Influences of Ag/Ag2S core shell nanowires on the osteogenic differentiation of MC3T3-E1 cells and on the growth inhibition of methicillin-resistant Staphylococcus aureus

Oh, Hyeon Seung; Mohan, Harshavardhan; Sathya, Pavithra Muthukumar; Kim, Gitae; Ha, Ga-Hyeon; Shin, Taeho

doi:10.1016/j.mtcomm.2022.105194

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Tang et al showed that the formulated zinc oxide nanoparticles have possessed the notable bone regenerative activity through the enhancement of cell proliferation, differentiation, and calcium deposition in the human osteoblast-like cells [ 48 ]. In another study, silver-core shell nanowires were found to be effective in enhancing the differentiation of osteoblasts induced by reduced oxygen species by regulating the key marker genes runx2, osteoix, and osteocalcin [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of copper oxide nanoparticles and light-emitting diode irradiation on the cell viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla

Karkehabadi¹,

Rahmati²,

Abbasi³

et al. 2023

BMC Oral Health

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Objectives This experimental study aimed to assess the effect of copper oxide nanoparticles (CuONPs) and light-emitting diode (LED) irradiation on the cell viability and osteogenic/odontogenic differentiation of human SCAPs. Methods After the culture of SCAPs, the effects of different concentrations of CuONPs on cell viability were evaluated by the methyl thiazolyl tetrazolium (MTT) assay after 24 and 48 h, and the optimal concentration was determined (n = 12). SCAPs were then divided into four groups based on the type of treatment: (I) no-treatment control group, (II) exposure to CuONPs, (III) LED irradiation (635 nm, 200 mW/cm2) for 30 s, and (IV) exposure to CuONPs combined with LED irradiation. CuONPs were synthesized by a green technique, which was based on reduction and simultaneous stability of copper ions by using the pomegranate peel extract. After treatments, the expression of osteogenic/odontogenic markers including dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP), alkaline phosphatase (ALP), and dentin matrix acidic phosphoprotein 1 (DMP1) was evaluated in all four groups using quantitative real-time polymerase chain reaction (PCR) (n = 16). Also, osteogenic differentiation of SCAPs was evaluated qualitatively by alizarin red staining (ARS) to assess the matrix mineralization (n = 4). SPSS version 18 was used for data evaluation. The Kruskal–Wallis and Mann–Whitney tests were used to compare the groups. Results Exposure to 1 µg/mL CuONPs resulted in maximum viability of SCAPs. Concentrations of CuONPs over 10 µg/mL significantly decreased the viability of SCAPs. Real-time PCR showed that the expression of DMP1, BSP, ALP, and DSPP in CuONPs + LED and LED groups was significantly higher than that in CuONPs and control groups at both 24 and 48 h (P < 0.05). The density of ARS increased in all experimental groups after 24 h, and in CuONPs + LED and CuONPs groups after 48 h, compared to the control group. Conclusion Addition of CuONPs and LED irradiation of SCAPs in the culture medium significantly enhanced their osteogenic/odontogenic differentiation.

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Section: Discussionmentioning

confidence: 99%

Effect of copper oxide nanoparticles and light-emitting diode irradiation on the cell viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla

Karkehabadi¹,

Rahmati²,

Abbasi³

et al. 2023

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…[31] The instances of S. aureus infections including food poisoning, bacteremia, endocarditis, osteomyelitis and pneumonia have been reported. [32] The advent of multi-drug resistance in S. aureus has made it a difficult task to combat the bacterial infection with the standard antibiotics, therefore there lies the need to develop drugs as anti-bacterial agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Singh,

Thakur,

Priyanka

et al. 2024

ChemistrySelect

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Chromium is known to play an important role in various metabolic pathways; however, its excessive use can result in negative impact on mankind, this necessitates the development of sensors for Cr(III) ion. The current study has incorporated the synthesis of ether derived Schiff base allied silanes 4 a–4 d, which have been characterized using 1H NMR, 13C NMR and mass spectrometry. The spectroscopic technique of UV‐visible has been utilized to study the sensing behaviour of probe 4 a, resulting in a good sensing ability towards Cr(III) ion, yielding a detection limit of 4.2×10−7 M and an association constant value of 2.25×106 M−1. In order to study the stoichiometric binding between probe and metal ion, Job's plot method has been employed which shows 1 : 1 binding ratio. The mechanism of binding has been studied via 1H NMR, UV‐visible, FT‐IR spectroscopy and mass spectrometry. The binding has been further supported by DFT. The real sample analysis has been performed to validate the utility of the synthesized sensor in practical applications. The theoretical tool of molecular docking has been considered to study the protein‐ligand interaction between S. aureus bacterial protein and ligand 4 a, yielding a value of −7.63 kcal/mol for binding energy.

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Enhanced health benefits of Psidium guajava peel fermented with Lactiplantibacillus from Myeolchi-jeot: Antioxidant, anti-inflammatory, and anti-cancer properties

Mohan,

Muthukumar Sathya,

Lee

et al. 2024

Food Bioscience

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Influences of Ag/Ag2S core shell nanowires on the osteogenic differentiation of MC3T3-E1 cells and on the growth inhibition of methicillin-resistant Staphylococcus aureus

Cited by 3 publications

References 51 publications

Effect of copper oxide nanoparticles and light-emitting diode irradiation on the cell viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla

Effect of copper oxide nanoparticles and light-emitting diode irradiation on the cell viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Enhanced health benefits of Psidium guajava peel fermented with Lactiplantibacillus from Myeolchi-jeot: Antioxidant, anti-inflammatory, and anti-cancer properties

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