo sition for iron depletion.

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“…In human plasma, the AA content declines with age ( 7 ). Accordingly, the dietary intake of AA influences the amount of this substance in human blood, because humans cannot synthesize AA in vivo.…”

mentioning

confidence: 99%

Ascorbic Acid Levels in Various Tissues, Plasma and Urine of Mice during Aging

Iwama

Amano

Shimokado

et al. 2012

J Nutr Sci Vitaminol

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SummaryHere we quantified ascorbic acid (AA) levels in 14 tissues, plasma and urine of C57BL/6 male mice to track its turnover during 3 to 30 mo of aging. The AA content of adrenal glands and testes decreased somewhat with age, and eventually rose, but increased in the spleen, lungs, eyes and heart. AA levels rose in the liver, skin and skeletal muscles from 6 to 12 mo of age, but declined from 12 to 24 mo. In the cerebellum, cerebrum, small intestine, kidney and plasma, amounts of AA remained almost constant as the animals aged. Most notably, urinary AA decreased markedly until becoming almost undetectable at 24 and 30 mo of age. Collectively, these results, which compare changes in AA levels in specific physiologic targets throughout the aging process, strongly suggest that the AA synthesizing capacity declines over time to become a major factor in senescence-related diseases.

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Influences of sex and age on serum ascorbic acid.

Cited by 16 publications

References 12 publications

Gastric cancer, gastritis and plasma vitamin C: Results from an international correlation and cross-sectional study

Gastric cancer, gastritis and plasma vitamin C: Results from an international correlation and cross-sectional study

Evaluation of the Changes in Serum Lipid Profile and Ferritin Concentrations in Relation to Body Ascorbic Acid Status in Healthy Pre- and Postmenopausal Women.

Ascorbic Acid Levels in Various Tissues, Plasma and Urine of Mice during Aging

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