Influence on Therapeutic Decision Making of SPECT-CT for Different Regions of the Foot and Ankle

Claaßen, Leif; Uden, Theodor; Ettinger, Max; Daniilidis, Kiriakos; Stukenborg-Colsman, Christina; Plaaß, Christian

doi:10.1155/2014/927576

Cited by 27 publications

(24 citation statements)

References 13 publications

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“…The improvement in patients was clinically demonstrated by the efficacy of hESC therapy in treating LD patients, this was assessed by evaluating the change in SPECT scan at the end of treatment. [16][17][18]…”

Section: Materials and Methods Casesmentioning

confidence: 99%

Single-photon emission tomography imaging in patients with Lyme disease treated with human embryonic stem cells

Shroff¹

2018

Neuroradiol J

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Aim The purpose of this study was to evaluate the longitudinal changes in brain perfusion in patients with Lyme disease treated with human embryonic stem cells. Material and methods The study included 59 (age range 41.68 ± 16.37 years) patients with Lyme disease whose single-photon emission tomography imaging was performed before and after the human embryonic stem cell therapy. Technetium-hexa methyl propylene aminoxime single-photon emission tomography imaging was used to assess the hypoperfused lesions/regions in the brain prior to the therapy, as well as the improvement in perfusion after human embryonic stem cell treatment. Results After receiving human embryonic stem cell therapy, single-photon emission tomography imaging reflects a significant (>60%) improvement in 43 patients along with moderate (30-60%) and mild (<30%) improvement in 12 and four patients, respectively. The cerebral perfusion flow improved and the degree of hypoperfusion in the other regions significantly decreased after the human embryonic stem cell therapy. Interpretation of single-photon emission tomography imaging of brain images (before and after therapy) clearly presented the changes in color at various brain regions which represent the improvements in patients. Conclusion Single-photon emission tomography imaging could be used as a potential diagnostic tool to assess the response of Lyme disease patients to human embryonic stem cell therapy.

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Section: Materials and Methods Casesmentioning

confidence: 99%

Single-photon emission tomography imaging in patients with Lyme disease treated with human embryonic stem cells

Shroff¹

2018

Neuroradiol J

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“…This coregistration imaging modality has evolving and expanding indications in the foot and ankle . It has been useful in evaluating degenerative joints in the ankle and midfoot, painful total ankle replacements, malalignment, osteochondral lesions, diabetic foot infection, accessory bones, stress fractures, tarsal coalitions, and impingement and soft tissue pathology …”

Section: Discussionmentioning

confidence: 99%

The utility of the ankle SPECT/CT scan to predict functional and clinical outcomes in supramalleolar osteotomy patients

Gross

Barfield

Schweizer

et al. 2018

Journal Orthopaedic Research

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Combined single-photon emission computed tomography and conventional computed tomography (SPECT/CT) is a hybrid imaging modality that shows a combination of metabolic and structural information about the ankle, including arthritis. We hypothesize that uptake in specific locations within the ankle joint can be associated with both clinical outcomes and may help predict which patients will have a successful SMO. Eighty-five pre-operative SMO patients with varus (37), valgus (41), or neutral (7) alignment of the hindfoot were assessed using SPECT/CT. The level of activation on SPECT/CT scans was measured. Pre and Post-operative functional scores were recorded. Patients with medial gutter activation had significantly worse (p < 0.05) AOFAS alignment (AOFAS-A) scores pre-operatively. Patients with varus or valgus alignment did not have any difference in VAS pain scores, but those in valgus did have worse AOFAS-P (pain) scores. Those with cystic lesions had a worse FAOS score pre-operatively. Ten patients (12.5%) had a treatment failure. Pre or post-operative alignment did not correlate to a treatment failure. The only statistically significant (p = 0.036) poor prognostic indicator was a bipolar lesion. Pre-operative SPECT/CT evaluation of an ankle before a SMO can be used to clinically correlate patient-specific factors such as pain and function in the pre and post-operative period. We caution against performing a SMO in patients with bipolar activation on a pre-operative SPECT-CT scan. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2015-2021, 2018.

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“…[67891011121617] Mohan et al . reported that SPECT/CT influenced management in 10/19 (53%) patients in whom follow-up data were available.…”

Section: Added Value Of Single-photon Emission Computed Tomography/comentioning

confidence: 99%

Technetium-99m methylene diphosphonate single-photon emission computed tomography/computed tomography of the foot and ankle

Upadhyay

Beadsmoore

et al. 2017

World J Nucl Med

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The complex anatomy and function of the foot and ankle can make it difficult to determine the cause of symptoms in patients with foot and ankle pathology. Following initial clinical and radiographic assessment, additional imaging with magnetic resonance imaging may be required, which is often seen as the modality of choice. Although sensitive to pathological changes in bone metabolism and vascularity, technetium-99m (Tc-99m) bone scintigraphy often lacks the specificity and resolution required to evaluate the structures of the foot and ankle. Tc-99m methylene diphosphonate single-photon emission computed tomography/computed tomography (SPECT/CT) combines this sensitivity with the superior anatomical detail of CT, enabling better localization of pathological uptake and evaluation of associated structural changes. As a result, SPECT/CT has been growing in popularity for the assessment of patients with foot and ankle pathology where it can provide additional information that may change the initial diagnosis and subsequent management plan. Studies have reported modification of the surgical approach and site of intra-articular local anesthetic injections following SPECT/CT with good results. Interpretation of SPECT/CT studies requires an understanding of the pathological changes that result in increased tracer accumulation in addition to the CT changes that may be seen. This review aims to highlight the advantages of SPECT/CT, potential applications and explain the imaging appearances of common pathologies that may be observed.

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Influence on Therapeutic Decision Making of SPECT-CT for Different Regions of the Foot and Ankle

Cited by 27 publications

References 13 publications

Single-photon emission tomography imaging in patients with Lyme disease treated with human embryonic stem cells

Single-photon emission tomography imaging in patients with Lyme disease treated with human embryonic stem cells

The utility of the ankle SPECT/CT scan to predict functional and clinical outcomes in supramalleolar osteotomy patients

Technetium-99m methylene diphosphonate single-photon emission computed tomography/computed tomography of the foot and ankle

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