Influence on radiosensitivity of lung glandular cancer cells when ERCC1 gene silenced by targeted siRNA

Ren, Yulan; Lv, Xinquan

doi:10.1016/j.apjtm.2016.05.002

Cited by 1 publication

(2 citation statements)

References 19 publications

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“…The presence of the ERCC1 rs735482 genotype is associated with an increased risk of acute radiotoxicity in HNC 23 . Mechanistically, ERCC1 silencing by targeted siRNA was shown to increase the radiosensitivity of lung cancer cells 28 . Additionally, Keam et al showed that some variants in ERCC1 , XPD , and XRCC belonged to a single haplotype block 29 …”

Section: Discussionmentioning

confidence: 99%

“…23 Mechanistically, ERCC1 silencing by targeted siRNA was shown to increase the radiosensitivity of lung cancer cells. 28 Additionally, Keam et al showed that some variants in ERCC1, XPD, and XRCC belonged to a single haplotype block. 29 Cisplatin-based chemotherapy generates intra-and inter-strand cross-links that are repaired by nucleotide excision repair pathway; consequently, mutations in NER genes, including ERCC1, lead to hypersensitivity to cisplatin in cultured cells.…”

Section: Discussionmentioning

confidence: 99%

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Extreme acute radiation‐induced toxicity in a patient with polymorphous low‐grade adenocarcinoma of the nasopharynx and rare variants in DNA repair genes

Nowicka,

Kuna,

Stawiski

et al. 2023

Head & Neck

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BackgroundPolymorphous low‐grade adenocarcinoma (PLGA) is an extremely rare finding in the nasopharynx. There are no guidelines for the treatment of PLGA in this localization. Radiotherapy may be administered to treat this malignancy; however, in radiosensitive individuals, it is associated with a risk of severe radiotherapy‐induced toxicity.MethodsWe present a case of a 73‐year‐old woman with locally advanced polymorphous low‐grade adenocarcinoma of the nasopharynx who developed a severe adverse acute reaction to radiotherapy leading to treatment discontinuation. Despite intensive treatment, the patient died 40 days after RT initiation. Whole genome sequencing was performed using DNA from peripheral blood mononuclear cells in the search for variants that could explain such extreme toxicity.ResultsWe identified a combination of pathogenic variants that may have contributed to the patient's reaction to radiation therapy, including predisposing variants in XRCC1, XRCC3, and LIG4. We also identified candidate variants, not previously described in this context, which could be associated with radiation toxicity based on plausible mechanisms. We discuss previous reports of this rare tumor from the literature and known contributors to radiation‐induced toxicity.ConclusionsGenetic causes should be considered in cases of extreme radiosensitivity, especially when is not explained by clinical factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extreme acute radiation‐induced toxicity in a patient with polymorphous low‐grade adenocarcinoma of the nasopharynx and rare variants in DNA repair genes

Nowicka,

Kuna,

Stawiski

et al. 2023

Head & Neck

View full text Add to dashboard Cite

show abstract

Influence on radiosensitivity of lung glandular cancer cells when ERCC1 gene silenced by targeted siRNA

Abstract: The radiation sensitivity of lung glandular tumor could be improved after the ERCC1 gene was silenced by siRNA.

Cited by 1 publication

References 19 publications

Extreme acute radiation‐induced toxicity in a patient with polymorphous low‐grade adenocarcinoma of the nasopharynx and rare variants in DNA repair genes

Extreme acute radiation‐induced toxicity in a patient with polymorphous low‐grade adenocarcinoma of the nasopharynx and rare variants in DNA repair genes

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