On the basis that entrepreneurial knowledge spurs innovation and, in turn, generates a competitive advantage, the research seeks to explore the key "imperfections" of innovation process due to the dynamic, current technological progress in the knowledge intensive sector. The "imperfections" identified in risk management, asymmetric information in the knowledge management process, and holdup problems, can all disrupt collaborative partnerships and limit opportunities for innovation. Design/methodology/approach By offering a case study analysis on two small to medium enterprises one operating in the United Kingdom and the other one in Italy, the study explores three key imperfections: risk management, asymmetric information in the knowledge management process, and holdup problems which occur in the innovation process. Finding The entrepreneurs face these imperfections by adopting an open innovation model. Notwithstanding both entrepreneurs had to deal with all "imperfections", their skills attributes, attitude, and aptitude allow them to grow their business and continually develop new products. Therefore, the imperfections do not limit the innovative capacity of an entrepreneur but rather enhance their challengeable attitude. In this regard, the case studies induce a further analysis on entrepreneurial knowledge intertwined with entrepreneurial risk management and networking skills. Research limitations/implications The empirical significance of two cases does not allow theorization. However, the research offers interesting results which can be strengthened by a comparative case study with other countries or deep investigated by a quantitative approach. Originality/value By leveraging entrepreneurial knowledge the imperfections noted in the innovation process can be overcome. Entrepreneurial knowledge is recognised as the main asset of an enterprise if it is combined with external talent or human resources. Entrepreneurs aim to develop innovative approaches and ideas through establishing both formal and informal collaborative partnerships relationships which are employed thanks to the entrepreneurs' networking skills, knowledge, and abilities.