Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin

Meinke, Martina C.; Nowbary, Ceylan K.; Schanzer, Sabine; Vollert, Henning; Lademann, Juergen; Darvin, Maxim E.

doi:10.3390/nu9070775

Cited by 25 publications

(23 citation statements)

References 58 publications

(72 reference statements)

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“…Similar findings were observed in a study observing the skin effects of only zeaxanthin both topically and/or orally [144]. Meinke et al recently fortified their prior finding of the beneficial role of carotenoids in the prevention of skin aging by showing that a natural carotenoid-rich extract could prevent the aging-related collagen I degradation in the dermis and improve the ECM [166]. In their study, 29 healthy middle-aged female volunteers received a supplement in the form of a carotenoid-rich natural curly kale extract containing 1650 µg of carotenoids in total (three capsules of 550 µg), once a day for up to 10 months.…”

Section: Carotenoids and Skin Agingsupporting

confidence: 78%

Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?

Balić

Mokos

2019

Antioxidants

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Due to their potential health-promoting effects, carotenoids have drawn both scientific and public attention in recent years. The primary source of carotenoids in the human skin is diet, mainly fruits, vegetables, and marine product, but they may originate from supplementation and topical application, too. In the skin, they accumulate mostly in the epidermis and act as a protective barrier to various environmental influences. Namely, the skin is exposed to numerous environmental factors, including ultraviolet radiation (UVR), air pollution, and smoking, that cause oxidative stress within the skin with consequent premature (extrinsic) aging. UVR, as the most prominent environmental factor, may cause additional detrimental skin effects, such as sunburn, DNA damage, and skin cancer. Therefore, photoprotection is the first line intervention in the prevention of premature aging and skin cancer. Numerous studies have demonstrated that carotenoids, particularly β-carotene, lycopene, lutein, and astaxanthin, have photoprotective effects, not only through direct light-absorbing properties, but also through their antioxidant effects (scavenging reactive oxygen species), as well as by regulation of UV light-induced gene expression, modulation of stress-dependent signaling, and/or suppression of cellular and tissue responses like inflammation. Interventional studies in humans with carotenoid-rich diet have shown its photoprotective effects on the skin (mostly by decreasing the sensitivity to UVR-induced erythema) and its beneficial effects in prevention and improvement of skin aging (improved skin elasticity and hydration, skin texture, wrinkles, and age spots). Furthermore, carotenoids may be helpful in the prevention and treatment of some photodermatoses, including erythropoietic protoporphyria (EPP), porphyria cutanea tarda (PCT) and polymorphous light eruption (PMLE). Although UVR is recognized as the main etiopathogenetic factor in the development of non-melanoma skin cancer (NMSC) and melanoma, and the photoprotective effects of carotenoids are certain, available studies still could not undoubtedly confirm the protective role of carotenoids in skin photocarcinogenesis.

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Section: Carotenoids and Skin Agingsupporting

confidence: 78%

Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?

Balić

Mokos

2019

Antioxidants

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“…The more recent link between nutrition and skin aging began in earnest around the year 2000 with the demonstrated increase in peer-reviewed scientific journal reports on this topic [ 12 ]. Thus, the application of: (a) topical administration from outside to inside the skin and (b) the inside by oral consumption of nutritionals to the outer skin layers is now common place and many journal reports exhibit significant improvement for both on a variety of dermal parameters [ 11 , 13 , 14 , 15 , 16 , 17 ]. This review covers, where applicable, the history, chemical structure and sources, biological and biomedical properties in the skin, and, lastly, animal and clinical data on the oral applications of: (a) collagen, (b) ceramide, (c) β-carotene, (d) astaxanthin, (e) coenzyme Q 10 , (f) colostrum, (g) zinc, and (h) selenium in their mode of action or function in improving skin health and various dermal endpoints.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Vollmer¹,

West²,

Lephart

2018

IJMS

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The history of cosmetics goes back to early Egyptian times for hygiene and health benefits while the history of topical applications that provide a medicinal treatment to combat dermal aging is relatively new. For example, the term cosmeceutical was first coined by Albert Kligman in 1984 to describe topical products that afford both cosmetic and therapeutic benefits. However, beauty comes from the inside. Therefore, for some time scientists have considered how nutrition reflects healthy skin and the aging process. The more recent link between nutrition and skin aging began in earnest around the year 2000 with the demonstrated increase in peer-reviewed scientific journal reports on this topic that included biochemical and molecular mechanisms of action. Thus, the application of: (a) topical administration from outside into the skin and (b) inside by oral consumption of nutritionals to the outer skin layers is now common place and many journal reports exhibit significant improvement for both on a variety of dermal parameters. Therefore, this review covers, where applicable, the history, chemical structure, and sources such as biological and biomedical properties in the skin along with animal and clinical data on the oral applications of: (a) collagen, (b) ceramide, (c) β-carotene, (d) astaxanthin, (e) coenzyme Q10, (f) colostrum, (g) zinc, and (h) selenium in their mode of action or function in improving dermal health by various quantified endpoints. Lastly, the importance of the human skin microbiome is briefly discussed in reference to the genomics, measurement, and factors influencing its expression and how it may alter the immune system, various dermal disorders, and potentially be involved in chemoprevention.

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“…The ECM of the dermis consists of collagen and is produced by fibroblasts (15). In particular, type I collagen is the most prevalent of the fibril-forming collagens (16,17). Matrix metalloproteinase-8 (MMP-8), a zinc-dependent endopeptidase, is present at sites of acute inflammation and potently degrades type I collagen (18,19).…”

Section: Introductionmentioning

confidence: 99%

Crude protein from spirulina increases the viability of CCD‑986sk cells via the EGFR/MAPK signaling pathway

et al. 2018

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Spirulina, an edible blue-green alga, has great potential for various applications in human health, possibly including reduced skin aging. The mechanisms by which spirulina crude protein (SPCP) may influence human skin fibroblast viability are not yet understood; therefore, a human dermal fibroblast cell line (CCD-986sk) was used as a cell model system to study the influence of SPCP on human skin fibroblast viability. An enzyme-linked immunosorbent assay showed that collagen formation improved in SPCP-treated cells in a dose-dependent manner, while elastase activity was decreased. In addition, western blot analysis showed a dose-dependent decrease in the expression of the aging-associated gene matrix metalloproteinase-8, a collagen-degradative enzyme. It was also shown that SPCP upregulated epidermal growth factor receptor (EGFR) activity, leading to activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway. Together, these results demonstrated that SPCP increases human fibroblast viability by activation of the EGFR/MAPK signaling pathway. This contribution sheds light on the molecular mechanism for SPCP increasing the viability of human skin cell and provides a potential efficient cosmeceutical for protecting human skin.

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Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin

Cited by 25 publications

References 58 publications

Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?

Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Crude protein from spirulina increases the viability of CCD‑986sk cells via the EGFR/MAPK signaling pathway

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