Influences of Arthropod Vectors on Encephalitic Arboviruses

Higgs, Stephen; Vanlandingham, Dana L.

doi:10.1007/978-3-319-33189-8_11

Cited by 6 publications

(9 citation statements)

References 137 publications

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“…YF in turn has connectivity to both the tick and mosquito borne viruses, which subdivide into well separated clusters according to their disease phenotype. The close relationship of the tick born viruses to one another suggests that their ancestry is relatively recent, or that other factors in the tick life cycle may constrain their evolution rate (46)(47)(48). The distinct properties of the tick vs the mosquito born viruses (49,50) illustrated by their neatly defined clusters, reflects these influences.…”

Section: Discussionmentioning

confidence: 99%

D-graph clusters flaviviruses and β-coronaviruses according to their hosts, disease type and human cell receptors

Braun¹,

Schein

Braun

2020

Preprint

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Motivation: There is a need for rapid and easy to use, alignment free methods to cluster large groups of protein sequence data. Commonly used phylogenetic trees based on alignments can be used to visualize only a limited number of protein sequences. DGraph, introduced here, is a dynamic programming application developed to generate 2D-maps based on similarity scores for sequences. The program automatically calculates and graphically displays property distance (PD) scores based on physico-chemical property (PCP) similarities from an unaligned list of FASTA files. Such PD-graphs show the interrelatedness of the sequences, whereby clusters can reveal deeper connectivities. Results: PD-Graphs generated for flavivirus (FV), enterovirus (EV), and coronavirus (CoV) sequences from complete polyproteins or individual proteins are consistent with biological data on vector types, hosts, cellular receptors and disease phenotypes. PD-graphs separate the tick- from the mosquito-borne FV, clusters viruses that infect bats, camels, seabirds and humans separately and the clusters correlate with disease phenotype. The PD method segregates the β-CoV spike proteins of SARS, SARS-CoV-2, and MERS sequences from other human pathogenic CoV, with clustering consistent with cellular receptor usage. The graphs also suggest evolutionary relationships that may be difficult to determine with conventional bootstrapping methods that require postulating an ancestral sequence.

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Section: Discussionmentioning

confidence: 99%

D-graph clusters flaviviruses and β-coronaviruses according to their hosts, disease type and human cell receptors

Braun¹,

Schein

Braun

2020

Preprint

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“…Arboviruses can also cause other non-specific symptoms which are observed in most viral infections, such as rash and myalgia. Specific clinical manifestations can be generally classified into distinct categories of clinical outcomes: hemorrhagic fever, encephalitis or central nervous system involvement, or arthritis (Barrett and Higgs, 2007; Higgs, 2008; Higgs and Vanlandingham, 2016). The possibility of further development of severe disease is dependent on the arbovirus and the physiological and immunological condition of the patient.…”

Section: Arboviruses Transmission and Human Diseasesmentioning

confidence: 99%

“…aegypti , is present in large numbers (Calisher and Woodall, 2016). The other important form of severe disease in humans is encephalitis and related central nervous system diseases caused by several arboviruses from different virus families (Higgs and Vanlandingham, 2016). For example, members of flaviviruses within the Japanese encephalitis virus and TBEV complexes are known to cause encephalitic diseases in humans (Higgs and Vanlandingham, 2016).…”

Section: Arboviruses Transmission and Human Diseasesmentioning

confidence: 99%

“…The other important form of severe disease in humans is encephalitis and related central nervous system diseases caused by several arboviruses from different virus families (Higgs and Vanlandingham, 2016). For example, members of flaviviruses within the Japanese encephalitis virus and TBEV complexes are known to cause encephalitic diseases in humans (Higgs and Vanlandingham, 2016). Similarly, infection of New World alphaviruses such as Venezuelan equine encephalitis virus and Eastern equine encephalitis virus also cause encephalitis in humans.…”

Section: Arboviruses Transmission and Human Diseasesmentioning

confidence: 99%

“…A recent review by Higgs et al (2017), describes mosquito modulation of arbovirus-host interaction, whilst Higgs and Vanlandingham (2016) compare and contrast ticks and mosquitoes with an emphasis on tick-borne transmission. Although many of the proteins present in mosquito saliva have unknown functions, there are others that are known to alter normal physiological functions of the host which facilitates the acquisition of blood meals.…”

Section: Vector-host Interactions and Their Impact On Transmission Anmentioning

confidence: 99%

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Arbovirus-Mosquito Vector-Host Interactions and the Impact on Transmission and Disease Pathogenesis of Arboviruses

2019

Self Cite

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Hundreds of viruses, designated as arboviruses, are transmitted by arthropod vectors in complex transmission cycles between the virus, vertebrate host, and the vector. With millions of human and animal infections per year, it is critical to improve our understanding of the interactions between the biological and environmental factors that play a critical role in pathogenesis, disease outcomes, and transmission of arboviruses. This review focuses on mosquito-borne arboviruses and discusses current knowledge of the factors and underlying mechanisms that influence infection and transmission of arboviruses and discusses critical factors and pathways that can potentially become targets for intervention and therapeutics.

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Vector-Borne Viral Diseases as a Current Threat for Human and Animal Health—One Health Perspective

Socha

Kwasnik

Larska

et al. 2022

JCM

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Over the last decades, an increase in the emergence or re-emergence of arthropod-borne viruses has been observed in many regions. Viruses such as dengue, yellow fever, or zika are a threat for millions of people on different continents. On the other hand, some arboviruses are still described as endemic, however, they could become more important in the near future. Additionally, there is a group of arboviruses that, although important for animal breeding, are not a direct threat for human health. Those include, e.g., Schmallenberg, bluetongue, or African swine fever viruses. This review focuses on arboviruses and their major vectors: mosquitoes, ticks, biting midges, and sandflies. We discuss the current knowledge on arbovirus transmission, ecology, and methods of prevention. As arboviruses are a challenge to both human and animal health, successful prevention and control are therefore only possible through a One Health perspective.

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Influences of Arthropod Vectors on Encephalitic Arboviruses

Cited by 6 publications

References 137 publications

D-graph clusters flaviviruses and β-coronaviruses according to their hosts, disease type and human cell receptors

D-graph clusters flaviviruses and β-coronaviruses according to their hosts, disease type and human cell receptors

Arbovirus-Mosquito Vector-Host Interactions and the Impact on Transmission and Disease Pathogenesis of Arboviruses

Vector-Borne Viral Diseases as a Current Threat for Human and Animal Health—One Health Perspective

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