Influence of β-Carotene Nanoemulsions on Technological Parameters and Stability in Food Matrices

Borba, Carina Molins; Araújo, Gabriela de Moraes Soares; Contessa, Camila Ramão; Dora, Cristiana Lima; Burkert, Janaína Fernandes de Medeiros

doi:10.1007/s11947-023-03060-x

Cited by 6 publications

(2 citation statements)

References 58 publications

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“…For 4-nBR-NE, viscosity control is crucial for stability and effectiveness in different applications [18][19][20]. In the food and pharmaceutical industries, an appropriate viscosity can ensure uniform dispersion and stability of products, improving product quality [21][22][23]. Surfactants play a key role in the preparation of NEs, helping to disperse hydrophobic substances in the water phase and contributing to the better formation of NEs.…”

Section: -N-butylresorcinolmentioning

confidence: 99%

Preparation and characterization of different supported 4-n-butylresorcinol nanoemulsions

Li,

Shao,

Ren

et al. 2024

Preprint

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4-n-butylresorcinol (4-nBR) has a significant effect on skin pigmentation, but its poor solubility, low stability and strong irritation to the skin limit its application. In this study, 4-nBR was prepared into 4-n-butylresorcinol nanoemulsion (4-nBR-NE) for the first time, which improved the solubility and stability of 4-nBR and greatly reduced the irritation of 4-nBR on skin. On this basis, the relationship between the viscosity of nanoemulsion and the formulation process, and the relationship between the ratio of surfactant and the formability of 4-nBR-NE were further studied. A nanoemulsion with adjustable viscosity (AV-NE) and nanoemulsion with low surfactant content has been successfully developed. The particle size of 4-nBR-NE was 13.34 ± 0.1646 nm, and PDI (0.08532 ± 0.0191) was small, and the particle size distribution was uniform. The encapsulation rate of 4-nBR-NE was 80.05 ± 0.75% by UV-VIS spectrophotometry. In addition, 4-nBR-NE had excellent stability for several months that the particle size was almost unchanged. We also confirmed through cells and transdermal evaluations that the original irritation of 4-nBR on cells and skin could be effectively reduced after preparation of 4-nBR-NE. Then 4-nBR-NE was prepared into essence. TEM showed that the shape of the 4-nBR-NE could still be observed after the essence was prepared, indicating that the shape of the 4-nBR-NE could still be maintained when the 4-nBR-NE was added to other products as an intermediate. In summary, 4-nBR-NE could not only improve the stability, solubility and transdermal delivery efficiency of 4-nBR, but also effectively reduce the original irritation of 4-nBR, which can be used to help treat pigmentation, melasma, freckles and other skin diseases. 4-nBR has increased its applicability in the pharmaceutical and cosmetic industries.

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Section: -N-butylresorcinolmentioning

confidence: 99%

Preparation and characterization of different supported 4-n-butylresorcinol nanoemulsions

Li,

Shao,

Ren

et al. 2024

Preprint

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“…They also play a crucial role in immune function, and their presence is closely linked to oxidative stress and inflammatory responses in the body . Among carotenoids, β-carotene has garnered considerable attention due to its numerous exceptional bioactivities . It serves as a safe provitamin A, boosting immunity and maintaining intestinal health, and exhibits physiological functions such as antioxidant and pro-oxidant properties, anticarcinogenicity, promotion of reproductive processes, and treatment of chronic diseases. , Nevertheless, β-carotene, being an insoluble compound with a high melting point, is susceptible to oxidation, isomerization, or degradation when exposed to light, temperature, and oxygen, resulting in a reduction in its biological activity.…”

Section: Introductionmentioning

confidence: 99%

Lipase-Responsive Lignin Composite Nanoparticles for the Delivery of Insoluble Bioactives

Bai,

Liu,

et al. 2024

Langmuir

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Low solubility and chemical instability are the main problems with insoluble bioactives. Lignin, with its exceptional biological properties and amphiphilicity, holds promise as a delivery system material. In this study, glycerol esters were incorporated into alkali lignin (AL) through ether and ester bonds, resulting in the successful synthesis of three hydrophobically modified alkali lignins (AL-OA, AL-OGL, and AL-SAN-OGL). Subsequently, lignin composite nanoparticles (LNPs@BC) encapsulating β-carotene were prepared using antisolvent and sonication techniques. The encapsulation rates were determined to be 37.69 ± 2.21%, 84.01 ± 5.55%, 83.82 ± 5.23%, and 83.11 ± 5.85% for LNP@BC-1, LNP@BC-2, LNP@BC-3, and LNP@BC-4, respectively, with AL, AL-OA, AL-OGL, and AL-SAN-OGL serving as the wall materials under optimized preparation conditions. The antioxidant properties and UV-absorbing capacity of the four lignins were characterized, demonstrating their efficacy in enhancing the oxygen and photostability of β-carotene. Following 6 h of UV irradiation, LNP@BC-4 exhibited a retention rate of 83.03 ± 2.85% for β-carotene, while storage under light-protected conditions at 25 °C for 7 days retained 73.33 ± 7.62% of β-carotene. Furthermore, the encapsulated β-carotene demonstrated enhanced thermal and storage stability. In vitro release experiments revealed superior stability of LNPs@BC in simulated gastric fluid (SGF), with β-carotene retention exceeding 77% in both LNP@BC-3 and LNP@BC-4. LNP@BC-4 exhibited the highest bioaccessibility in simulated intestinal fluid (SIF) at 46.96 ± 0.80%, that LNP@BC-1 only achieved 10.87 ± 0.90%. The enzymatic responsiveness of AL-OGL and AL-SAN-OGL was confirmed. Moreover, LNPs@BC exhibited no cytotoxicity toward L929 cells and demonstrated excellent hemocompatibility. In summary, this study introduces a novel enzyme-responsive modified lignin that has promising applications in the fields of food, biomedicine, and animal feed.

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Evaluation of Light-Emitting Diodes Applied to Rhodotorula mucilaginosa to Produce Carotenoids and Lipids

Rodrigues,

Contessa,

Burkert

et al. 2024

Food Bioprocess Technol

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Influence of β-Carotene Nanoemulsions on Technological Parameters and Stability in Food Matrices

Cited by 6 publications

References 58 publications

Preparation and characterization of different supported 4-n-butylresorcinol nanoemulsions

Preparation and characterization of different supported 4-n-butylresorcinol nanoemulsions

Lipase-Responsive Lignin Composite Nanoparticles for the Delivery of Insoluble Bioactives

Evaluation of Light-Emitting Diodes Applied to Rhodotorula mucilaginosa to Produce Carotenoids and Lipids

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