Influences of bovine colostrum on nasal swab microbiome and viral upper respiratory tract infections – A case report

Alsayed, Ahmad R.; Al-Doori, Abdulhameed; Al-Dulaimi, Abdullah; Alnaseri, Abdullah; Abuhashish, Juhayna; Aliasin, Khaled; Alfayoumi, Ibrahim

doi:10.1016/j.rmcr.2020.101189

Cited by 23 publications

(29 citation statements)

References 12 publications

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“…HRV detection was performed according to a recent publication. 29 The absolute quantification / second derivative maximum strategy was used to analyze the samples. A positive result was registered for C t values less than or equal to 40 cycles, while a negative result was registered in the absence of a C t value and for C t values were greater than 40 cycles.…”

Section: Clinical Samples and Detection Of Sars-cov-2 And Hrvmentioning

confidence: 99%

Investigating the human rhinovirus co-infection in patients with asthma exacerbations and COVID-19

et al. 2022

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Objective: To investigate the co-infections with human rhinovirus (HRV) among patients with asthma exacerbation and COVID-19 in Jordan. Also, to determine the frequency of acute asthma exacerbation before and during the COVID-19 pandemic on a matched basis. Methods: The data of this prospective cohort research consisted of clinical variables. During the first visit, and after 14-days, nasopharyngeal swabs were taken and the quantitative polymerase chain reaction was performed for HRV and SARS-CoV-2 detection. Results: Forty-seven out of 175 (26.9%) COVID-19 adult cases have been diagnosed with asthma. The number of asthma exacerbations among the study participants was higher during 2021 than in 2020 (p=0.035). Most of the included asthmatic participants (61.7%) were only positive for SARS-CoV-2 and 38.3% were co-infected with HRV. The SARS-CoV-2 cycle threshold value was lower in samples infected with both viruses compared to samples infected with SARS-CoV-2 alone, p<0.005. Conclusion: Our findings indicate that HRV and SARS-CoV-2 were significantly more prevalent in asthma exacerbations than stable asthma. Thus, HRV and/or SARS-CoV-2 infections were potentially cofactors or contributors to the asthma exacerbation in this cohort. This is the first study, in Jordan, to investigate the HRV co-infection in COVID-19 asthmatic patients and HRV could be related with a higher severity of COVID-19.

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Section: Clinical Samples and Detection Of Sars-cov-2 And Hrvmentioning

confidence: 99%

Investigating the human rhinovirus co-infection in patients with asthma exacerbations and COVID-19

et al. 2022

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“…A case study presented by Alsayed et al [ 29 ] showed the effectiveness of BC in preventing upper respiratory tract infection (URTI) and nasal swab microbiome caused by respiratory viruses in an adult. This study was conducted on a 27-year-old patient who was a nonsmoker and nonalcoholic and took a healthy diet with supplementation in three periods: period a, 1 g of bovine colostrum (two capsules, each 500 mg) for 4 weeks; period b, 2 weeks after the end of the period a, 1 g BC at dawn for 3 days; period c, after period b, supplemented with 1 g BC at dawn 2 times/week for 4 weeks.…”

Section: Current Evidence Of Therapeutic Use Of Bcmentioning

confidence: 99%

“…Recently, the approaches of exploring BC-based feed for feeding fish [ 26 ], broiler chickens [ 27 ], and birds [ 28 ] have been reported in the literature, and it has been demonstrated to be successful in delivering a suitable high protein content for overall body composition. Scientific evidence from placebo-controlled clinical trials indicates that BC components have a wide range of pharmacological uses in the prevention and pretreatment of acute and chronic diseases [ 29 , 30 ]. Figure 1 depicts an outline of the elements of bovine colostrum, as well as their health and industrial uses.…”

Section: Introductionmentioning

confidence: 99%

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements

et al. 2022

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Bovine colostrum (BC) is the initial mammary secretion after parturition, which is nature’s bountiful source consisting of nutritional and bioactive components present in a highly concentrated low-volume format. All mammalian newborns require colostrum to enhance physiological processes such as lifelong immunity, gastrointestinal development, and resistance to microbial infections. The genetic, environmental, and processing methods can all have an impact on the biochemical contents of BC and its supplements. BC and its derivatives have been intensively researched for their potential use in functional foods, medicines, and animal feed. Evidence from clinical studies suggests that BC products are well-tolerated, nontoxic, and safe for human ingestion. Functional foods, feed, and pharmaceutical formulations based on bovine colostrum are playing noteworthy roles in the development of innovative products for promoting health and the prevention of chronic illnesses. This systematic review sheds light on recent research on (a) the effects of processing techniques on BC components, (b) emerging techniques used in the isolation and identification of novel components, (c) BC-based functional foods for human consumption and animal feed supplements, and (d) the role of BC in current drug delivery, as well as future recommendations.

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“…Saad et al [30] have reported that colostrum has both antimicrobial and endotoxinneutralizing effects. Thus, it can be effective in the prophylaxis of recurrent upper respiratory tract infections and diarrhea [30,31]. The consumption of bovine colostrum can also lead to changes in the respiratory microbiome, which was shown by nasal swab samples [31].…”

Section: Bioactive Components In Colostrum 21 Bioactive Compoundsmentioning

confidence: 99%

Bovine Colostrum for Human Consumption—Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing

Fasse

Alarinta

Frahm

et al. 2021

Dairy

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The main purpose of bovine colostrum, being the milk secreted by a cow after giving birth, is to transfer passive immunity to the calf. The calves have an immature immune system as they lack immunoglobulins (Igs). Subsequently, the supply of good quality bovine colostrum is required. The quality of colostrum is classified by low bacterial counts and adequate Ig concentrations. Bacterial contamination can contain a variety of human pathogens or high counts of spoilage bacteria, which has become more challenging with the emerging use of bovine colostrum as food and food supplements. There is also a growing risk for the spread of zoonotic diseases originating from bovines. For this reason, processing based on heat treatment or other feasible techniques is required. This review provides an overview of literature on the microbial quality of bovine colostrum and processing methods to improve its microbial quality and keep its nutritional values as food. The highlights of this review are as follows: high quality colostrum is a valuable raw material in food products and supplements; the microbial safety of bovine colostrum is increased using an appropriate processing-suitable effective heat treatment which does not destroy the high nutrition value of colostrum; the heat treatment processes are cost-effective compared to other methods; and heat treatment can be performed in both small- and large-scale production.

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Influences of bovine colostrum on nasal swab microbiome and viral upper respiratory tract infections – A case report

Cited by 23 publications

References 12 publications

Investigating the human rhinovirus co-infection in patients with asthma exacerbations and COVID-19

Investigating the human rhinovirus co-infection in patients with asthma exacerbations and COVID-19

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements

Bovine Colostrum for Human Consumption—Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing

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