Influences of polycyclic aromatic hydrocarbon on the epigenome toxicity and its applicability in human health risk assessment

Das, Durgesh Nandini; Ravi, Nathan

doi:10.1016/j.envres.2022.113677

Cited by 43 publications

(15 citation statements)

References 166 publications

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“…Many reviews [48,[62][63][64] have discussed further information regarding the mechanisms of action of PAHs through the AHR pathway, which is considered a hallmark of PAHs toxicity. Some of the PAHs-derivatives can bind covalently to DNA and proteins, generating DNA and protein adducts, which may be responsible for teratogenesis, mutagenesis, and carcinogenesis [65]. Moreover, PAHs change DNA integrity (DNA methylation) and the way it is repaired, which causes genomic integrity to change and increases the risk of cancer and/or death [66].…”

Section: Mechanism Of Pahs Toxicitymentioning

confidence: 99%

Polycyclic Aromatic Aydrocarbons (PAHs) Pollution Approaches in Aquatic Ecosystems: Perils and Remedies Using Green Technologies

El-Bouhy,

Reda,

Mohamed

et al. 2024

Zagazig Veterinary Journal

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One of the most persistent environmental pollutants known as polycyclic aromatic hydrocarbons (PAHs), are pervasive throughout the world. Polycyclic aromatic hydrocarbons pose a serious health threat to a variety of life forms because of their mutagenic, teratogenic, immunotoxicogenic, and/or carcinogenic properties. The majority of PAHs production comes from both natural and human sources, such as forest fires, volcanic emissions, coal, oil, and petroleumbased goods like gasoline. Because PAHs show very high persistence, aquatic and non-aquatic animal species can easily acquire their residues in the environment, either directly from the water or indirectly through their food. Because of this, the current review focuses on the main PAHs emission sources, transformations, occurrences in ecosystems, and harmful effects on aquatic animals, with an emphasis on fish. Also, eco-friendly biological treatment methods for PAHs remediation are thoroughly discussed. These methods include microbial remediation (bacterialremediation, myco-remediation, and vermi-remediation) and Phyto-remediation techniques (active carbons, rhizo-remediation, and medicinal plants).

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Section: Mechanism Of Pahs Toxicitymentioning

confidence: 99%

Polycyclic Aromatic Aydrocarbons (PAHs) Pollution Approaches in Aquatic Ecosystems: Perils and Remedies Using Green Technologies

El-Bouhy,

Reda,

Mohamed

et al. 2024

Zagazig Veterinary Journal

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“…However, it has been scientifically proven 11 that the actual toxicity of engine exhaust gases is determined by the hydrocarbons. Among hydrocarbons, we can distinguish from several dozen to several hundred different compounds which, when present in relatively small amounts, often cause carcinogenic, mutagenic, or genotoxic reactions 12 and their toxicity may be additionally intensified by the phenomenon of additive synergism. When there are several substances in the atmosphere, their combined effects can be equal to the sum of their individual effects but can also be much stronger.…”

Section: Regulated and Unregulated Emissionmentioning

confidence: 99%

The Actual Toxicity of Engine Exhaust Gases Emitted from Vehicles: The Development and Perspectives of Biological and Chemical Measurement Methods

Kęska

2023

ACS Omega

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Most of the current studies on vehicle engine exhaust emissions are focused on qualitative and quantitative measurements. Approval tests for admitting vehicles to traffic and tests performed at vehicle inspection stations are limited to measuring the concentrations of individual compounds or selected groups of compounds. For vehicles with compression-ignition engines, the annual emission control comprises only an exhaust gas opacity test, performed with an opacimeter. This approach does not consider very harmful groups of compounds that determine the toxicity of exhaust gases but are not directly covered by the emission standards, such as polycyclic aromatic hydrocarbons and volatile organic compounds. Also, it does not provide a clear answer to the question of the actual toxicity of exhaust gases, understood as the harmful effect that a given substance causes on living organisms or biological processes. Studies on the actual toxicity of engine exhaust gases present a new area of interest, increasingly more discussed but still not approached in a comprehensive way. The studies include experiments using in vitro biological methods and chemical analyses of gas mixtures. In this Review, I present an overview of current research and a critical comparison of commonly used methods of testing engine exhaust emissions and methods that might supplement them in a significant manner. The development of in vitro biological methods, including methods of microscopic analysis of cells in the assessment of exhaust gas toxicity, provides an innovative approach to the problem of air pollution. This type of research presents the opportunity to indisputably answer the question of the actual toxicity of a given gas mixture and to make a new contribution to science in the field of molecular biology. Current data show that the survival of cells exposed to engine exhaust emissions from older generation vehicles is higher compared to that of newer generation vehicles.

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“…BaP is an efficient agonist of the AhR (aryl hydrocarbon receptor) (Duan et al, 2022), a cytoplasmic receptor extensively expressed in numerous cells, including skin keratinocytes (Kim et al, 2022). Emerging scientific findings propose that the toxic effects attributed to BaP are mediated, at least in part, by AhR activation (Das & Ravi, 2022).…”

Section: Introductionmentioning

confidence: 99%

The aryl hydrocarbon receptor (AhR) activation mediates benzo(a)pyrene‐induced overexpression of AQP3 and Notch1 in HaCaT cells

Almendarez‐Reyna,

de la Trinidad Chacón,

Ochoa‐Martínez

et al. 2023

Environ and Mol Mutagen

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The aim of this study was twofold: (1) evaluate the effect of benzo[a]pyrene (BaP) on expression levels of AQP3 and Notch1 genes in HaCaT cells exposed “in vitro” and (2) investigate the possible biological role of assessed genes by bioinformatics methods. Cells were exposed to increasing concentrations of BaP (0.0–4.0 μM) for 1–4 days. After treatments, cell viability and expression levels of AhR, CYP1A1, AQP3, and Notch1 genes were evaluated. The possible biological role of assessed genes was evaluated using bioinformatics tools. Low cytotoxicity in HaCaT cells dosed with BaP was detected. A significant overexpression (p < .05) of CYP1A1, AQP3, and Notch1 was found in exposed HaCaT cells. The gene expression upregulation was dependent on AhR activation. The bioinformatics analysis showed that these genes were enriched in related cancer signaling pathways. The findings suggest that AQP3 and Notch1 are upregulated by AhR activation in HaCaT cells exposed to BaP.

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Influences of polycyclic aromatic hydrocarbon on the epigenome toxicity and its applicability in human health risk assessment

Cited by 43 publications

References 166 publications

Polycyclic Aromatic Aydrocarbons (PAHs) Pollution Approaches in Aquatic Ecosystems: Perils and Remedies Using Green Technologies

Polycyclic Aromatic Aydrocarbons (PAHs) Pollution Approaches in Aquatic Ecosystems: Perils and Remedies Using Green Technologies

The Actual Toxicity of Engine Exhaust Gases Emitted from Vehicles: The Development and Perspectives of Biological and Chemical Measurement Methods

The aryl hydrocarbon receptor (AhR) activation mediates benzo(a)pyrene‐induced overexpression of AQP3 and Notch1 in HaCaT cells

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