Influence of Vitamin C on Development of Skin Sensitivity to Neoarsphenamine in the Guinea Pig

Sensitization, Immunological Tolerance and Desensitization of Guinea Pigs to Neoarsphenamine II.

“…Already Sulzberger and M ayer (33) had reported, that guinea pigs fed in winter with a presumably vitamin-C deficient diet were more easily and regularly sensitized, such findings being confirmed later by other authors (4,34,35). These reports, as well as the general interest in the role of vitamins, inspired numerous authors in the 1930's to investigate the influence of various vitamins in the immune processes (13,18,22,28,31,32), but conflicting results were reported.…”

Experimental arsphenamine dermatitis: The influence of vitamin C in the production of arsphenamine sensitiveness

“…As will be seen in Table I Conclusions.- (1) A low vitamin C diet increased the intensity of the initial reactions and retarded their involution. (2) There seemed to be very little inhibiting effect of large doses of vitamin C for one week on the reactions to the second injection, except for some delay in the appearance of the lesions.…”