Influences of ozone exposure upon macrophage responsivity to N-formyl-methionyl-leucyl-phenylalanine: mobility and metabolic changes

Klestadt, Deborah; Laval-Gilly, Philippe; Foucaud, Laurent; Falla, Jaı ̈ro

doi:10.1016/j.tiv.2004.08.004

Cited by 4 publications

(2 citation statements)

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“…The THP-l cell line used in this study is considered as a macrophage-like cell model (13). This model has been used to study in vitro the effects of several pollutants on macrophages (19,20). In this study, we exposed endocrine disruptors to differentiated THP-l cells to investigate the mechanism of toxicity underlining the impact of this type of pollutants on immune cells (monocyte/macrophage).…”

Section: Discussionmentioning

confidence: 99%

Effects of 4-Nonylphenol and/or Diisononylphthalate on THP-1 Cells: Impact of Endocrine Disruptors on Human Immune System Parameters

Bennasroune

Rojas

Foucaud

et al. 2012

Int J Immunopathol Pharmacol

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Section: Discussionmentioning

confidence: 99%

Effects of 4-Nonylphenol and/or Diisononylphthalate on THP-1 Cells: Impact of Endocrine Disruptors on Human Immune System Parameters

Bennasroune

Rojas

Foucaud

et al. 2012

Int J Immunopathol Pharmacol

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“…It has been reported that ozone affects cell viability of cultured monocytes (Klestadt et al, 2005). Exposure of PBMC to ozone also caused a dose dependent increase of DNA damage (Diaz-Llera et al, 2002).…”

Section: Discussionmentioning

confidence: 98%

The effect of blood ozonation on mitochondrial function and apoptosis of peripheral blood mononuclear cells in the presence and absence of plasma antioxidants

Plessis¹,

Westhuizen²,

Kotzé³

2007

Afr. J. Biotechnol.

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Ozone-autohemotherapy (O 3 -AHT) has recently gained interest as a form of alternative and complementary medicine. There is, however, some concern regarding its toxicity and effectiveness. Ozone is a powerful oxidant and when introduced into biological fluids react with most cellular components including proteins, lipids and DNA. We assessed the effect of O 3 -AHT on peripheral blood mononuclear cells (PBMC) viability, apoptosis and mitochondrial function in the presence and absence of plasma antioxidants. Exposure to ozone increased lactate dehydrogenase (LDH) release and caspase 3/7 activity in PBMC. A decrease in mitochondrial function was measured as a decrease in ATP levels and an increase in NADH/ NAD + ratio. Complex IV (cytochrome c oxidase) of the respiratory chain was almost completely inhibited by ozone. These results indicated that the death of PBMC was probably through apoptosis. These effects were more evident in the absence of plasma antioxidants. Therefore, high concentrations of ozone were damaging to the cells, but this effect was diminished by antioxidants present in plasma. It is not certain if the in vitro damage will be propagated when ozonated blood is injected back into individuals. One must bear in mind that only a fraction of the total blood volume is ozonated.

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Ozone-induced neurotoxicity: In vitro and in vivo evidence

Singh S.,

Suresh,

Vellapandian

2023

Ageing Research Reviews

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Influences of ozone exposure upon macrophage responsivity to N-formyl-methionyl-leucyl-phenylalanine: mobility and metabolic changes

Cited by 4 publications

References 42 publications

Effects of 4-Nonylphenol and/or Diisononylphthalate on THP-1 Cells: Impact of Endocrine Disruptors on Human Immune System Parameters

Effects of 4-Nonylphenol and/or Diisononylphthalate on THP-1 Cells: Impact of Endocrine Disruptors on Human Immune System Parameters

The effect of blood ozonation on mitochondrial function and apoptosis of peripheral blood mononuclear cells in the presence and absence of plasma antioxidants

Ozone-induced neurotoxicity: In vitro and in vivo evidence

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