Influence of weight status on bone mineral content measured by DXA in children

Sánchez-Ferrer, Francisco; Castell, Ernesto Cortés; Marco, Francisco Carratalá; Ruíz, Mercedes Juste; Rico, José Antonio Quesada; Nso-Roca, Ana Pilar

doi:10.1186/s12887-021-02665-5

Cited by 17 publications

(14 citation statements)

References 37 publications

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“…Furthermore, a Polish study investigating the prevalence of postural defects among children and adolescents with excessive body weight found that 69.2% of overweight individuals and 78.6% of individuals with obesity presented postural defects, of which valgus knees and flat feet were the most common [ 208 ]. Ferrer et al demonstrated in their study involving 553 children that body weight has an impact on bone mineralization [ 209 ]. The bone mineral content (BMC) and bone mineral density (BMD) measured by bone densitometry (DXA) were highest among those of normal weight and, interestingly, also among those who were overweight [ 209 ].…”

Section: Non-metabolic Complications Of Obesity In Childrenmentioning

confidence: 99%

“…Ferrer et al demonstrated in their study involving 553 children that body weight has an impact on bone mineralization [ 209 ]. The bone mineral content (BMC) and bone mineral density (BMD) measured by bone densitometry (DXA) were highest among those of normal weight and, interestingly, also among those who were overweight [ 209 ]. On the other hand, those subjects who were obese or very obese as well as those who were underweight showed lower BMC and BMD values [ 209 ].…”

Section: Non-metabolic Complications Of Obesity In Childrenmentioning

confidence: 99%

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Not Only Metabolic Complications of Childhood Obesity

Ciężki,

Odyjewska,

Bossowski

et al. 2024

Nutrients

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The increasing incidence of obesity in the pediatric population requires attention to its serious complications. It turns out that in addition to typical, well-known metabolic complications, obesity as a systemic disease carries the risk of equally serious, although less obvious, non-metabolic complications, such as cardiovascular diseases, polycystic ovary syndrome, chronic kidney disease, asthma, thyroid dysfunction, immunologic and dermatologic conditions, and mental health problems. They can affect almost all systems of the young body and also leave their mark in adulthood. In addition, obesity also contributes to the exacerbation of existing childhood diseases. As a result, children suffering from obesity may have a reduced quality of life, both physically and mentally, and their life expectancy may be shortened. It also turns out that, in the case of obese pregnant girls, the complications of obesity may also affect their unborn children. Therefore, it is extremely important to take all necessary actions to prevent the growing epidemic of obesity in the pediatric population, as well as to treat existing complications of obesity and detect them at an early stage. In summary, physicians treating a child with a systemic disease such as obesity must adopt a holistic approach to treatment.

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Section: Non-metabolic Complications Of Obesity In Childrenmentioning

confidence: 99%

Section: Non-metabolic Complications Of Obesity In Childrenmentioning

confidence: 99%

Not Only Metabolic Complications of Childhood Obesity

Ciężki,

Odyjewska,

Bossowski

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…In addition, constitutive MetS components, mainly attributable to obesity, have been suggested to be potential predictors of bone health. Although many studies have demonstrated a higher BMD and reduced risk of fractures in obese individuals in comparison to controls [9][10][11] or an inverted U-shaped relationship between BMI and BMD [12], it is generally believed that the reduced bone mass and increased fracture rates are associated much more with the level of adiposity and/or excessive visceral distribution of fat mass than with the surrogate measures of obesity, such as BMI or waist circumference (WC) [10,13,14]. Kim et al found that high-density lipoprotein cholesterol (HDL-C) levels in serum are positively associated with trochanteric BMD; however, HDL-C levels were significantly lower in the control group than in the group with fractures [13].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis

et al. 2023

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Studies to date have yielded conflicting results on associations between components of metabolic syndrome (MetS) and bone mineral density (BMD), particularly in men. This current systematic review and meta-analysis addresses the existing gap in the literature and aims to evaluate bone mineral density (BMD) at the femoral neck (FN) and lumbar spine (LS) in men diagnosed with MetS. The two study authors independently searched PubMed, Cinahl, Embase, and Web of Science up to 8 February 2022 for studies in English. The inclusion criteria were (i) diagnosis of MetS according to the NCEP-ATP III 2001 criteria; (ii) adult male demographic; (iii) analyzable data on BMD in at least two sites using dual-energy X-ray absorptiometry (DXA), and (iv) original observational studies. Case reports and non-English articles were excluded. We analyzed the results of seven studies providing data on bone density in men with MetS. Results: Based on random effect weights, the mean BMD of the femoral neck and lumbar spine were 0.84 and 1.02, respectively. The mean lumbar spine T-score was −0.92. In meta-regression analysis, the variances in mean BMD in the lumbar spine and femoral neck could not be significantly explained by BMI (lumbar BMD: Q = 1.10, df = 1, p = 0.29; femoral neck BMD: Q = 0.91, df = 1, p = 0.34). Our meta-analysis suggests normal bone mass in adult males with MetS. Due to the high heterogeneity in the seven analyzed studies and the lack of control groups in these studies, further research is needed to fully elucidate the associations between MetS and its components and BMD in men.

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“…A systematic review with meta-analysis showed that overweight and obese children had significantly higher BMD than normal weight children [7]. However, it has also been noted that the bone mass of obese children and adolescents is insufficient for their body weight [8,9] and that BMD is lower in adolescents with obesity [10]. During growth, lean mass has been directly related to BMD variability [11][12][13][14], while the effect of fat mass on BMD remains controversial [13].…”

Section: Introductionmentioning

confidence: 99%

Bone mineral density and body composition in normal weight, overweight and obese children

et al. 2022

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Background There is a possibility that excess body fat affects bone mass gain and may compromise skeletal health in obese children. The purpose of the study was to identify the relationship between bone mineral density (BMD) and body composition in normal weight, overweight and obese children. Methods This was a cross-sectional study of 6- to 11-year-old children who attended the hospital's outpatient clinic. They were apparently healthy and had no history of prematurity, low birth weight, or chronic diseases. Body mass index (BMI) was used to identify subjects as normal weight, overweight or obese. BMD and body composition were assessed by dual energy X–ray absorptiometry. The BMD values (total and lumbar spine) were compared between normal weight, overweight and obese children. Correlation coefficients were calculated, and multivariate models were performed. Results Forty-nine children were included: 16 with normal weight, 15 that were overweight and 18 with obesity; the mean age was 8.4 ± 1.7 years. All the participants had a normal BMD (> – 2 SD). BMD was higher in obese children and had a positive correlation with total and trunk lean mass in the three study groups (p < 0.001). In obese children, an inverse correlation of lumbar spine BMD (Z score) with total and trunk fat mass (p < 0.05) was identified. In the multivariate models (with the whole group), the total lean mass was the only significant variable that explained BMD variability. Conclusions BMD in obese children was higher than that in normal weight children, which is explained by their greater lean mass and not by excess body fat. In obese children, a higher fat mass was related to a lower lumbar spine BMD. Lean mass had a direct correlation with BMD in the three study groups and was the most important predictor of BMD, reflecting the importance of strengthening the muscular system through performing physical activity and practicing a healthy lifestyle.

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Influence of weight status on bone mineral content measured by DXA in children

Cited by 17 publications

References 37 publications

Not Only Metabolic Complications of Childhood Obesity

Not Only Metabolic Complications of Childhood Obesity

The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis

Bone mineral density and body composition in normal weight, overweight and obese children

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