Influences of Ag-NPs doping chitosan/calcium silicate nanocomposites for optical and antibacterial activity

Nahrawy, Amany M. El; Ahmed, A. Razzaque; Hammad, Ali B. Abou; Youssef, Ahmed M.

doi:10.1016/j.ijbiomac.2016.08.045

Cited by 80 publications

(26 citation statements)

References 42 publications

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“…132 Chitosan/ calcium silicate nanocomposites doped with Ag + exhibited antibacterial activity against S. aureus and P. aeruginosa. 133 Ag NPs capped with lipoic acid were effective against Staphylococcus epidermidis and Streptococcus mutans biofilm. 134 Ag-decorated poly (DL-lactide-co-glycolide) NPs exhibited high efficacy against S. epidermidis biofilms.…”

Section: Polymeric Nanocomposites and Nanomaterials Conjugated With Amentioning

confidence: 99%

Nanomaterials for alternative antibacterial therapy

Hemeg

2017

IJN

428

262

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Despite an array of cogent antibiotics, bacterial infections, notably those produced by nosocomial pathogens, still remain a leading factor of morbidity and mortality around the globe. They target the severely ill, hospitalized and immunocompromised patients with incapacitated immune system, who are prone to infections. The choice of antimicrobial therapy is largely empirical and not devoid of toxicity, hypersensitivity, teratogenicity and/or mutagenicity. The emergence of multidrug-resistant bacteria further intensifies the clinical predicament as it directly impacts public health due to diminished potency of current antibiotics. In addition, there is an escalating concern with respect to biofilm-associated infections that are refractory to the presently available antimicrobial armory, leaving almost no therapeutic option. Hence, there is a dire need to develop alternate antibacterial agents. The past decade has witnessed a substantial upsurge in the global use of nanomedicines as innovative tools for combating the high rates of antimicrobial resistance. Antibacterial activity of metal and metal oxide nanoparticles (NPs) has been extensively reported. The microbes are eliminated either by microbicidal effects of the NPs, such as release of free metal ions culminating in cell membrane damage, DNA interactions or free radical generation, or by microbiostatic effects coupled with killing potentiated by the host’s immune system. This review encompasses the magnitude of multidrug resistance in nosocomial infections, bacterial evasion of the host immune system, mechanisms used by bacteria to develop drug resistance and the use of nanomaterials based on metals to overcome these challenges. The diverse annihilative effects of conventional and biogenic metal NPs for antibacterial activity are also discussed. The use of polymer-based nanomaterials and nanocomposites, alone or functionalized with ligands, antibodies or antibiotics, as alternative antimicrobial agents for treating severe bacterial infections is also discussed. Combinatorial therapy with metallic NPs, as adjunct to the existing antibiotics, may aid to restrain the mounting menace of bacterial resistance and nosocomial threat.

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Section: Polymeric Nanocomposites and Nanomaterials Conjugated With Amentioning

confidence: 99%

Nanomaterials for alternative antibacterial therapy

Hemeg

2017

IJN

428

262

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“…into a range of polymers. The incorporated nanollers were reported to upgrade and diversify polymer materials properties such as excellent mechanical strength and toughness, 11,12 high thermal stability, 13 low water/gas permeability, 14,15 good optical features, [16][17][18] ame retardancy 19 ultraviolet (UV)-shielding 20 and dielectric properties. 21 Metal-organic frameworks (MOFs) are a class of crystalline porous materials with periodic network structures that are usually formed by self-assembly of inorganic metal centers (metal ions or metal clusters) and organic ligands.…”

Section: Introductionmentioning

confidence: 99%

Enhanced mechanical, thermal, and UV-shielding properties of poly(vinyl alcohol)/metal–organic framework nanocomposites

et al. 2018

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“…Silver nanoparticles (Ag-NPs) display good antimicrobial efficiency against bacteria and eukaryotic microorganisms, so it played a major role in the field of nanotechnology and nanomedicine [13][14][15]. Silver is particularly important because of its characteristic properties such as high conductivity, antibacterial and catalytic activities beside the chemical stability.…”

Section: Alkylmentioning

confidence: 99%

Preparation and Characterization of Novel Poly(MMA-co-GMA)/Ag Nanocomposites for Biomedical Applications

et al. 2019

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T HE current work aims at preparation of novel nanocomposite materials based on polymerization of methyl methacrylate (MMA), glycidyl methacrylate (GMA), monomers and silver nanoparticles (Ag-NPs) for biomedical applications. The fabricated poly(MMA-co-GMA)/Ag nanocomposites were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), and FT-IR spectroscopy. The XRD and FT-IR spectra results confirmed the formation of the poly(MMA-co-GMA)/Ag nanocomposites with silver in nanoform. Furthermore, SEM indicated that the Ag-NPs had well dispersion in polymer matrix. Moreover, the prepared nanocomposites were displayed good enhancement in the thermal stability after addition of (Ag-NPs) by different ratios during polymerization process. Additionally, the antimicrobial activity of the synthesized poly(MMA-co-GMA)/Ag nanocomposites against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger as representatives for gram positive, gram negative bacteria, yeast and fungi were investigated. Thus, poly(MMA-co-GMA)/Ag nanocomposites were concluded as good candidates for biomedical applications.

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Influences of Ag-NPs doping chitosan/calcium silicate nanocomposites for optical and antibacterial activity

Cited by 80 publications

References 42 publications

Nanomaterials for alternative antibacterial therapy

Nanomaterials for alternative antibacterial therapy

Enhanced mechanical, thermal, and UV-shielding properties of poly(vinyl alcohol)/metal–organic framework nanocomposites

Preparation and Characterization of Novel Poly(MMA-co-GMA)/Ag Nanocomposites for Biomedical Applications

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