Influence of water-soluble derivatives of [60]fullerene on therapeutically important targets related to neurodegenerative diseases

Kotelnikova, R. A.; Smolina, A. V.; Grigoryev, V. V.; Faingold, I. I.; Мищенко, Д. В.; Rybkin, A. Yu.; Poletayeva, D. A.; Van'kin, G. I.; Zamoyskiy, V. L.; Voronov, Ilya I.; Troshin, Pavel A.; Котельников, А. И.; Бачурин, С. О.

doi:10.1039/c4md00194j

Cited by 20 publications

(5 citation statements)

References 37 publications

(34 reference statements)

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“…The neuroprotective activity of fullerene derivatives may not be ignored either. Encouraging results of their use for the treatment of neurodegenerative pathologies (Alzheimer's and Parkinson's diseases and other diseases accompanied by cognitive impairment) leading to dementia have been demonstrated [ 39 – 40 ]. Moreover, it is noted that the almost nonexistent toxicity of the C 60 derivatives allows to use them in living systems without negative consequences.…”

Section: Introductionmentioning

confidence: 99%

[2 + 1] Cycloaddition reactions of fullerene C₆₀ based on diazo compounds

Biglova¹

2021

Beilstein J. Org. Chem.

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The most common variant of fullerene core functionalization is the [2 + 1] cycloaddition process. Of these, reactions leading to methanofullerenes are the most promising. They are synthesized in two main reactions: nucleophilic cyclopropanation according to the Bingel method and thermal addition of diazo compounds. This present review summarizes the material on the synthesis of monofunctionalized methanofullerenes – analogues of [60]PCBM – based on various diazo compounds. The main cyclopropanating agents for the synthesis of monosubstituted methanofullerenes, the optimal conditions and the mechanism of the [2 + 1] cycloaddition, as well as the practical application of the target products are analyzed.

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Section: Introductionmentioning

confidence: 99%

[2 + 1] Cycloaddition reactions of fullerene C₆₀ based on diazo compounds

Biglova¹

2021

Beilstein J. Org. Chem.

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“…The water-soluble, hydroxylated fullerene has several clinical applications, including use as a drug carrier to bypass blood ocular barriers, 31 also has been demonstrated to prevent NO-induced cytoskeletal depolymerization and nuclear damage, and to accelerate endothelial cell repair. 32,33 Moreover, neuroprotective activity of water-soluble fullerene derivatives has been reported; 34 nevertheless, we found that it was not able to enhance neuronal growth. The membrane materials chosen to build a given scaffold should exhibit multiple properties to support neuronal cell growth.…”

Section: Discussionmentioning

confidence: 63%

Polyelectrolyte membrane scaffold sustains growth of neuronal cells

Grzeczkowicz

Gruszczynska-Biegala

Czeredys

et al. 2019

J Biomedical Materials Res

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Cell immobilization within nano‐thin polymeric shells can provide an optimal concentration of biological material in a defined space and facilitate its directional growth. Herein, polyelectrolyte membrane scaffolds were constructed using a layer‐by‐layer approach to determine the possibility of promoting improved growth of rat cortical neuronal cells. Membrane presence was confirmed by Fourier transform infrared spectroscopy, Zeta potential, and atomic force and scanning electron microscopy. Scaffold performance toward neuronal cell growth was assessed in vitro during a 14‐day culture. Cell conditions were analyzed immunocytochemically. Furthermore, western blot and real‐time PCR analyses were used to validate the presence of neuronal and glial cells on the scaffolds. We observed that alginate/chitosan, alginate/polylysine, and polyethyleneimine/chitosan scaffolds promote neuronal growth similarly to the control, poly‐ d ‐lysine/laminin. We conclude that membranes maintaining cell viability, integrity and immobilization in systems supporting neuronal regeneration can be applied in neurological disease or wound healing treatment. © 2018 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 839–850, 2019.

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“…The effect of the selected constituents on MAO-B was explored by using the benzylamine deamination assay on 96-well plates. [ 25 ] A fixed substrate concentration and varying inhibitor concentrations (10–300 nM) were used to determine the higher half maximal inhibitory concentrations (IC 50 ) value at the point where 50% inhibition of the catalytic activity of the enzyme occurred. For MAO-B, the substrate concentration of 10 mM benzylamine was chosen.…”

Section: Methodsmentioning

confidence: 99%

Kinetics of inhibition of monoamine oxidase using curcumin and ellagic acid

Khatri¹,

Juvekar²

2016

Phcog Mag

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Background:Curcumin and ellagic are the natural polyphenols having a wide range of pharmacological actions. They have been reported to have their use in various neurological disorders.Objective:This study was aimed to evaluate the effect of curcumin and ellagic acid on the activity of monoamine oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters which are pivotal for neuronal development and function.Materials and Methods:The in vitro effects of these selected polyphenols on MAO activities in mitochondria isolated from rat brains were examined. Brain mitochondria were assayed for MAO type-B (MAO-B) using benzylamine as substrates. Rat brain mitochondrial MAO preparation was used to study the kinetics of enzyme inhibition using double reciprocal Lineweaver–Burk plot.Results:MAO activity was inhibited by curcumin and ellagic acid; however, higher half maximal inhibitory concentrations of curcumin (500.46 nM) and ellagic acid (412.24 nM) were required compared to the known MAO-B inhibitor selegiline. It is observed that the curcumin and ellagic acid inhibit the MAO activity with both the competitive and noncompetitive type of inhibitions.Conclusions:Curcumin and ellagic acid can be considered a possible source of MAO inhibitor used in the treatment of Parkinson's and other neurological disorders.SUMMARY Monoamine oxidase (MAO) is involved in a variety of neurological disorders including Parkinson's disease (PD)Curcumin and ellagic acid inhibit the monoamine oxidase activityEllagic acid revealed more potent MAO type-B (MAO-B) inhibitory activity than curcuminKinetic studies of MAO inhibition using different concentrations of curcumin and ellagic acid were plotted as double reciprocal Lineweaver–Burk plotThe mode of inhibition of both compounds toward MAO-B is mixed (competitive and uncompetitive) type of inhibition with both the competitive and noncompetitive type of inhibitions. Abbreviations used: MAO: Monoamine oxidase, IC50: Higher half maximal inhibitory concentrations, PD: Parkinson's disease, LB: Lewy bodies, SNpc: Substantia nigra pars compacta, ROS: Reactive oxygen species, SG: Selegiline, DMC: demethoxycurcumin, BDMC: Bisdemethoxycurcumin.

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Influence of water-soluble derivatives of [60]fullerene on therapeutically important targets related to neurodegenerative diseases

Abstract: Water soluble fullerene derivatives I and II were shown to behave as promising neuroprotective agents that improve cognitive functioning in animals.

Cited by 20 publications

References 37 publications

[2 + 1] Cycloaddition reactions of fullerene C₆₀ based on diazo compounds

[2 + 1] Cycloaddition reactions of fullerene C₆₀ based on diazo compounds

Polyelectrolyte membrane scaffold sustains growth of neuronal cells

Kinetics of inhibition of monoamine oxidase using curcumin and ellagic acid

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Influence of water-soluble derivatives of [60]fullerene on therapeutically important targets related to neurodegenerative diseases

Abstract: Water soluble fullerene derivatives I and II were shown to behave as promising neuroprotective agents that improve cognitive functioning in animals.

Cited by 20 publications

References 37 publications

[2 + 1] Cycloaddition reactions of fullerene C60 based on diazo compounds

[2 + 1] Cycloaddition reactions of fullerene C60 based on diazo compounds

Polyelectrolyte membrane scaffold sustains growth of neuronal cells

Kinetics of inhibition of monoamine oxidase using curcumin and ellagic acid

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Product

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[2 + 1] Cycloaddition reactions of fullerene C₆₀ based on diazo compounds

[2 + 1] Cycloaddition reactions of fullerene C₆₀ based on diazo compounds