Influence on the Depth of Inhalation on the Effect of the &lt;i&gt;β&lt;/i&gt;2-Receptor-Stimulating Drug Fenoterol Hydrobromide (Berotec)

Vanderschueren, R. G. J. R. A.; Laros, C.D.; Swierenga, J

doi:10.1159/000194044

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…The amount of the aerosol dose reaching the lower respiratory tract can not be determined pharmacokinetically, but it is obvious that this amount is very low. This explains that clinical trials with nasal and buccal application of fenotcrol hydrobro mide gives effects comparable to aerosol ad ministration [37] to some extent.…”

Section: Site O F a Bsorptionmentioning

confidence: 96%

Absorption, Distribution and Excretion of the Tritium-Labelled β2 Stimulator Fenoterol Hydrobromide Following Aerosol Administration and Instillation into the Bronchial Tree

Laros¹,

Urk²,

Rominger³

1977

Respiration

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The administration by aerosol of fenoterol hydrobromide (Berotec®) was investigated in four test persons. Two patients with operable carcinomas of the lung were given tritium-labelled fenoterol hydrobromide aerosol immediately before undergoing surgery. Parts of the pulmonary segments removed were biochemically analysed and it was observed that the radioactive contents in pulmonary tissue and blood plasma were almost identical. The pharmacokinetic data recorded after aerosol administration, viz. plasma levels and renal excretion, are not different from those recorded after oral administration. The expired air following aerosol administration was examined in two patients, whereby less than 0.1 % of the dose administered was recovered. The oropharynx on the other hand, was found to contain 53 % of the dose immediately after administration. Absorption via the lungs was examined in four other test persons by instilling an aqueous solution of fenoterol hydrobromide into the right bronchial tree. Comparison of renal excretion levels showed that absorption here is greater than after oral administration; the plasma level curves, however, run a very similar course.

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Section: Site O F a Bsorptionmentioning

confidence: 96%