Influence of Water Hardness on Silver Ion and Silver Nanoparticle Fate and Toxicity Toward<i>Nitrosomonas europaea</i>

Anderson, James M.; Semprini, Lewis; Radniecki, Tyler S.

doi:10.1089/ees.2013.0426

Cited by 18 publications

(9 citation statements)

References 37 publications

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“…Particularly for metal and metal oxide NPs, dissolution processes have been recognized of being essential for the NPs' fate, biodistribution and also ROS-mediated toxicity (46,(85)(86)(87)(88)(89). Here, proteins play central roles not only by forming a protein corona, but also by binding released toxic metal (33,84) ions, as has been shown for silver NPs in both, physiological and environmental systems (86,90). Close inspection of the literature indeed reveals that the detailed fate of the original corona, as it travels through membranes and barriers, thereby interacting with the extracellular matrix and various cellular enzymatic machineries is still not resolved in detail, and may differ in various body organs, such as the liver or the brain.…”

Section: Factors Influencing Nm-corona Composition -Fate and -Toxicitymentioning

confidence: 99%

The bio-corona and its impact on nanomaterial toxicity

Westmeier

Chen²,

Stauber

et al. 2015

European Journal of Nanomedicine

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Abstract:The rapidly growing application of nanosized materials and nano-scaled processes will result in increased exposure of humans and the environment. The small size of nanomaterials (NM) comparable with molecular building blocks of cells raises concerns that their toxic potential cannot be extrapolated from studies of larger particles due to their unique physico-chemical properties. These properties are also responsible that NM rapidly adsorb various (bio)molecules when introduced into complex physiological or natural environments. As the thus formed protein/biomolecule 'corona' seems to affect the NM' in situ identity, an understanding of its toxicological relevance and the biophysical forces regulating corona formation is needed but not yet achieved. This review introduces our current concept of corona formation and evolution and present analytical methods for corona profiling. We discuss toxicity mechanisms potentially affected by the biomolecule corona, including NM cellular uptake and impact on components of the blood system. Further, we comment on pending knowledge gaps and challenges, which need to be resolved by the field. We conclude by presenting a tiered systems biology-driven approach recommended to mechanistically understand the coronas' nanotoxicological relevance and predictive potential.

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Section: Factors Influencing Nm-corona Composition -Fate and -Toxicitymentioning

confidence: 99%

The bio-corona and its impact on nanomaterial toxicity

Westmeier

Chen²,

Stauber

et al. 2015

European Journal of Nanomedicine

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“…Ammonia oxidizing bacteria (AOB) are more sensitive to Ag-NPs than nitrite oxidizing bacteria (NOB), ( Yang et al, 2013 , 2014a ). An elevated ammonia concentration can increase the toxicity of Ag-NPs ( Mumper et al, 2013 ), while greater water hardness decreases toxicity ( Yang et al, 2013 ; Anderson et al, 2014 ). At sublethal concentrations, Ag-NPs can upregulate amoA ( Yang et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of silver nanoparticles on intact wastewater biofilms

et al. 2015

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Silver nanoparticles (Ag-NPs) have strong antibacterial properties, which may adversely affect biological wastewater treatment processes. To determine the overall effect, intact biofilm samples were collected from the rotating biological contactor at the local wastewater treatment plant and treated with 200 mg Ag/L Ag-NPs for 24 h. The biofilm uptake of Ag-NPs was monitored with transmission electron microscopy. Forty-five minutes after Ag-NP application, Ag-NPs were seen in the biofilm extracellular polymeric substances (EPS). After 24 h, Ag-NPs had entered certain microbial cells, while other cells contained no observable Ag-NPs. Some cells were dying after the uptake of Ag-NPs. However, there was no significant reduction in cultivable bacteria in the biofilms, based on heterotrophic plate counts (HPC). While this may indicate that wastewater biofilms are highly resistant to Ag-NPs, the HPC represents only a small portion of the total microbial population. To further investigate the effects of Ag-NPs, a GeoChip microarray was used to directly detect changes in the functional gene structure of the microbial community in the biofilm. A clear decrease (34.6% decreases in gene number) in gene diversity was evident in the GeoChip analysis. However, the complete loss of any specific gene was rare. Most gene families present in both treated and untreated biofilms. However, this doesn’t necessarily mean that there was no change in these families. Signal intensity decreased in certain variants in each family while other variants increased to compensate the effects of Ag-NPs. The results indicate that Ag-NP treatment decreased microbial community diversity but did not significantly affect the microbial community function. This provides direct evidence for the functional redundancy of microbial community in engineered ecosystems such as wastewater biofilms.

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“…The maximum adsorption capacity is reached and a DBS bilayer occurs on the nanoparticle surface when the DBS concentration in aqueous phase is equal to or slightly higher than the CMC of DBS Koopal, 1992a, 1992b;Bitting and Harwell, 1987). Previous studies (Shih et al, 2012;Almusallam et al, 2012;Anderson et al, 2014) have shown the impacts of electrolytes on nanoparticle aggregation behaviors. In the mixed aqueous solution containing DBS and TiO 2 -NPs, addition of electrolytes like NaCl and CaCl 2 has a remarkable impact on the adsorption of DBS onto nanoparticles and thus the interactions among nanoparticles (Fig.…”

Section: Interaction Mechanisms Between Tio 2 -Nps and Dbsmentioning

confidence: 93%

“…When the pH of a nanoparticle suspension approaches the point of zero charge (PZC), the nanoparticles tend to aggregate rapidly due to low surface charge and low electrostatic repulsion (Zhu et al, 2014). The incorporation of counterion species can cause the shift of zeta potential toward a lower value, hence promoting the aggregation process greatly (Shih et al, 2012;Anderson et al, 2014). Basically, the aquatic organic matters in natural water include NOMs and anthropogenic organic compounds categorized by their sources.…”

Section: Introductionmentioning

confidence: 99%