Influences of housing conditions and ethanol intake on binding characteristics of D2, 5-HT1A, and benzodiazepine receptors of rats

Rilke, Olaf; May, Torsten; Oehler, Jochen; Wolffgramm, Jochen

doi:10.1016/0091-3057(95)00093-c

Cited by 39 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings suggest that exposure to environmental variables associated with the attainment of dominance produced alterations in D 2 receptor levels that impacted the reinforcing effects of cocaine. Consistent with these findings in monkeys, others have reported similar alterations in the physiology of brain DA systems in rats raised in social groups ("enriched" environments) versus those that were individually housed ("isolated"; Bowling et al 1993;Rilke et al 1995Rilke et al , 1998. Moreover, "enriched" rodents are less sensitive to the behavioral effects of cocaine and amphetamine, including locomotor-stimulant (Bardo et al 1995), discriminative stimulus (Fowler et al 1993) and reinforcing effects (Green et al 2002).…”

Section: Introductionsupporting

confidence: 62%

Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine

et al. 2004

View full text Add to dashboard Cite

These results suggest that D(1) receptor function is not substantially influenced by social rank in monkeys from well-established social groups. While an earlier study showed that dominant monkeys had higher D(2) receptor levels and were less sensitive to the reinforcing effects of cocaine during initial exposure, the present findings indicate that long-term cocaine use changed D(2) receptor levels such that D(2) receptor function and cocaine reinforcement were not different between social ranks. These findings suggest that cocaine exposure attenuated the impact of social housing on DA receptor function.

show abstract

Section: Introductionsupporting

confidence: 62%

Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Therefore, we selected subjects who met these criteria for our study. Of course, this reasoning also suggests that the population of individuals with a positive family history and who are alcoholic themselves may lack protective factors, but we did not select this group as a comparison because long-term alcohol use can alter striatal D 2 receptor expression, 26 which would interfere with the identification of variables that protect against alcoholism.…”

Section: G Enetic Factors Have Amentioning

confidence: 98%

High Levels of Dopamine D2 Receptors in Unaffected Members of Alcoholic Families

Volkow

Wang²,

Begleiter³

et al. 2006

Arch Gen Psychiatry

320

189

View full text Add to dashboard Cite

The higher-than-normal D(2) receptor availability in nonalcoholic members of alcoholic families supports the hypothesis that high levels of D(2) receptors may protect against alcoholism. The significant associations between D(2) receptors and metabolism in frontal regions involved with emotional reactivity and executive control suggest that high levels of D(2) receptors could protect against alcoholism by regulating circuits involved in inhibiting behavioral responses and in controlling emotions.

show abstract

“…On the other hand, no differences in D1-like and D2-like DA receptor density were found between isolated animals, group-housed animals, and animals that were raised in a enriched conditions between 30 and 60 days of age (Bardo & Hammer, 1991). Other studies showed reduced D1-like and D2-like DA receptor density in the striatum and nucleus accumbens of isolated animals (Rilke et al, 1995;Bean & Lee, 1991). Moreover, the downregulation of D2-like DA receptors was blocked by chronic haloperidol treatment (Bean & Lee, 1991).…”

Section: Dopamine Function In Socially and Maternally Deprived Animalsmentioning

confidence: 82%

“…In addition, isolated rats was shown to acquire sensitization to amphetamine at a lower dose than that of animals that have been raised in groups; the behavioral response to amphetamine following a stressor (footshock) was also higher in isolated animals (Ahmed et al, 1995). Then, other studies reported no change in DA receptor affinity following prolonged social deprivation Rilke, May, Oehler, & Wolffgramm, 1995;Guisado, Fernandez-Tome, Garzon, & Del Rio, 1980). Furthermore, no differences in the effects of D 1 (SKF 38393) and D 2 (quinpirole) DA agonists on cyclic AMP accumulation in the caudate-putamen was found following isolation (Jones et al, 1992).…”

Section: Dopamine Function In Socially and Maternally Deprived Animalsmentioning

confidence: 89%

Social Deprivation, Social–Emotional Behavior, and the Plasticity of Dopamine Function

Gendreau

Lewis

2005

Developmental Psychobiology of Aggression

View full text Add to dashboard Cite

brain plasticity and social developmentThe notion of plasticity in relation to biological and behavioral development is not a new one. Even when very little was known about brain structure and function and long before the advent of modern molecular and neuroanatomical techniques, scientists recognized that the brain had the capacity to adapt and change in response to environmental input. Already in 1892, William James stressed the importance of brain plasticity in the organization of habits:Plasticity, then, in the wide sense of the word, means the possession of a structure weak enough to yield to an influence, but strong enough not to yield all at once. Each relatively stable phase of equilibrium in such a structure is marked by what we call a new set of habits. Organic matter, especially nervous tissue, seems endowed with a very extraordinary degree of plasticity of this sort; so that we may without hesitation lay down as our first proposition the following: that the phenomena of habit in living beings are due to plasticity of the organic materials of which their bodies are composed. (p. 2, italic original ( James, 1892)

show abstract

Influences of housing conditions and ethanol intake on binding characteristics of D2, 5-HT1A, and benzodiazepine receptors of rats

Cited by 39 publications

References 35 publications

Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine

Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine

High Levels of Dopamine D2 Receptors in Unaffected Members of Alcoholic Families

Social Deprivation, Social–Emotional Behavior, and the Plasticity of Dopamine Function

Contact Info

Product

Resources

About