Influence of β-Amyloid Plaques on the Local Network Activity in the APP/PS1 Mouse Model of Alzheimer’s Disease

Cortical Activity and Rhythmic Patterns in Mouse Models of Aging and Alzheimer’s Disease

“…We found a slowing of the slow oscillation frequency with respect to their controls in both SAMP8 and 3xTg-AD mice while aging [93,98] (Figures 4 and 5, respectively), suggesting a reduction of network excitability due to genotype. Interestingly, and in contrast with previous observations, we observed systematic reductions in neuronal firing rates during Up and Down states near amyloid plaques in APP/PS1 mice [94] (Figure 3). In that study, we identified recordings obtained within 18 µm of an Aβ plaque and compared them with those obtained close to Aβ plaques and those obtained further away from them.…”

“…Moreover, deregulation of the Up-Down cycle featuring slow oscillations was observed, supporting the desynchronization of the cortical network. Further evidence of alterations in the gamma rhythm is provided in our characterization of the APP/PS1 mouse model [94], where lower activity synchronization in the beta-gamma frequency range (15-90 Hz) is shown ( Figure 3). The novelty of this work was that we analyzed excitability and cortical synchrony in the beta-gamma range in the proximity of the amyloid-β (Aβ) plaques ( Figure 3A), which was reduced close to the plaques.…”