Influence of water-soluble flavonoids, quercetin-5′-sulfonic acid sodium salt and morin-5′-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model

Abstract

, et al.. Influence of water-soluble flavonoids: Quercetin5'-sulfonic acid sodium salt and morin-5'-sulfonic acid sodium salt on antioxidant parameters in the subacute cadmium intoxication mouse model. Experimental and Toxicologic Pathology, Elsevier, 2010, 62 (2) Cite this article as: Ewa Chlebda, Jan Magdalan, Anna Merwid-La Rd, Małgorzata Trocha, Maria Kopacz, Anna Kuźniar, Dorota Nowak and Adam Szela R g, Influence of water-soluble flavonoids: Quercetin-5'-sulfonic acid sodium salt and morin-5'-sulfonic acid sodium salt on antioxidant parameters in the subacute cadmium intoxication mouse model, Experimental and Toxicologic Pathology (2009), doi:10.1016/j.etp.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Water-soluble quercetin-5'-sulfonic acid sodium salt (NaQSA) and morin-5'-sulfonic acid sodium salt (NaMSA) could exert an antagonistic effect on cadmium intoxication. The aim of the study was to examine the influence of these substances on superoxide dismutase (SOD) and glutathione (GSH) levels in the mouse liver in the subacute cadmium intoxication model. NaQSA and NaMSA signicificantly counteracted cadmium-induced decreases in SOD and GSH levels. No significant differences in SOD and GSH levels between groups exposed to cadmium receiving NaQSA or/and NaMSA were observed.

New sulfonic derivatives of quercetin as complexing reagents: synthesis, spectral, and thermal characterization

“…Furthermore, NaQSA and NaMSA, due to the ability to chelate metals ions, have been applied in the studies on detoxification of mercury, cadmium, and lead in rats [11][12][13]. It is worth emphasizing that NaQSA and NaMSA exert low toxicity.…”

Effects of morin-5′-sulfonic acid sodium salt (NaMSA) on cyclophosphamide-induced changes in oxido-redox state in rat liver and kidney

“…Similar effect of NaMSA administration on decreased GSH level in mice liver was observed in subacute cadmium poisoning described in our previous work. 18 Moreover, in earlier experiment of Ray et al 30 antioxidant action of naturally occurring morin was revealed in CPX/ flutamide-induced lipid peroxidation. Flavonoid constituents of citrus extract (Citrus aurantium var.…”

“…Such action of NaMSA is difficult to explain, because natural flavonoids as well as their synthetic derivatives are considered as antioxidative compounds. 12,17,18 In our earlier work, NaMSA given alone did not influence oxido-redox state parameters in mice but reversed unfavorable changes in LPOs level caused by subacute cadmium intoxication. 17 Single reports also indicated antiperoxidative potential of morin on CPX/flutamide-induced lipid peroxidation in rabbits confirmed by MDA level.…”

Effects of Cadmium and Monensin on Spleen of Mice, Subjected to Subacute Cadmium Intoxication

“…Different compounds were tested in animal models as antagonists of Cd, but information regarding their effects on Cd-induced alterations in spleen function is still sparse (Blanuša et al, 2005;Nemmiche et al, 2007;Luchese at al., 2007;Gong at al., 2008;Shukla and Kumar, 2009;Manna et al, 2009;Fouad at al., 2009;Sinha et al, 2009;Flora and Pachauri, 2010;Chlebda et al, 2010;Saljooghi and Fatemi, 2010;Sinicropi et al, 2010). Our recent studies demonstrated that monensin (a polyether…”