Influence of Water and Sodium Diuresis and Furosemide on Urinary Excretion of Vitamin B&lt;sub&gt;6&lt;/sub&gt;, Oxalic Acid and Vitamin C in Chronic Renal Failure

Mydlík, M; Derzsiová, K; Zemberová, E

doi:10.1159/000057474

Cited by 26 publications

(10 citation statements)

References 7 publications

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“…Renal retention of ascorbate becomes less effective under pathological conditions. For instance, water diuresis increases urinary excretion of vitamin C in human subjects (25). Urinary excretion of ascorbate also increases in diabetic patients with microvascular disease and may cause the lowering of plasma ascor-bate concentration in these patients (38).…”

Section: Discussionmentioning

confidence: 99%

Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat

Armour

Tyml

Lidington

et al. 2001

Journal of Applied Physiology

121

147

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Septic patients have low plasma ascorbate concentrations and compromised microvascular perfusion. The purpose of the present experiments was to determine whether ascorbate improves capillary function in volume-resuscitated sepsis. Cecal ligation and perforation (CLP) was performed on male Sprague-Dawley rats. The concentration of ascorbate in plasma and urine, mean arterial blood pressure, and density of continuously perfused capillaries in the extensor digitorum longus muscle were measured 24 h after surgery. CLP caused a 50% decrease (from 56 +/- 4 to 29 +/- 2 microM) in plasma ascorbate concentration, 1,000% increase (from 46 +/- 13 to 450 +/- 93 microM) in urine ascorbate concentration, 20% decrease (from 115 +/- 2 to 91 +/- 2 mmHg) in mean arterial pressure, and 30% decrease (from 24 +/- 1 to 17 +/- 1 capillaries/mm) in the density of perfused capillaries, compared with time-matched controls. A bolus of intravenous ascorbate (7.6 mg/100 g body wt) administered immediately after the CLP procedure increased plasma ascorbate concentration and restored both blood pressure and density of perfused capillaries to control levels. In vitro experiments showed that ascorbate (100 microM) inhibited replication of bacteria and prevented hydrogen peroxide injury to cultured microvascular endothelial cells. These results indicate that ascorbate is lost in the urine during sepsis and that a bolus of ascorbate can prevent microvascular dysfunction in the skeletal muscle of septic animals. Our study supports the view that ascorbate may be beneficial for patients with septic syndrome.

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Section: Discussionmentioning

confidence: 99%

Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat

Armour

Tyml

Lidington

et al. 2001

Journal of Applied Physiology

121

147

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“…Furosemide increases urinary excretion of ascorbate [56], ascorbate clearance is increased in diabetic nephropathy in comparison to only microalbuminuric diabetes patients [57], and ascorbate is freely filtered and lost into the dialysate. Plasma levels are reduced by 33-50% during hemodialysis [40,41,49] or hemodiafiltration, mounting to an estimated loss of 200 mg/week [43].…”

Section: Ascorbate In Chronic Kidney Disease Patientsmentioning

confidence: 96%

Vitamin C in Chronic Kidney Disease and Hemodialysis Patients

Deicher

Hörl

2003

Kidney Blood Press Res

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Increments of oxidative stress have been addressed as one potential cause for the accelerated atherosclerosis of chronic kidney disease patients. Ascorbate represents one of the most prominent antioxidants both in plasma as well as intracellulary, exerting beneficial effects by an inhibition of lipid peroxidation and by reducing endothelial dysfunction. However, in the presence of transition metals like iron, ascorbate may give rise to an increased generation of oxidants, and ascorbylation may impose additional carbonyl stress to uremic patients. Unsupplemented dialysis patients have reportedly lower plasma levels of ascorbate in comparison to healthy controls, mostly due to a loss into the dialysate or, in case of not dialyzed patients, increased urinary losses. Currently, 60 mg of ascorbate are recommended for chronic kidney disease patients, and 1–1.5 g of oral ascorbate/week in case of suspected subclinical ascorbate deficiency or 300 mg parenteral ascorbate/dialysis session, respectively. Ascorbate’s role in modifying arterial blood pressure remains unclear, but anemic patients with functional iron deficiency might benefit from short-term, moderately dosed ascorbate supplements.

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“…The effect profiles of coffee on folate, PLP, and riboflavin could be explained if coffee consumption, through renal mechanisms, increases vitamin excretion at high blood vitamin concentrations. Reports describing increased excretion and lower blood concentrations of micronutrients (including folate, PLP and riboflavin) and higher tHcy in patients given diuretics (32)(33)(34)(35)(36) support this hypothesis. Caffeine has been shown not to modify the glomerular filtration rate (37 ), but it affects the proximal tubules where most of the vitamins are reabsorbed (37)(38)(39).…”

Section: Possible Mechanismsmentioning

confidence: 96%

Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

et al. 2008

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Background: Coffee consumption has been associated with several risk factors for coronary heart disease, including increased cholesterol, increased blood pressure, and increased plasma total homocysteine (tHcy). tHcy is determined by several B-vitamins. However, reports about the association between coffee intake and B-vitamin status are few. Methods: We measured plasma B-vitamins and tHcy in a cohort of 10 601 healthy, middle-aged Norwegian men and women. Information about lifestyle factors, including coffee consumption, smoking, alcohol use, height, and weight, was obtained by interview. Results: Coffee consumption was dose-dependently associated with reduced plasma B-vitamin concentrations. Compared with coffee abstainers, individuals drinking ≥4 cups/day had 11.7% (P < 0.001), 14.1% (P < 0.001), and 5.5% (P = 0.01) lower plasma concentrations of folate, pyridoxal phosphate, and riboflavin, respectively, and the mean tHcy concentration was 6.8% (P < 0.001) higher. Quantile regression analysis showed essentially no difference in B-vitamin concentrations between coffee consumption categories at low vitamin concentrations but a progressive increase in the difference at higher concentrations. This pattern of differences (effect profile) was found independently of smoking status, alcohol intake, and sex. The decrease in folate explained approximately half of the increase in tHcy. Conclusions: Coffee consumption was associated with reduced circulating B-vitamin concentrations. The observed effect profiles indicated that coffee consumption preferentially affected the upper, but not the lower, part of the B-vitamin concentration distributions. We hypothesize that coffee consumption may increase the loss of surplus B-vitamins by excretion in urine.

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Influence of Water and Sodium Diuresis and Furosemide on Urinary Excretion of Vitamin B<sub>6</sub>, Oxalic Acid and Vitamin C in Chronic Renal Failure

Cited by 26 publications

References 7 publications

Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat

Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat

Vitamin C in Chronic Kidney Disease and Hemodialysis Patients

Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

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