Influence of vitamin D in bone healing

Freitas, Rafaela Pignatti de; Nunes, Fernanda Parini; Santos, Lívia Marcela; Weckwerth, Paulo Henrique; Silveira, Elcia Maria; Gulinelli, Jéssica Lemos; Santos, Pâmela Letícia dos

doi:10.5935/2525-5711.20170014

Cited by 5 publications

(9 citation statements)

References 19 publications

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“…Also, some studies revealed adequate calcium/vitamin D is important to provide sufficient calcium for mineralization to prevent bone loss. [17][18][19][20][21][22] In this case report, complete healing and bone regeneration for horizontal bone defect around the implant which is observed by increase 3-4 mm bone height and 1-2 mm in bone thickness after one year of treatment. This is approving the effectiveness of nonsurgical treatment and LLLT in the treatment of peri-implantitis.…”

Section: Discussionmentioning

confidence: 61%

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Diode laser assisted horizontal bone defect regeneration in the treatment of peri‐implantitis

Habash

Jayash

2021

Clinical Case Reports

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Section: Discussionmentioning

confidence: 61%

“…The vitamin D has an anabolic effect on osteoblasts and can to increase bone growth and bone density. Also, some studies revealed adequate calcium/vitamin D is important to provide sufficient calcium for mineralization to prevent bone loss 17‐22 …”

Section: Discussionmentioning

confidence: 99%

Diode laser assisted horizontal bone defect regeneration in the treatment of peri‐implantitis

Habash

Jayash

2021

Clinical Case Reports

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“…Regardless, some of these studies have proven the vitamin D effect on the cellular process of bone healing. However, the exact mechanism of this influence has not yet been defined [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Time Until Full Weight Bearing After Hip Fractures and Vitamin D Levels in Patients Aged 50 Years and Above

Altuwairqi

Tammar

et al. 2022

Cureus

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Introduction Hip fractures are common in the elderly, especially with vitamin D deficiency. Currently, there is a paucity of case-control studies regarding the relationship between the time until full weight bearing of hip fractures and vitamin D levels in Saudi Arabia. Our aim is to determine time until full weight bearing of hip fractures in patients with vitamin D deficiency compared with normal vitamin D in the age of 50 and above. Materials and methods This was a hospital-based non-interventional retrospective case-control study conducted among patients with hip fractures aged 50 years and above between January 2017 and April 2021. It was done at King Abdulaziz university hospital, Jeddah, Saudi Arabia. A review of the medical records and operation records for the relative operation was done to check patients' lab values around the time of the operation and following the documented healing process. Data were analyzed using SPSS version 26 (IBM Inc., Armonk, New York). Correlation analysis was performed using Spearman's test, and a p-value of 0.05 was considered statistically significant. Results In our research, 36 patients were participants in the study, with about two-thirds (22) of the participants being female (61.1%). 52.8% of the participants had an age ranging from 71-80 years, with a mean age of 75.66 ± 9.53 years. A non-significant relationship between the time until full weight bearing of hip fractures and the vitamin d levels is demonstrated. By that, the research question was disproved by the given data. Conclusion The time until full weight bearing of hip fracture is not significantly related to vitamin D level. In this study, the majority of patients (77.1%) were vitamin D deficient, which raises our concern for vitamin D deficiency to be a major health problem in our society. However, this evidence should be further assessed in larger trials. Additional studies on this topic are recommended to be done.

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“…The vitamin D–parathyroid hormone axis (PTH-Vit D) plays an important role in maintaining bone mass density and calcium homeostasis ( 15 ). The active form of vitamin D, namely, 1,25 dihydroxycholecalciferol, regulates the absorption of calcium from the intestine ( 15 , 16 ). Studies have shown that a vitamin D deficiency slows down the healing of broken bones.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Waterpipe Tobacco Smoking on Bone Healing Following Femoral Fractures in Male Rats

et al. 2021

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Background: Given the increasing use of waterpipe tobacco smoking in the world and its unknown effects on bone healing, this study investigated the repairing of femoral bone fractures in rats exposed to waterpipe tobacco smoking (WTS).Main Methods: This study involved 40 male Wistar rats that were divided into two groups, including the femoral fracture (Fx) and the Fx + WTS groups. Each group was divided into two subgroups that were evaluated for bone healing 28 and 42 days after femoral fracture. After fixing the fractured femur, the healing process was evaluated by radiography, pathological indicators, and a measurement of the blood levels of vascular endothelial growth factor (VEGF), parathyroid hormone (PTH), Ca ++, transforming growth factor-beta (TGF-β), and insulin-like growth factor 1 (IGF-1). Additionally, the density of VEGF and CD34 in fracture tissue was investigated by immunohistochemistry.Key Findings: Radiographic findings showed that factors related to the earlier stages of bone healing had higher scores in the Fx + WTS28 and 42 subgroups in comparison to the Fx groups. The density of VEGF and CD34 showed that the angiogenesis processes were different in the bone fracture area and callus tissue in the Fx +WTS subgroups. The serum levels of VEGF, TGF-β, and IGF-1 were significantly lower in the Fx +WTS42 group, and PTH in the Fx +WTS28 group was higher than that in the other groups.Significance: The findings showed the disturbance and delay in the femoral fracture union in rats exposed to hookah smoke. This is partly due to the reduction of molecular stimuli of bone synthesis and the attenuation of quantitative angiogenesis.

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Influence of vitamin D in bone healing

Cited by 5 publications

References 19 publications

Diode laser assisted horizontal bone defect regeneration in the treatment of peri‐implantitis

Diode laser assisted horizontal bone defect regeneration in the treatment of peri‐implantitis

The Relationship Between Time Until Full Weight Bearing After Hip Fractures and Vitamin D Levels in Patients Aged 50 Years and Above

The Effect of Waterpipe Tobacco Smoking on Bone Healing Following Femoral Fractures in Male Rats

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