Influences of lipid and non‐lipid nutritional parameters on factor VII coagulant activity in normal subjects: the Nove Study

Abstract

Abstract.Community-based studies have suggested that the dietary intake of total fat influences factor VII coagulant activity (FVII c ), a predictor of fatal events from coronary heart disease (CHD). Nevertheless, the question whether the quality of dietary fats, with special reference to fatty acids (FAs), influences FVII c is unsolved. The authors investigated in 90 healthy volunteers living in Nove, a village near Vicenza (northern Italy), the relationships between FVII c and the plasma concentration of individual FAs. Several indices of other nutritional factors that have recently received increasing attention as determinants of CHD risk (antioxidant vitamins A and E, oligoelements) were also included in the multivariate analysis. The stepwise multiple linear regression analysis revealed body mass index (BMI), and the concentrations of plasma stearic acid (C 18 : 0 ) and serum copper as significant independent predictors of a substantial proportion of FVII c variability (R 0 . 52; R 2 0 . 27; P < 0 . 001). This study substantially supports the role of the plasma concentration of stearic acid as an important factor in modulating FVII c .

Influence of stearic acid on postprandial lipemia and hemostatic function

“…A relationship between total fat intake and FVII c was reported, and a reduction in fat intake resulted in a marked decline in FVII c . An association was found between the proportion of stearic acid in plasma FFA and FVII c (7,8). Stearic acid and the trans FA elaidic acid (18:1 trans), but not oleic acid (9), were found to increase FVII c activation in vitro, and stearic acid has been postulated to activate factor XII, and hence FVII c , by forming a negatively charged contact surface on TAG-rich lipoproteins.…”

Diet and blood coagulation factor VII—a key protein in arterial thrombosis

“…A positive association between the saturated fatty acid content of phospholipids and FVIIc, and an inverse relationship between linoleic acid and FVIIc was observed. In a similar study, Girelli and coworkers found a positive association between plasma lipid contents of saturated fatty acids, notably stearic acid, and FVIIc (Girelli et al, 1996). Vegetarianism has been studied by two groups and they reached con¯icting conclusions Pan et al, 1993).…”

“…These ®ndings demonstrate the importance of FVII in haemostasis. The impact of FVIIc in human thrombogenesis was suggested by the ®nding of positive associations between FVIIc and prothrombin fragment 1 2 (F1 2) (Miller et al, 1996b;Gouin-Thibault et al, 1996), and by the rise in F1 2 that follows infusion of recombinant FVIIa in FVII-de®cient patients . More direct evidence comes from animal experiments showing that inhibition of the TF pathway causes less ®brin formation and thrombogenesis following intimal injuries of the arteries (Speidel et al, 1996;Jang et al, 1995;Arnljots et al, 1997).…”