Influences of Serotonin Hydrochloride on  Adiponectin, Ghrelin and KiSS1 Genes  Expression

Mahmoudi, Fariba; Gollo, Khadijeh Haghighat

doi:10.31661/gmj.v9i0.1767

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Furthermore, Kiss1r mRNA was highly increased in the hypothalamus, hippocampus and cerebellum by 170%, 177% and 131%, respectively ( 92 ). Indeed, these findings are congruent with a previous study demonstrating that intra-cerebroventricular injections of serotonin hydrochloride to male rats significantly enhances hypothalamic kisspeptin expression and resultant circulating LH concentrations ( 93 ). Collectively, these data garner further evidence for the interplay between kisspeptin and the serotonergic system in eliciting antidepressant actions, as well as evidence for the putative brain regions involved.…”

Section: Mood and Emotionssupporting

confidence: 91%

Current Perspectives on Kisspeptins Role in Behaviour

et al. 2022

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The neuropeptide kisspeptin is now well-established as the master regulator of the mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate receptor are also extensively distributed in extra-hypothalamic brain regions. An expanding pool of animal and human data demonstrates that kisspeptin sits within an extensive neuroanatomical and functional framework through which it can integrate a range of internal and external cues with appropriate neuroendocrine and behavioural responses. In keeping with this, recent studies reveal wide-reaching effects of kisspeptin on key behaviours such as olfactory-mediated partner preference, sexual motivation, copulatory behaviour, bonding, mood, and emotions. In this review, we provide a comprehensive update on the current animal and human literature highlighting the far-reaching behaviour and mood-altering roles of kisspeptin. A comprehensive understanding of this important area in kisspeptin biology is key to the escalating development of kisspeptin-based therapies for common reproductive and related psychological and psychosexual disorders.

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Section: Mood and Emotionssupporting

confidence: 91%

Current Perspectives on Kisspeptins Role in Behaviour

et al. 2022

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“…Studies on Iranian adults from 2001 to 2015 indicated that 43% of Iranian people suffer from varying degrees of depression [9]. Among different treatments proposed for depression, the most common ones are tricyclic drugs such as imipramine and amitriptyline, with side effects like drowsiness, agitation, tachycardia, and weight gain [10]. Also, selective serotonin reuptake inhibitors such as fluoxetine and citalopram with nausea and headache as side effects are used [11].…”

Section: Introductionmentioning

confidence: 99%

Anti-depressant Activity of Hydroalcoholic Extract of Asperula odorata L. in Mice

Nemati

Vatani

Abbasy

et al. 2021

GMJ

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Background: The relationship between the treatment of depression and plant-derived substances (e.g., flavonoids, coumarin, and scopoletin) has been demonstrated through interference with the monoamine system. The present study was planned to evaluate the anti-depressant effects of Asperula odorata L. plant through behavioral tests in mice. Material and Methods: In this experimental study, 35 male Syrian mice weighing 30-40 g were examined in five groups (n=7) as follow: received oral distilled water gavage (control), 10 mg/kg of fluoxetine solution gavage (reference standard), 10, 5, and 2.5 mg/kg of A. odorata L. extract gavage (treatment groups). After one week, all behavioral tests, including tail suspension test (TST), forced swimming test (FST), open field test (OFT), elevated plus maze test (EPMT), and fractionation tests were performed each morning for 4-6 h within five days. Results: The hydroalcoholic extract of A. odorata contained phenolic and flavonoid substances (Shinoda test confirmed flavonoid family). Administration of extract (10 and 5 mg/kg doses) versus fluoxetine (10 mg/kg dose) reduced the immobility of animals in both FST and TST (P<0.05). At the OFT, the administered extract increased the number of central square entries of animals with higher mobility (P<0.05). At a 10 mg/kg dose, the active flavonoid ingredients increased the mice's incline to entre and spent more time within no wall parts of EPMT (P<0.05). Conclusion: Our study suggests that the hydroalcoholic extract of A. odorata L. could have significant anti-depressant activity. [GMJ.2021;10:e2206]

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Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility

Göcz

Rumpler

Sárvári

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms underlying this signaling, we thoroughly characterized the estrogen-regulated transcriptome of kisspeptin cells from ovariectomized transgenic mice substituted with 17β-estradiol or vehicle. MBH kisspeptin neurons were harvested using laser-capture microdissection, pooled, and subjected to RNA sequencing. Estrogen treatment significantly ( p.adj . < 0.05) up-regulated 1,190 and down-regulated 1,139 transcripts, including transcription factors, neuropeptides, ribosomal and mitochondrial proteins, ion channels, transporters, receptors, and regulatory RNAs. Reduced expression of the excitatory serotonin receptor-4 transcript ( Htr4 ) diminished kisspeptin neuron responsiveness to serotonergic stimulation. Many estrogen-regulated transcripts have been implicated in puberty/fertility disorders. Patients ( n = 337) with congenital hypogonadotropic hypogonadism (CHH) showed enrichment of rare variants in putative CHH-candidate genes (e.g., LRP1B , CACNA1G , FNDC3A ). Comprehensive characterization of the estrogen-dependent kisspeptin neuron transcriptome sheds light on the molecular mechanisms of ovary–brain communication and informs genetic research on human fertility disorders.

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Influences of Serotonin Hydrochloride on Adiponectin, Ghrelin and KiSS1 Genes Expression

Cited by 4 publications

References 29 publications

Current Perspectives on Kisspeptins Role in Behaviour

Current Perspectives on Kisspeptins Role in Behaviour

Anti-depressant Activity of Hydroalcoholic Extract of Asperula odorata L. in Mice

Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility

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